Abstract
Viral etiology is well established for at least two chronic progressive CNS diseases in man. Subacute sclerosing panencephalitis (SSPE) is a rare late complication of childhood measles characterized by a long time span between the initial attack and the onset of SSPE. This latent or silent phase may be a decade or longer, and the interaction between virus and host during this interval is poorly understood (1).
This work was supported by USPHS grants NS12428 and AI16102. M.J.M. Koolen is the recipient of a long-term fellowship from EMBO.
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Keywords
- Progressive Multifocal Leukoencephalopathy
- Canine Distemper Virus
- Mouse Hepatitis Virus
- Subacute Sclerosing Panencephalitis
- Scripps Clinic
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1987 Plenum Press, New York
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Buchmeier, M.J., Dalziel, R.G., Koolen, M.J.M., Lampert, P.W. (1987). Molecular Determinants of CNS Virulence of MHV-4. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_38
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