Abstract
One of the major drawbacks of all practical approaches thus far developed for fabricating diffusion-controlled matrices for drug delivery is that the release rates decrease with time. From a pharmaceutical standpoint, it would be desirable for, many such systems to display zero-order release kinetics. Furthermore, in some circumstances (e.g., insulin delivery in diabetics) it would be useful to be able to achieve increased dosages on demand. In the present study, we present experimental approaches for achieving both of these objectives.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
W. Rhine, V. Sukhatme, D. Hsieh, and R. Langer, in: “Controlled Release of Bioactive Materials,” R.W. Baker, ed., Academic Press, New York (1980). p. 177.
B Brooke, and R. Washkuhn, J. Pharm. Sci 66: 159 (1977).
R.A. Lipper, and W.I. Higuchi, J. Pharm. Sci. 66: 163 (1977).
R. Langer, Chem. Eng. Commun. 6: 1 (1980).
H. Hopfenberg, in: “Controlled Release Polymeric Formulations,” D.R. Paul and F.W. Harris, eds., American Chemical Society, Washington (1976). p. 26.
W.D. Rhine, D.S.T. Hsieh, and R. Langer, J. Pharm. Sci. 69: 265 (1980).
R. Langer, and J. Folkman, Nature 263: 797 (1976).
D. Hsieh, R. Langer, and J. Folkman, Proc. Natl. Acad. Sci. in press.
R. Langer, H. Brem, and D. Tapper, J. Biomed. Mat. Res., in press.
R. Langer, W. Rhine, D. Hsieh, and R. Bawa, in: “Controlled Release of Bioactive Materials,” R.W. Baker, ed., Academic Press, New York (1980). p. 83.
J. Heller, and P. Trescony, J. Pharm. Sci. 68: 919 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hsieh, S.T., Langer, R. (1981). Experimental Approaches for Achieving Both Zero-Order and Modulated Controlled Release from Polymer Matrix Systems. In: Lewis, D.H. (eds) Controlled Release of Pesticides and Pharmaceuticals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0737-3_2
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0737-3_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0739-7
Online ISBN: 978-1-4757-0737-3
eBook Packages: Springer Book Archive