Abstract
It is well known that leukocytes play key roles in mechanisms of body defense against both endotoxins and exotoxins. The factors involved in triggering such defense mechanisms involve an activation of cellular membrane processes, among which is the release (from phospholipids) of AA and its subsequent metabolism into various icosanoids. The liberation of such icosanoids (e.g. LTs, PGs, HPETEs), in addition to the formation of superoxide and other oxygen free radicals and the liberation of histamine and certain degradative enzymes (e.g., elastase, collagenase), play key roles not only in the destruction of suitable ingestible particles but also in the recruitment (chemotaxic effect) of other cells for this process. All of these events depend upon the generation and transmission of a membrane signal which involves mainly membrane metabolism and ion transport1.
Keywords
- Human Leukocyte
- Leukocyte Activation
- Arachidonic Acid Cascade
- Membrane Signal
- Transient Hyperpolarization
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
J.E.Smolen, H.M. Korchak and G. Weissmann in:Cell Biology of the Secretory Process (M.Cantin, ed), Karger, Basel, pp 517–545 (1984)
O. Oelz, H.R. Knapp, H.R. Roberts, L.J.Oelz, B.J.Sweetman, J.A.Oates and P.W. Reed. Calcium dependent stimulation of thromboxane and prostaglandin biosynthesis by ionophores. In: Advances in Prostaglandin and Thrombanxe Research, Vol.3 (C.Galli, ed.) Raven Press, New York, pp. 148–158 (1978).
R. Dusing, R. Scherhag, R. Tippelman, U. Udde, K. Glanzer and H.J. Kramer. Arachidonic acid metabolism in isolated rat aorta. Dependence of prostacyclin biosynthesis on extracellular potassium concentration. J. Biol. Chem. 257: 1993–1996 (1982).
J.R. Gill, Bartter’s syndrome. Annu. Rev. Med. 31: 405–419 (1980).
F. Skrabal, J. Aubock and H. Hortnagl, Low Sodium/High potassium diet for prevention of hypertension: probable mechansims of action. Lancet, 2 (8252): 895–900 (1981).
W. Willbrandt. A relation between the permeability of the red cell membrane and its metabolism. Trans. Faraday Soc. 33: 956–959 (1937).
G. Gardos. Biochem. Biophys. Acta, 30, 653–654 (1958).
F.M.Kregenow and J.F.Hoffman, Some Kinetic and metabolic characteristics of calcium-induced potassium transport in human red cells, J. Gen. Physiol. 60: 406–429 (1972).
V.L. Lew and H.G.Ferreìra in: Membrane Transport in Red Cells ( J.C. Ellory and V.L. Lew, eds), Academic Press, New York, pp 93–100 (1977).
V.L. Lew and H.G. Ferreira: Curr. Top. Membr.Transp. 20:217–277 (1978) .
J.F. Hoffman, D.R. Yingst, J.M. Goldinger, R.M. Blum and P.A.Knauf in: Membrane Transport in Erythrocytes (U.V. Lassen, H.H. Ussing and J.0. Wieth, eds.) Munksgaard, Copenhagen, pp. 178–192 (1980).
W. Schwartz and H. Passow, Cat+-activated K+ channels in erythrocytes and excitable cells. Ann. Rev. Physiol. 45: 359–374 (1983).
G. Gardos, The role of Ca in the potassium permeability of human erythrocytes. Acta Physiol Acad.Sci.Hung. 15: 121–125. (1959).
G. Gardos, Effect of ethylenediaminetetraacetate on the permeability of human erythrocytes. Bioch. Biophys. Acta Physiol. Acad. Sci Hung. 14: 1–5 (1958).
O.H. Petersen and Y. Maruyamä, Calcium-activated potassium channels and their role in secretion. Nature (London) 307 : 693–6 (1984) .
I. Atwater, C.M. Dawson, B.Ribalet and E.Rojas, Potassium permeability activated by intracellular calcium ion concentration in the pancreatic B - cell. J. Physiol. 288 :575–88 (1979) .
W.J. Malaisse and A. Herchuelz, Nutritional regulation of K+ conductance: an unsettled aspect of pancreatic B cell physiology. In: Biochemical actions of hormones Vol IX G.Academic Press Inc. N.Y. pub., pp. 69–92 (1982).
J.C. Henquin4 Opposite effects of intracellular Ca2+ and glucose on K permeability of pancreatic islet cells. Nature (London) 280: 66–68 (1979).
J.A. Young,in: Membrane transport in biology Vol. IV G.Giebisch ed., Springer (Berlin) pub.,pp. 563–692 (1979).
W.W. Douglas and A.M. Poisner, The influence of calcium on the secretory response of the submaxillary gland to aceth!lcholine or to nordrenaline. J. Physiol. (London) 165: 528–541 (1963).
P. Braquet, B.Spinnewyn, B.Lehuu, M.Braquet,E. Chabrier, F. Dray and F.V. DeFeudis, Prost.Leukotri.Med., in press.
P. Borgeat, B. Fruteau de Laclos:, S. Rabinovitch, S. Picard, P. Braquet, J. Hebert and J. Laviolette, J. Allergy Immunol., in press.
G.M. Burgess, M. Claret, D.H. Jenkinson, Effects of quinine and apamin on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells. J. Physiol.(London) 317: 67–90 (1981) .
H.M.Karchak and G. Weissmann, Changes in membrance potential of human granulocytes antecede the metabolic responses to surface stimulation. Proc.Natl. Acad.Sci. USA 75: (8). 3818–22 (1978).
E. Edmonson and Ting-Kai Li, Effects of the ionophore A23187 on erythrocytes: relationship of ATP.2–3 diphosphoglycerate to calcium binding capacity. Biochem. Biophys.Acta. 443: 106113 (1976).
E.K. Gallin, M.L.Wiederhold, P.E. Lipsky and A.S.Rosenthal Spontaneous and induced membrane hyperpolarizations in macrophages. J. Cell Physio1. 86: 653–661 (1975).
E.K. Callin and J.I. Gallin. Interaction of chemotactic factors with human macrophages. J. Cell Biology, 75: 277–89 (1977).
G.M. Oliveira-Castro and G.A. Dos Reis. Electrophysiology of phagocytic membranes. III. Evidence for a calcium-dependent potassium permeability change during slow hyperpolarizations of activated macrophages. Biochem.Biophys.Acta, 640: 500–511, (1981).
H.J. Showel, P.H. Naccache,+R.I.+Sha’afid E.L. Becker. The effects of extra-cellular K+, Na, and Ca on lysosomal enzyme secretion from polymorphonuclear leukocytes. J.Immun. 119: 804–811 (1977).
H.M. Korchak and G. Weissman. Stimulus-response coupling in the human neutrophil. Membrane potential changes and the role of extra-cellular Na +. Biochem.Biophys.Acta, 601: 180–194 (1980).
M. Braquet, A. Chereau, E. Chabrier and P. Braquet. The membrane signal in human leukocyte: Evidence for a calcium-dependent potassium permeability in A23187-induced triggering of arachidonate cascade. Biomed.Biophys.Acta (in press).
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© 1985 Plenum Press, New York
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Braquet, M., d’Onofrio, M., Garay, R., Braquet, P. (1985). Correlation Between K+ Fluxes and the Arachidonic Acid Cascade in Human Leukocyte Stimulated with a 23187 or Melittin. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_29
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DOI: https://doi.org/10.1007/978-1-4684-7841-9_29
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