Abstract
The wall of the general capillary (tissues other than brain) is freely permeable to all small molecules but the brain capillary wall, the blood-brain barrier (BBB), is impermeable to many small molecules but permeable to certain others. The fundamental difference between these quite different capillary permeability characteristics is diagrammed in Fig. 1. In general capillaries, blood plasma solutes exchange with the more stationary pericapillary extracellular fluid (ECF) largely by diffusion through clefts between the cells making up the capillary wall. This exchange is, accordingly, via extracellular pathways.
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© 1976 Plenum Press, New York
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Oldendorf, W.H. (1976). Certain Aspects of Drug Distribution to Brain. In: Levi, G., Battistin, L., Lajtha, A. (eds) Transport Phenomena in the Nervous System. Advances in Experimental Medicine and Biology, vol 69. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3264-0_9
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DOI: https://doi.org/10.1007/978-1-4684-3264-0_9
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