Abstract
In an effort to develop additional treatments and improved methods for early detection of ovarian cancers a number of monoclonal antibodies (MAbs) have been generated against cell surface antigens of epithelial ovarian cancer (EOC). Therapies using these reagents to target ovarian cancers have so far been disappointing. Identifying the antigens recognized by the antibody may be important for improving the targeting of antibody based therapy. For example, detailed molecular analysis of the polymorphic epithelial mucin gene, MUCl, has shown that differential glycosylation of a tandem repeat unit is responsible for the appearance of novel epitopes in breast, ovarian and other adenocarcinomas [1]. This information has opened up new possibilities for immunotherapy with mucins since these structures are highly immunogenic and are relatively tumour specific. The encouraging results of such studies prompted us to undertake the cloning of the genes for other MAb defined tumour antigens based on an expression cloning technique [2]. In this chapter we briefly summarize the important characteristics of the genes cloned so far and discuss their possible function in ovarian cancer.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Taylor-Papadimitriou, J., Allen, D., Granowska, M. et al, (1992) Molecular structure and clinical applications of a cancer-associated mucin. InOvarian Cancer, 2, Biology, Diagnosis and Management, (eds F. Sharp, W. P. Mason and W. Creasman), Chapman Hall, London, pp. 39–50.
Seed, B. (1987) An LFA-3 cDNA encodes a phospholipid membrane protein homologous to its receptor CD2. Nature, 329,840–2.
Campbell, I.G., Foulkes, W.D., Jones, T.A. et al, (1992) Cloning of genes encoding ovarian carcinoma-specific antigens. In Ovarian Cancer, 2, Biology, Diagnosis and Management, (eds F. Sharp, W.P. Mason and W. Creasman), Chapman & Hall, London, pp. 73–86.
Campbell, I.G., Jones, T.A., Foulkes, W.D. et al, (1991) Folate binding protein is a marker for ovarian cancer. Cancer Res., 51,5329–38.
Henderson, G.B. (1990) Folate binding proteins. Ann. Rev. Nutr., 10,319–35.
Garin-Chesa, P., Campbell, L, Saigo, P. F. et al., (1993) Trophoblast and ovarian cancer antigen LK26.Am. J. Pathol, 142,557–67.
Poels, L.G., Peters, D., van Megen, Y. et al, (1986) Monoclonal antibody against human ovarian tumor associated antigens. J. Natl Cancer Inst., 76, 781–91.
Buist, M.R., Kenemans, P., Vermerken, J.B. et al, (1992) Radioimmunotargeting in ovarian carcinoma patients with indium-Ill labelled monoclonal antibody OV-TL3 F(ab02: pharmacokinetics, tissue distribution, tumour imaging. Int. J. Gynecol Cancer, 2,23–34.
Campbell, LG., Freemont, P.S., Foulkes, W.D. et al, (1992) An ovarian tumour marker with homology to vaccinia virus contains an IgVlike region and multiple transmembrane domains. Cancer Res., 52,5416–20.
Williams, A.F. and Barclay, A.N. (1988) The immunoglobulin superfamily — domains for cell surface recognition. Ann. Rev. Immunol, 6, 318–405.
Smith, G.L., Chan, Y.S. and Howard, ST. (1991) Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted 18. terminal repeat. J. Gen. Virol, 72,1349–76.
Massuger, L.F.A., Kenemans, P., Claessens, R.A.M.J. et al, (1991) Detection and localization of ovarian cancer with radiolabeled monoclonal antibodies. Eur. J., Obstet. Gynecol Reprod. Biol, 41,47–63.
Boerman, O.C., Makkink, W.K., Thomas, C.M.G. et al, (1990) Monoclonal antibodies that discriminate between human ovarian carcinomas and benign ovarian tumours. Eur. J. Cancer, 26,117–27.
Simmonds, D., Makgoba, M.W. and Seed, B. (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural-cell adhesion molecule NCAM. Nature, 331,624–7.
Johnson, J.P. (1991) Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and 22. progression to metastatic disease. Cancer Metastasis Rev., 10,11–12.
Holzmann, B., Brocker, E.B., Lehmann, J.M. et al, (1987) Tumor progression in human malignant melanoma: five stages defined by their 23. antigenic phenotypes. Int. J. Cancer, 39,466–71.
Favrot, M.C., Combaret, V., Goillot, E. et al, (1991) Expression of leucocyte adhesion molecules on 66 clinical neuroblastoma specimens. Int. J. Cancer, 48,502–10.
Tsujisaki, M., Imai, K., Hirata, H. et al, (1991) Detection of circulating intercellular adhesion molecule-1 ntigen in malignant diseases. Clin. Exp. Immunol, 85,3–8.
Rettig, W.J., Chesa, P.C., Beresford, H.R. et al, (1986) Differential expression of cell surface antigens and glial fibrillary acidic protein in human astrocytoma subsets.Cancer Res., 46, 6406–12.
Rettig, W.J., Garin-Chesa, P., Beresford, H.R. et al, (1988) Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells. Immunology, 85,3110–14.
Foulkes, W.D., Campbell, I.G. Stamp, G.W.H. et al, (1993) Loss of heterozygosity and amplification on chromosome llq in human ovarian cancer. Br. J. Cancer, 67,268–73.
Miotti, S., Canevari, S., Menard, S. et al, (1987) Characterization of human ovarian carcinoma-associated antigens defined by monoclonal antibodies with tumor-restricted specificity. Int. J. Cancer, 39,297–303.
Ragoussis, J., Senger, G., Trowsdale, J. et al, (1992) Genomic organisation of the human folate receptor genes on chromosome 11ql3. Genomics, 14,423–30.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Chapman & Hall
About this chapter
Cite this chapter
Campbell, I.G., Foulkes, W.D., Jones, T.A., Poels, L.G., Trowsdale, J. (1995). Cloning and molecular characterization of monoclonal antibody-defined ovarian tumour antigens. In: Sharp, F., Mason, P., Blackett, T., Berek, J. (eds) Ovarian Cancer 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0136-4_6
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0136-4_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0138-8
Online ISBN: 978-1-4757-0136-4
eBook Packages: Springer Book Archive