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Brain Barrier Pathology in Acute Arterial Hypertension

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Transport Phenomena in the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 69))

Abstract

Acute hypertension induced by various vasoactive substances can damage the blood-brain barrier (BBB) to protein in experimental animals. Thus, the brains from 27 out of 30 cats showed areas of extravasation of Evans blue-albumin after a systolic blood pressure increase exceeding 80 mm Hg induced by intravenous injection of metaraminol28. Similar lesions are seen in acute hypertension induced by angiotensin and noradrenaline. Approximately 70 per cent of rats developed BBB lesions after angiotension-provoked rise of the mean arterial blood pressure of 50–80 mm Hg 25 whereas a lower incidence has been reported in rabbits with the same vasoactive substance 6. The incidence of BBB lesions can be modified by several factors as will be discussed later. This might help to explain that some studies have failed to show permeability increase in acute hypertension (for a review of the literature see Johansson 197422.

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Author information

Authors and Affiliations

  1. Department of Neurology, Sahlgren Hospital, University of Goteborg, S-413 45, Goteborg, Sweden

    Barbro Johansson

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  1. Barbro Johansson
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Editors and Affiliations

  1. National Research Council, Rome, Italy

    Giulio Levi

  2. University of Padua Medical School, Padua, Italy

    Leontino Battistin

  3. Research Institute of Neurochemistry, New York, New York, USA

    Abel Lajtha

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© 1976 Plenum Press, New York

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Johansson, B. (1976). Brain Barrier Pathology in Acute Arterial Hypertension. In: Levi, G., Battistin, L., Lajtha, A. (eds) Transport Phenomena in the Nervous System. Advances in Experimental Medicine and Biology, vol 69. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3264-0_38

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  • DOI: https://doi.org/10.1007/978-1-4684-3264-0_38

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