Abstract
It is now well known that there are tiny membrane-limited channels ramifying throughout the cytoplasm of most cells. Porter (24) was the first to describe this lace-like reticulum of membranes with the electron microscope. Because of its association with the endoplasmic portion of the cell rather than the ectoplasm, it was referred to as the “endoplasmic reticulum” (25,26). In 1955, Fawcett (7) noted that two forms of the endoplasmic reticulum existed in the hepatic parenchymal cell. One form consisted of a system of membranes studded with ribosomes (rough-surfaced endoplasmic reticulum) and the other consisted of only a membranous network (smooth-surfaced endoplasmic reticulum).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cardell, R.R. Subcellular alterations in rat liver following hypophysectory. Biochem. Biophys. Acta 148:539 (1967).
Conney, A.H. Pharmacological implications of microsomal enzyme induction. Pharm. Rev. 19: 317 (1967).
Conney, A.H., Schneidman, K., Jacobson, M., and Kuntzman, R. Drug induced changes in steroid metabolism. Am. N.Y. Acad. Sci. 123: (Art. 1) 98 (1965).
Dallner, D., and Emster, L. Sub fractionation and composition of microsomal membranes: A review. J. Histochem. Cytochem. 16:611 (1968).
Emans, J.B., and Jones, A.L. Hypertrophy of liver cell smooth surfaced reticulum following progesterone administration. J. Histochem. Cytochem. 16:561 (1968).
Fouts, J.R., Rogers, L.A., and Gram, T.E. The metabolism of drugs by hepatic microsomal enzymes. Studies on intramicroso- mal distribution of enzymes and relationships between enzyme activity and structure of the hepatic endoplasmic reticulum. Exp. Molec. Path. 5:475 (1966).
Fawcett, D.W. Obsearvations on the cytology and electron microscopy of hepatic cells. J. Nat. Cancer Inst. 15:1475 (1955).
Fawcett, D.W. Structural and functional variations in the membranes of the cytoplasm. In Intracellular Membraneous Structure, p. 15. Japan Society for Cell Biology, Okayama (1965).
Glaumann, H., and Dallner, G. Lipid composition and turnover of rough and smooth microsomal membranes in rat liver. J. Lipid Res. 1:720 (1968).
Granick, S. The induction in vitro of the synthesis of δ aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. J. Biol. Chem. 241: 1359 (1966).
Hutterer, F., Schaffner, F., Klion, F.M., and Popper, H. Hypertrophie, hypoactive smooth endoplasmic reticulum: a sensitive indicator of hepatotoxicity exemplified by Dieldrin. Science 161:1017 (1968).
Jick, H., and Shuster, L. The turnover of microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome reductase in the livers of mice treated with phenobarbital. J. Biol. Chem. 241:5366 (1966).
Jones, A.L., and Armstrong, D.T. Increased cholesterol biosynthesis following phenobarbital induced hypertrophy of agranular reticulum in liver. Proc. Soc. Exp. Biol. Med. 119: 1136 (1965).
Jones, A.L., and Fawcett, D.W. Hypertrophy of the agranular endoplasmic reticulum in hamster liver induced by phenobarbital (with a review on the function of this organelle in liver). J. Histochem. Cytochem. 14: 215 (1966).
Jones, A.L., Ruderman, N.B., and Herrera, M.G. Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J. Lipid Research 8: 429 (1967).
Kadenback, B. Synthesis of mitochondrial proteins: demonstration of a transfer of proteins from microsomes into mitochondria. Biochem. Biophys. Acta 134:430 (1966).
Kuntzman, R., Lawrence, D., and Conney, A.H. Michaelis constants for the hydroxylation of steroid hormones and drugs by rat liver microsomes. Molec. Pharmacol. 1:163 (1965).
Marver, H.S., Tschudy, D.P., Perlroth, M.G., and Collins, A. 6 aminolevulinic acid synthetase: I. Studies in liver homogenates. J. Biol. Chem. 241:2803 (1966).
Marver, H.S., Tschudy, D.P., Perlroth, M.G., and Collins, A. 6 aminolevulinic acid synthetase: II. Induction in rat liver. J. Biol. Chem. 241:4323 (1966).
McKay, R., Druyan, R., and Rabinowity, M. Intramitochondrial loci for 6 aminoleuvulinic acid synthetase and ferrochelatase. Fed. Proceed. 27: 774 (1968).
Omura, T., and Sato, R. The carbon monoxide binding pigment of liver microsomes. J. Biol. Chem. 239:2370 (1964).
Orrenius, S., and Ericsson, J.L.E. Enzyme-menibrane relationship in phenobarbital induction of synthesis of drug- metabolizing enzyme system and proliferation of endoplasmic reticulum. J. Cell Biol. 28: 181 (1966).
Orrenius S., and Ericsson, J.L.E. On the relationship of liver glucose-6-phosphatase to the proliferation of endoplasmic reticulum in phenobarbital induction. J. Cell Biol. 31:243 (1966).
Porter, K.R., Clause, A., and Fullam, E.F. A study tissue of culture cells by electron microscopy. J. Exp. Med. 81:233 (1945).
Porter, K.R., and Thompson, H.P. A particulate body associated with epithelial cells cultured from mammary carcinomas of mice of a milk-factor strain. J. Exp. Med. 88:15 (1948).
Porter, K.R. Observations on a submicroscopic basophilic component of cytoplasm. J. Exp. Med. 27:727 (1953).
Posalaki, Z., and Barka, T. Alterations of hepatic endoplasmic reticulum in porphyric rats. J. Histochem. Cytochem. 16:337 (1968).
Schimke, R.T., Ganschow, R., Doyle, D., and Arias, I.M. Regulation of protein turnover in mammalian tissues. Fed. Proceed. 27: 1223 (1968).
Shuster, L., and Jick, H. The turnover of microsomal protein in the livers of phenobarbital-treated mice. J. Biol. Chem. 241:5361 (1966).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1969 Plenum Press, New York
About this chapter
Cite this chapter
Jones, A.L., Emans, J.B. (1969). The Effects of Progesterone Administration on Hepatic Endoplasmic Reticulum: An Electron Microscopic and Biochemical Study. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_7
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1782-1_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1784-5
Online ISBN: 978-1-4684-1782-1
eBook Packages: Springer Book Archive