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Metabolic Effects of Gonadal Hormones and Contraceptive Steroids pp 97–125Cite as

Effects of Gonadal Hormones and Contraceptive Steroids on Glucose and Insulin Metabolism

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Abstract

Considerable data have been accumulated regarding the effect of naturally-occurring and synthetic sex steroids on glucose and insulin metabolism. The studies have been performed largely to elucidate the mechanisms responsible for changes in carbohydrate metabolism during pregnancy. Initially, studying glucose tolerance in women treated with contraceptive steroids seemed to be a logical way to dissociate the effects of gonadal steroids from the metabolic effects of human placental lactogen during gestation. However, such studies have been confusing and often apparently contradictory. Yet, if the structural characteristics of the steroid compounds tested are considered, these results are basically in agreement with, rather than contradictory to, data obtained earlier in laboratory animals. If one correlates the changes in glucose or insulin metabolism with the chemical structure of the estrogen or progestin tested, it is possible to show that there are clear structure-activity relationships between the compounds tested and the results observed, which appear to be modified by the functional state of the pancreatic islet cells in the subjects tested.

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Author information

Authors and Affiliations

  1. Endocrinology Division, Department of Medicine, School of Medicine, University of Colorado, Denver, Colorado, USA

    Paul Beck

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  1. Paul Beck
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Editors and Affiliations

  1. Harvard Medical School, USA

    Hilton A. Salhanick (Professor of Obstetrics and Gynecology, Member) (Professor of Obstetrics and Gynecology, Member)

  2. Center for Population Studies, Harvard School of Public Health, USA

    Hilton A. Salhanick (Professor of Obstetrics and Gynecology, Member) (Professor of Obstetrics and Gynecology, Member)

  3. Washington University School of Medicine, USA

    David M. Kipnis (Professor of Medicine) (Professor of Medicine)

  4. College of Physicians and Surgeons, Columbia University, USA

    Raymond L. Vande Wiele (Professor of Obstetrics and Gynecology) (Professor of Obstetrics and Gynecology)

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© 1969 Plenum Press, New York

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Beck, P. (1969). Effects of Gonadal Hormones and Contraceptive Steroids on Glucose and Insulin Metabolism. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_9

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  • DOI: https://doi.org/10.1007/978-1-4684-1782-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1784-5

  • Online ISBN: 978-1-4684-1782-1

  • eBook Packages: Springer Book Archive

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