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Inactive Renin — A Renin Proenzyme?

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Acid Proteases: Structure, Function, and Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 95))

Abstract

Renin cleaves an α-globulin substrate to produce the decapeptide angiotensin I. This is converted by other enzymes to the vasoconstrictor octapeptide angiotensin II. Renin is produced mainly by the kidney although extra-renal sources of the enzyme have been reported (1,2). Boyd (3) showed that in pig kidneys there is a slow-acting renin with a molecular weight (m.w.) of 60,000 as against 40,000 for active pig renin. After acidification, the slow-acting renin becomes more active and its m.w. is 40,000. In rabbit kidney extracts (4) there is an inactive renin of m.w. around 55,000, which, after exposure to pH 3.0, becomes active and its m.w. falls to 37,000, similar to that of active renin. Morris and Johnston (5) have reported an acid-activatable inactive renin of m.w. 44,000 in rat kidneys. In human kidney extracts an acid-activatable renin has been detected (6) and Day and Leutscher (7) and Day, Leutscher, and Gonzales (8) showed that inactive renin of m.w. 60,000 is present in some renal tumors and extracts of kidneys from diabetic patients. Eggena, Barrett, Silpipat and Sambhi (9) have shown that a high m.w. renin is present in human kidney. Slater and Haber (10) isolated a renin of m.w. 63,000 from normal human kidney. An acid-activatable renin is also present in human amniotic fluid (11) and human plasma (12,13,14).

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References

  1. Carretero, O. A., and Houle, J. A. (1970) Amer. J. Physiol. 218, 689–692

    Article  CAS  Google Scholar 

  2. Ganten, D., Minnich, J. L., Granger, P., Hayduk, K., Brecht, H. M., Barbeau, A., Boucher, R., and Genest, J. (1971) Science 173, 64–65

    Article  CAS  Google Scholar 

  3. Boyd, G. W. (1974) Circ. Res. 35, 426–438

    Article  CAS  Google Scholar 

  4. Leckie, B. J., and McConnell, A. (1975) Circ. Res. 36, 513–519

    Article  CAS  Google Scholar 

  5. Morris, B. J., and Johnston, C. I. (1976) Endocrinology 98, 1466–1474

    Article  CAS  Google Scholar 

  6. Leckie, B., and McConnell, A. (1975) in 10th Acta Endocrinologica Congress, pp. 280, Amsterdam, Periodica, Copenhagen

    Google Scholar 

  7. Day, R. P., and Luetscher, J. A. (1974) J. Clin. Endocrinol. Metab. 38, 923–926

    Article  CAS  Google Scholar 

  8. Day, R. P., Luetscher, J. A., and Gonzales, C. M. (1975) J. Clin. Endocrinol. Metab. 40, 1078–1093

    Article  CAS  Google Scholar 

  9. Eggena, P., Barrett, J. D., Silpipat, C., and Sambhi, M. P. (1976) Fed. Proc. 35, 705

    Google Scholar 

  10. Slater, E. E., and Haber, E. (1976) Circulation 53 and 54 ( Suppl. II ), 143

    Google Scholar 

  11. Lumbers, E. R. (1971) Enzymologia 40, 329–336

    CAS  PubMed  Google Scholar 

  12. Derkx, F. H. M., Gool, J. M. G., Wenting, G. J., Verhoeven, R. P., Maninveld, A. J., Schalekamp, M. A. D. H. (1976) Lancet II, 496–498

    Article  Google Scholar 

  13. Leckie, B. J., McConnell, A., Grant, J., Morton, J. J., Tree, M., and Brown, J. J. (1977) Circ. Res. 40 (In Press)

    Google Scholar 

  14. Leckie, B., Brown, J. J., Lever, A. F., McConnell, A., Morton, J. J., Robertson, J. I. S., Tree, M. (1976) Lancet II, 748

    Article  Google Scholar 

  15. Yalow, R. S. (1974) Recent Progress in Hormone Research 30, 597–633

    CAS  PubMed  Google Scholar 

  16. Skinner, S. L., Lumbers, E. R., and Symonds, E. M. (1972) Clin. Sci. 42, 479–488

    Article  CAS  Google Scholar 

  17. Tree, M. J. (1973) J. Endocrinol. 56, 159A - 171

    Article  Google Scholar 

  18. Bangham, D. R., Robertson, I., Robertson, J. I. S., Robinson, C. J., and Tree, M. (1975) Clin. Sci. and Mol. Med. 48, 135s - 159s

    Google Scholar 

  19. Skinner, S. L., Cran, E. J., Gibson, R., Taylor, R., Walters, V. A. W., and Catt, K. J. (1975) Amer. J. Obstet. Gynecol. 121, 626–630

    Article  CAS  Google Scholar 

  20. Cooper, R. M., Osmond, D. H., Scaiff, K. D., and Ross, L. J. (1974) Fed. Proc. 33, 584

    Google Scholar 

  21. Murray, G. E., and Osmond, D. H. (1975) Fed. Proc. 34, 367

    Google Scholar 

  22. Morris, B. J., and Lumbers, E. R. (1972) Biochim. Biophys. Acta 289, 385–391

    Article  CAS  Google Scholar 

  23. Schwert, G. W., and Takenaka, Y. (1953) Biochim. Biophys. Acta 16, 570–575

    Article  Google Scholar 

  24. Regoli, D. (1970) Can. J. Physiol. Pharmacol. 48, 350–358

    Article  Google Scholar 

  25. Andrews, P. (1964) Biochem. J. 91, 222–233

    Article  CAS  Google Scholar 

  26. Kunitz, M., and Northrop, J. H. (1936) J. Gen. Physiol. 19, 991–1007

    Article  CAS  Google Scholar 

  27. Saklatvala, J., Wood, G. C., and White, D. D. (1976) Biochem. J. 157, 339–351

    Article  CAS  Google Scholar 

  28. Van Vanukis, H., and Herriott, R. M. (1956) Biochim. Biophys. Acta 22, 537–543

    Article  Google Scholar 

  29. Murakami, K., Matoba, T., and Inagami, T. (1976) Fed. Proc. 35, 1355

    Google Scholar 

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Author information

Authors and Affiliations

  1. M. R. C. Blood Pressure Unit, Western Infirmary, Glasgow, G11 6NT, Scotland

    B. J. Leckie, A. McConnell & J. Jordan

Authors
  1. B. J. Leckie
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  2. A. McConnell
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  3. J. Jordan
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Editors and Affiliations

  1. Oklahoma Medical Research Foundation, USA

    Jordan Tang

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Leckie, B.J., McConnell, A., Jordan, J. (1977). Inactive Renin — A Renin Proenzyme?. In: Tang, J. (eds) Acid Proteases: Structure, Function, and Biology. Advances in Experimental Medicine and Biology, vol 95. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0719-9_15

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  • DOI: https://doi.org/10.1007/978-1-4757-0719-9_15

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-0721-2

  • Online ISBN: 978-1-4757-0719-9

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