Abstract
The metabolic relationship between the long chain polyunsaturated fatty acid (PUFA), arachidonic acid (AA), and the prostaglandin system was discovered two decades ago. Although information on the eicosanoid family has considerably grown since then, our understanding of the complex relationships between the intake of the fatty acid precursors with the diet and the balance in the formation of various eicosanoids in a given tissue or district is still quite limited.
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References
R.R. Brenner, Nutritional and hormonal factors influencing desaturation of Essential Fatty Acids, in: “Progress in Lipid Research” vol. 20, R.T. Holman Ed. Pergamon Press (1981).
H. Sprecher, Biochemistry of Essential Fatty Acids, in: “Progress in Lipid Research” vol. 20, R.T. Holman Ed., Pergamon Press (1981).
J.J. Bernert and H. Sprecher, Studies to determine the role rates of chain elongation and desaturation play in regulating the unsaturated fatty acid composition of rat liver lipids, Biochim Biophys. Acta, 398: 354 (1975).
C. Galli, E. Agradi, A. Petroni and E. Tremoli, Differential effects of dietary fatty acids on the accumulation of arachidonic acid and its metabolic conversion through the cycloxygenase and the lipoxygenase in platelets and vascular tissue, Lipids 16: 165 (1981).
E. Giani, E. Masi, C. Colombo and C. Galli, Sex differences in platelet thromboxane and arterial prostacyclin production in control n-6 fatty acid supplemented rats, Prostaglandins 28: 573 (1984).
W. Siess, B. Scherer, B. Bohlig, P. Roth, I. Kurzman and P.C. Weber, Platelet membrane fatty acids, platelet aggregation and thromboxane formation during mackerel diet, Lancet i: 441 (1980).
T. Terano, A. Hirai, T. Hamazaki, S. Kobayashi, T. Fujuta, Y. Tamura and A. Kumagai. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red-cell deformability in healthy human subjects, Atheroscl. 46 (3): 321 (1983).
A. Socini, C. Galli, C. Colombo and E. Tremoli, Fish oil administration as a supplement to a Corn Oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat, Prostaglandins 25: 693 (1983).
M.M. Mathias and J. Dupont, The relationship of dietary fats to prostaglandin biosynthesis, Lipids 14: 124 (1979).
S. Fischer and P.C. Weber, Thromboxane A3 (TxA3) is formed in human platelets after dietary eicosapentaenoic acid (C 20:5 omega 3), Biochim. Biophys. Res. Comm. 16 (3): 1091 (1983).
E. Tremoli, A. Petroni, C. Galli, R. Paoletti, P. Puska, R. Dougherty and J. Iacono, North Karelian Study: Changes in dietary fat reduce Thromboxane B2 formation by platelets only in male subjects - Preliminary report, Adv. Prostag. Thromb. Leuko. Res. 12:203 (1983).
A.A. Spector, J.C. Hoak, G.L. Fry, G.M. Denning, L.L. Stall and J.B. Smith, Effect of fatty acid modification on prostacyclin production by cultured human endothelial cells, J. Clin. Invest. 65: 1003 (1980).
A.A. Spector, T.L. Kaduce, P.H. Figard, K.C. Norton, J.C. Hoak and R.L. Czervionke, Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells, J. Lipid Res. 24 (12): 1595 (1983).
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© 1985 Plenum Press, New York
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Galli, C., Giani, E., Masi, I. (1985). Precursor-Product Relationship in Vascular Eicosanoid Formation after Manipulation of Dietary Fatty Acids in Experimental Animals. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_21
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DOI: https://doi.org/10.1007/978-1-4684-7841-9_21
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