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Controlled Release of Pesticides and Pharmaceuticals pp 49–65Cite as

Anthracycline-DNA Complexes as Slow-Release Preparations in the Treatment of Acute Leukemia

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Abstract

The anthracycline antibiotics daunorubicin (DNR) and doxorubicin (DOX, adriamycin) play a prominent role in the treatment of acute leukemia.1,2 The most successful programs for treatment of acute non-lymphoblastic leukemia (ANLL) in adults now cause remission in about 70–80% of previously untreated patients. But most patients relapse despite maintenance therapy given at certain intervals. The response rate is then much lower and most of these patients are resistant to the drugs which initially caused remission.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Karolinska Institute, S-104 01, Stockholm, Sweden

    Curt Peterson

  2. Section of Oncology and Hematology Department of Medicine, Huddinge Hospital, S-141 86, Huddinge, Sweden

    Christer Paul & Gösta Gahrton

Authors
  1. Curt Peterson
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  2. Christer Paul
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  3. Gösta Gahrton
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Editor information

Editors and Affiliations

  1. Southern Research Institute, Birmingham, Alabama, USA

    Danny H. Lewis

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© 1981 Springer Science+Business Media New York

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Peterson, C., Paul, C., Gahrton, G. (1981). Anthracycline-DNA Complexes as Slow-Release Preparations in the Treatment of Acute Leukemia. In: Lewis, D.H. (eds) Controlled Release of Pesticides and Pharmaceuticals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0737-3_5

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  • DOI: https://doi.org/10.1007/978-1-4757-0737-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0739-7

  • Online ISBN: 978-1-4757-0737-3

  • eBook Packages: Springer Book Archive

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