Abstract
For nearly 2 decades our laboratory has carried on microelectrode studies of the auditory nervous system. A primary objective of these studies is to determine how the properties of an acoustical stimulus are represented or coded in the temporal patterns of all-or-none spike discharges that may be recorded from single neural units (cell bodies or fibers). For many years, following the pioneering observations of Galambos and Davis (3), the only available methods for study of unit discharge patterns involved either laborious manual measurement of oscilloscope tracings or rough estimation of the threshold of unit discharge by listening to the amplified activity. Although qualitative techniques were developed to deal with the massive amounts of data that result from experiments of this kind, it was not until Gerstein and Kiang (4) and their colleagues at MIT introduced the digital computer that it became possible to perform precise statistical analyses of unit discharge patterns as they occur in real time.
This research was aided by NIH grants NS 06225 and RR 00249.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brugge, J. F., D. J. Anderson, J. E. Hind and J. E. Rose. Time structure of discharges in single auditory nerve fibers of the squirrel monkey in response to complex periodic sounds. J. Neurophyswl. 32: 386–401, 1969.
Clark, W. A., and C. E. Molnar. A description of the LINC. In: Computers in biomedical research, edited by R. W. Stacy and B. Waxman, New York: Academic, 1965.
Galambos, R., and H. Davis. The response of single auditory-nerve fibers to acoustic stimulation. J. Neurophysiol. 6: 39–57, 1943.
Gerstein, G. L., and N. Y.-S. Kiang. An approach to the quantitative analysis of electrophysiological data from single neurons. Biophys. J. 1: 15–28, 1960.
Hind, J. E., and H. Ludwig. Adaptation of the CDC 160 computer to measurement of the temporal discharge characteristics of single neural units. Proc. 16th Ann. Conf. Eng. Med. Bwl. 5: 64–65, 1963.
Rhode, W. S. Observations of the vibration of the basilar membrane in squirrel monkeys using the Mössbauer technique. J. Acoust. Soc. Am. 49: 1218–1231, 1971.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hind, J.E., Rhode, W.S. (1974). Computer-based auditory neurophysiology laboratory. In: Siler, W., Lindberg, D.A.B. (eds) Computers in Life Science Research. FASEB Monographs, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0546-1_14
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0546-1_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0548-5
Online ISBN: 978-1-4757-0546-1
eBook Packages: Springer Book Archive