Abstract
The exogenous administration of pharmacological doses of mineralocorticoids causes a transient sodium retention which is followed after a few days by a return to a new sodium balance. This latter phenomenon, known as escape from the sodium-retaining effects of mineralocorticoids, is characterized by an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular resistance are observedl. Besides the haemodynamic factors, prostaglandins (PGs) and kallikreinkinin system have been suggested as being responsible, at least partly, for the escape phenomenon.
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© 1985 Plenum Press, New York
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Minuz, P. et al. (1985). The Effect of 9α-Fluorohydrocortisone on the Urinary Excretion of 6-KETO-PGF1α in Man. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_17
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DOI: https://doi.org/10.1007/978-1-4684-7841-9_17
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