Skip to main content
SpringerLink
Log in

Hydrophilic/Hydrophobic Control of Steroid Release from a Cortisol — Polyglutamic Acid Sustained Release System

  • Chapter
Controlled Release of Pesticides and Pharmaceuticals

Abstract

Biodegradable polymer formulations which allow delivery of biologically active agents to a target organ or organism at controlled rates over a prolonged period of time have been developed and studied.1,2 These biodegradable controlled-release systems offer the distinct advantage that no residual polymer remains following release of the drug and degradation of the polymer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. K.R. Sidman, W.D. Steber, and A.W. Burg, in “Proceedings Drug Delivery Systems,” H.L. Gabelnick, ed., Bethesda (1976).

    Google Scholar 

  2. C. Pitt, D. Christensen, R. Jeffcoat, G.L. Kimmel, A. Schindler, M.E. Wall, and R.A. Zweidinger, ibid., pp. 141–192.

    Google Scholar 

  3. S. Mitra, M. Van Dress, J.M. Anderson, unpublished results.

    Google Scholar 

  4. A.N. Neogi and G.G. Allan, in “Controlled Release of Biologically Active Agents,” A.C. Tranquary and R.E. Lacey, eds., Plenum Press, New York (1974). pp. 195–224.

    Book  Google Scholar 

  5. G.G. Allan, C.S. Chopra, A.N. Neogi, and R.M. Wilkins, Nature 234: 349 (1971).

    Article  PubMed  CAS  Google Scholar 

  6. H. Morawetz, Israel J. Chem. 17: 287 (1978).

    Google Scholar 

  7. G. Smets, Angew. Chem. 74: 337 (1962).

    Article  CAS  Google Scholar 

  8. F.W. Harris, J.W. Thompson, and S. Amdur, in: “Proceedings of 6th International Symposium on Controlled Release of Bioactive Materials,” R.W. Baker, ed, New Orleans (1979). pp. III22.

    Google Scholar 

  9. I.H. Shaw, C.G. Knight, and J.T. Dingle, Biochem. J. 158: 473 (1976).

    CAS  Google Scholar 

  10. J.M. Anderson, D.F. Gibbons, R.L. Martin, A. Hiltner, and R. Woods, J. Biomed. Mater. Res. Symposium 5: 197 (1974).

    Article  Google Scholar 

  11. A.H. Janoski, F.C. Shulman, and G.E. Wright, Steroids 23: 49 (1974).

    Article  PubMed  CAS  Google Scholar 

  12. M. Idelson and E.R. Blout, J. Amer. Chem. Soc. 80: 4631 (1958).

    Article  CAS  Google Scholar 

  13. G.I. Poos and L.H. Sarret, U.S. Patent, 3,074, 979 (1963).

    Google Scholar 

  14. G. Smets and W. Van Humbeck, J. Polymer Sci., A, 1: 1227 (1963).

    CAS  Google Scholar 

  15. R.W. Baker and H.K. Lonsdale, in: “Controlled Release of Biologically Active Agents,” A.C. Tranquary and R.E. Lacey, eds., Plenum Press, New York (1974). pp. 195–224.

    Google Scholar 

  16. T. Higuchi, J. Pharm. Sci., 50: 874 (1961).

    Article  PubMed  CAS  Google Scholar 

  17. H.B. Hopfenberg, in: “Controlled Release Polymeric Formulations,” D.R. Paul and F.W. Harris, eds., ACS Symposium Series 33:26 (1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    N. Tani, M. Van Dress & J. M. Anderson

Authors
  1. N. Tani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Van Dress
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Southern Research Institute, Birmingham, Alabama, USA

    Danny H. Lewis

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer Science+Business Media New York

About this chapter

Cite this chapter

Tani, N., Van Dress, M., Anderson, J.M. (1981). Hydrophilic/Hydrophobic Control of Steroid Release from a Cortisol — Polyglutamic Acid Sustained Release System. In: Lewis, D.H. (eds) Controlled Release of Pesticides and Pharmaceuticals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0737-3_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0737-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0739-7

  • Online ISBN: 978-1-4757-0737-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation