Abstract
The diffusional release of a dispersed or dissolved drug from a polymeric matrix generally involves the presence of a moving diffusional front separating the undissolved core and the partially extracted region. In the case of an erodible or swellable polymer matrix, the release kinetics is further complicated by the presence of a second moving boundary, namely the eroding or swelling polymer front. The mathematical descriptions of such mass transfer problems involving moving boundaries are known as moving boundary problems, free boundary problems, or simply Stefan problems. Except for some special cases, the presence of a moving boundary introduces a nonlinearity so that only a few exact solutions are known.1–3 In addition to numerical schemes, various approximate analytical techniques have been applied to moving boundary problems developed in other areas such as freezing and melting with varying degree of success.2,3 However, only very simple pseudosteady state approximations have been used to analyze the release of a dispersed drug from a polymeric matrix.4,5
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References
J. Crank, in: “Mathematics of Diffusion,” 2nd ed., Clarendon Press, Oxford (1975).
J.R. Ockendon and W.R. Hodgkins, in: “Moving Boundary Problems in Heat Flow and Diffusion,” Clarendon Press, Oxford (1975).
D.G. Wilson, A.D. Solomon, and P.T. Boggs, in: “Moving Boundary Problems,” Academic Press, New York (1978).
R.W. Baker and H.K. Lonsdale, in: “Controlled Release of Biologically Active Agents,” Vol. 47 of Advances in Experimental Medicine and Biology, A.C. Tanquary and R.E. Lacey, eds., Plenum Press, New York (1974). pp. 15–72.
T. Higuchi, J. Pharm. Sci. 50: 874 (1961).
D.R. Paul and S.K. McSpadden, J. Membrane Sci. 1: 33 (1976).
H.B. Hopfenberg, in: “Controlled Release Polymeric Formulations,” Vol. 33 of ACS Symposium Series, ACS, Washington (1976). pp. 26–32.
R.W. Baker and H.K. Lonsdale, Div of Organic Coatings and Plastics Preprints, ACS 3 (1): 229 (1976).
N.A. Peppas, R. Gurny, E. Doelker, and P. Buri, J. Membrane Sci. 7: 241 (1980).
T.R. Goodman, Trans ASME 80: 335 (1958).
V.N. Volkov and V.K. Li-Orlov, Heat Transfer Sov. Res. 2: 41 (1970).
T.R. Goodman, Adv. Heat Transfer 1: 51 (1964).
P.I. Lee, in: “Controlled Release of Bioactive Materials,” R.W. Baker, ed., Academic Press, New York (1980). pp. 135153.
P.I. Lee, J. Membrane Sci. 7: 255 (1980).
J. Heller and R.W. Baker, in: “Controlled Release of Bioactive Materials,” R.W. Baker, ed., Academic Press, New York (1980). pp. 1–17.
A. Peterlin, J. Polym. Sci., Polym. Phys. Ed. 17:1741 (1979).
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© 1981 Springer Science+Business Media New York
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Lee, P.I. (1981). Controlled Drug Release from Polymeric Matrices Involving Moving Boundaries. In: Lewis, D.H. (eds) Controlled Release of Pesticides and Pharmaceuticals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0737-3_4
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DOI: https://doi.org/10.1007/978-1-4757-0737-3_4
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