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L-Dopa-Induced Hypotension: Depression of Spinal Sympathetic Neurons by Release of 5-Hydroxytryptamine

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Parkinson’s Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 90))

Abstract

In studies designed to determine the respective functional roles of two bulbospinal monoaminergic pathways to sympathetic preganglionic neurons, both L-dopa and precursors of 5-HT depressed transmission through excitatory spinal reflex and bulbospinal sympathetic pathways. Transmission through spinal reflex pathways was secondarily enhanced after L-dopa. Pharmacological tests indicated mediation of these effects by monoamines. After antagonism or depletion of central 5-HT, L-dopa only enhanced transmission through both pathways. The results indicate that hypotension and other sympathoinhibitory effects of L-dopa are produced at the spinal level by release of 5-HT from terminals of bulbospinal 5-HT pathways that are inhibitory to sympathetic preganglionic neurons. The excitatory effects of L-dopa are apparently mediated by release of catecholamines from bulbospinal noradrenergic pathways that are excitatory.

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Authors and Affiliations

  1. Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah, 84132, USA

    Donald N. Franz, Robert J. Neumayr & Bradford D. Hare

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  1. Donald N. Franz
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  2. Robert J. Neumayr
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  3. Bradford D. Hare
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Editors and Affiliations

  1. Departments of Pharmacology and Therapeutics and Psychiatry, Texas Tech University School of Medicine, Lubbock, Texas, USA

    Fathy S. Messiha Ph. D. (Associate Professor, Chairman) (Associate Professor, Chairman)

  2. Department of Pharmacology and Therapeutics, Tarbox Parkinson’s Disease Institute, Texas Tech University School of Medicine, Lubbock, Texas, USA

    Alexander D. Kenny Ph. D. (Professor and Chairman, Acting Director) (Professor and Chairman, Acting Director)

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© 1977 Plenum Press, New York

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Franz, D.N., Neumayr, R.J., Hare, B.D. (1977). L-Dopa-Induced Hypotension: Depression of Spinal Sympathetic Neurons by Release of 5-Hydroxytryptamine. In: Messiha, F.S., Kenny, A.D. (eds) Parkinson’s Disease. Advances in Experimental Medicine and Biology, vol 90. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2511-6_13

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  • DOI: https://doi.org/10.1007/978-1-4684-2511-6_13

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-2513-0

  • Online ISBN: 978-1-4684-2511-6

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