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Guanidines pp 213–225Cite as

Taurine and the Actions of Guanidinoethane Sulfonate

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Abstract

It has been recognized that major handicaps to the elucidation of the functional significance of taurine in mammals were the absence of simple methods for depleting tissues of taurine, and the absence of a pharmacological antagonist to taurine1,2. These handicaps have been lessened since the introduction of the structural analogue of taurine, guanidinoethane sulfonate (GES), as a tool for modifying taurine levels in certain species3.

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References

  1. R. J. Huxtable, Does taurine have a function ?, Trends in Pharmacological Sciences 1: 6–7 (1979).

    Google Scholar 

  2. R. J. Huxtable, Does taurine have a function ? Introduction, Fed. Proceedings 39:2678–2679 (1980).

    Google Scholar 

  3. R. J. Huxtable, H. F. Laird and S. E. Lippincott, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Pharm. Exp. Therap. 211:465–471 (1979).

    Google Scholar 

  4. R. P. Shields and C. K. Whitehair, Muscle creatine: in vivo depletion by feeding ß-guanidinopropionic acid, Can. J. Biochem. 51:1046–1049 (1973).

    Google Scholar 

  5. C. D. Fitch, M. Jellinek and E. J. Mueller, Experimental depletion of creatine and phosphocreatine from skeletal muscle, J. Biol. Chem. 249:1060–1063 (1974).

    Google Scholar 

  6. R. Huxtable and S. E. Lippincott, Comparative metabolism and taurine depleting effects of guanidinoethane sulfonate in cats, mice and guinea pigs, Arch. Biochem. Biophys. 210:698–709 (1981).

    Google Scholar 

  7. J. B. Lombardini, Combined effects of guanidinoethane-sulfonate, a depletor of tissue taurine levels, and isoproterenol or methaxamine on rat tissues, Biochem. Pharmacol. 30:1698–1701 (1981).

    Google Scholar 

  8. N. Lake, Depletion of retinal taurine by treatment with guanidinoethyl sulfonate, Life sciences 29: 445–448 (1981).

    CAS  Google Scholar 

  9. N. Lake, Depletion of taurine in the adult rat retina, Neurochem. Res. 7:1385–1390 (1982).

    Google Scholar 

  10. M. C. Welty, J. D. Welty and M. J. McBroom, Effect of isoproterenol and taurine on heart calcium in normal and cardiomyopathic hamsters, J. Mol. Cell. Cardiol. 14:353–358 (1982).

    Google Scholar 

  11. S. Y, Schmidt, E. L. Berson and K. C. Hayes, Retinal degeneration in cats fed casein 1. Taurine deficiency, Invest. Ophthalmol. 15:47–52 (1976).

    Google Scholar 

  12. R. J. Huxtable, Guanidinoethane sulfonate and the disposition of dietary taurine in the rat, J. Nutrition 12:2293–2300 (1982).

    Google Scholar 

  13. A. Mori, Y. Katayama, I. Yokoi and M. Matsumoto, Inhibition of taurocyamine (guanidinotaurine)-induced seizures by taurine, in:“The Effects of Taurine on Excitable Tissue,”S. W. Schaffer, S. I. Baskin and J. J. Kocsis, eds., Spectrum Press, 41–48 (1981).

    Google Scholar 

  14. J. A. Sturman, Taurine in nutrition research, in:“Sulfur Amino Acids: Biochemical and Clinical Aspects,” K. Kuriyama, R. J. Huxtable and H. Iwata, eds., A. R. Liss, New York, 281–295 (1981).

    Google Scholar 

  15. D. K. Rassin, J. A. Sturman and G. E. Gaull, Taurine and other free amino acids in milk of man and other mammals, Early Human Develop. 2: 1–13 (1978).

    CAS  Google Scholar 

  16. H. S. Geggel, M. E. Ament, J. R. Hackenlively and J. D. Kopple, Evidence that taurine is an essential amino acid in children receiving total parenteral nutrition,Clin. Res. 30:486a (1982).

    Google Scholar 

  17. R. J. Huxtable, Sources and turnover rates of taurine in nursing and weaned rat pups, J. Nutrition 111:1275–1286 (1981).

    Google Scholar 

  18. R. J. Huxtable and S. E. Lippincott, Relative contribution of the mother, the nurse and endogenous synthesis to the taurine content of newborn and suckling rat, Nutrition and Metabolism 27: 107–116 (1983).

    CAS  Google Scholar 

  19. H. Pasantes-Morales, 0. Quesada, A. Carabez and R. J. Huxtable, Effects of the taurine transport antagonists, guanidinoethane sulfonate and -alanine, on the morphology of rat retina, J. Neurosci. Res. 9:135–143 (1983).

    Google Scholar 

  20. K. C. Hayes, A. R. Rabin and E. L. Berson, An ultrastructural study of nutritionally induced and reversed retinal degeneration in cats, Am. J. Pathol. 78:505–524 (1975a).

    Google Scholar 

  21. K. C. Hayes, R. E. Carey and S. Y. Schmidt, Retinal degeneration associated with taurine dificiency in the cat, Science 188: 949–951 (1975b).

    CAS  Google Scholar 

  22. A. K. Thakur and L. W. Fezio, A computer program for estimating LD50 and its confidence limits using modified Behrens -Reed-Muench cumuland method, Drug and Chemical Toxicology 4: 297–305 (1981).

    Google Scholar 

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© 1985 Springer Science+Business Media New York

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Huxtable, R.J., Bonhaus, D., Nakagawa, K., Laird, H.E., Pasantes-Morales, H. (1985). Taurine and the Actions of Guanidinoethane Sulfonate. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_22

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  • DOI: https://doi.org/10.1007/978-1-4757-0752-6_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0754-0

  • Online ISBN: 978-1-4757-0752-6

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