Abstract
Glucocorticoids are powerful anti-inflammatory agents. Although their chief clinical utility in the treatment of acute and chronic inflammatory processes the knowledge of the mode of action of gluco -corticoids is still fragmentary. However at least some anti-inflammatory effects of glucocorticoids depend on their ability to prevent the formation of arachidonic acid oxidation products, i.e. the prostaglandins and leukotrienes which are important mediators of the inflammatory response. Glucocorticoids although do not inhibit cyclo-oxygenase or lipoxygenase are able to prevent phospholipid deacylation from occurring in intact cells by inhibiting phospholipase A2 thereby causing a shortage of precursor arachidonic acid.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.D. Baxter and G.M. Tomkins, Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells, Proc. natn. Acad. Sci. USA 68: 932 (1971).
R.E. Buller and B.W. O’Malley, The biology and mechanism of steroid hormone receptor interaction with the eukaryotic nucleus, Biochem. Pharmac. 25: 1 (1976).
L. Chan and B.W. O’Malley, Mechanism of action of the sex steroid hormones, New Engl. J. Med. 294: 1372 (1976).
A. Danon and G. Assouline, Inhibition of prostaglandins by corticosteroids requires RNA and protein synthesis. Nature, Lond. 273: 552 (1978).
M. Di Rosa and P. Persico, Mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes, Br. J. Pharmacol. 66: 161 (1979).
R.J. Flower and G.J. Blackwell, Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Nature Lond. 275: 456 (1979).
R. Carnuccio, M. Di Rosa and P. Persico, Hydrocortisone induced inhibitor of prostaglandin biosynthesis in rat leucocytes. Br. J. Pharmacol. 68: 14 (1980).
G.J. Blackwell, R. Carnuccio, M. Di Rosa, R.J. Flower, L. Parente and P. Persico, Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids, Nature Lond. 287: 147 (1980).
F. Hirata, E. Schiffman, K. Venkatasubramanian, D. Salomon and J.A. Axelrod, Phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids Proc. natn. Acad. Sci. USA 77: 2535 (1980).
J.F. Cloix, 0. Colard, B. Rothhut and F. Russo-Marie,Characterization and partial purification of ‘renocortins’ two polypeptides formed in renal cells causing the antiphospholipase-like action of glucocorticoids, Br. J. Pharmacol. 79: 313 (1983).
G.J. Blackwell, R. Carnuccio, M. Di Rosa, R.J. Flower, C.S.J. Langham, L. Parente, P. Persico, N.C. Russel-Smith and D. Stone, Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat, Br. J. Pharmacol. 76: 185 (1982).
F. Hirata, M. Notsu, M. Iwata, L. Parente, M. Di Rosa and J.R. Flower, Identification of several species of phospholipase inhibitory proteins by radioimmunoassay for lipomodulin, Biochem. biophys. Res. Commun. 109: 223 (1982).
P. Coote, M. Di Rosa, J.R. Flower, L. Parente, M. Merrett and J. Wood, Detection and isolation of a steroid-induced anti-phospholipase protein of high molecular weight, Br. J. Pharmacol. 80: 597 (1983).
B. Rothhut, F. Russo-Marie, J. Wood, M. Di Rosa and R.J. Flower, Further characterization of the glucocorticoidinduced anti-phospholipase protein ‘renocortin’, Biochem. biophys. Res. Commun. 117: 878 (1984).
G.J. Blackwell, Specificity and inhibition of glucocorticoidinduced macrocortin secretion from rat peritoneal macrophage, Br. J. Pharmac., 79: 587 (1983).
F. Hirata, The regulation of lipomodulin a phospholipase inhibitory protein in rabbit neutrophils by phosphorylation, J. Biol. Chem., 256: 7730 (1981).
L. Parente, M. Di Rosa, J.R. Flower, P. Ghiara, R. Meli, P. Persico, J.A. Salmon and J.N. Wood, Relationship between the anti-phospholipase and anti-inflammatory effect of glucocorticoid-induced proteins, Eur. J. Pharmac., 99: 233 (1984).
A. Calignano, R. Carnuccio, M. Di Rosa, A. Ialenti and S. oncada, The anti-inflammatory effect of glucocorticoÃdinduced phospholipase inhibitory proteins, Agents and Actions (in press 1984).
M. Di Rosa and D.A. Willoughby, Screens for anti-inflammatory drugs, J. Pharm. Pharmac., 23: 297 (1971).
T. Hattori, T. Hoffman and F. Hirata, Differentiation of a histiocytic lymphoma cell line by lipomodulin a phospholipase inhibitory protein, Biochem. Biophys. Res.Commun., 111: 551 (1983).
T. Uede, F. Hirata, M. Hirashima and K. Ishizaka, Modulaton of the biological activities of IgE binding factors I. Identification of glycosilation-inhibiting factor as a fragment of lipomodulin, J. Immunol., 130: 878 (1983).
M. Koltai, I. Leprà n, G.Y. Nemecz and L. Szekeres, The possible mechanism of protection by dexamethasone against sudden death due to coronary ligation in conscious rats, Br. J. Pharmac., 79: 327 (1983).
F. Hirata, R. Del Carmine, C.A. Nelson, J. Axelrod, E. Schiff-mann, A. Warabi and Others, Presence of autoantibody for phospholipase inhibitory protein lipomodulin in patients with rheumatic diseases, Proc. natn. Acad. Sci. USA, 78: 3190 (1981).
G. Ciabattoni, P. Patrignani, P. Filabozzi, A. Pierucci, B. Simonetti, G.A. Cinotti, E. Pinca, E. Gotti, G. Remuzzi and C. Patrono, Increased renal thromboxane (TX) production in systemic lupus erythematosus (SLE), Clin. Res., 30: 445A (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Di Rosa, M. (1985). The Role of Glucocorticoid-Induced Phospholipase Inhibitory Proteins. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_25
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7841-9_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7843-3
Online ISBN: 978-1-4684-7841-9
eBook Packages: Springer Book Archive