Abstract
The purpose of this study is to compare specific regions of the nucleocapsid mRNA for murine coronavi ruses and to determine if any differences are associated with differences in pathogenicity. Murine hepatitis viruses (MHV) differ in the types of diseases they produce in rodents (see review1). In particular, MHV-JHM, causes demyelinating lesions in the central nervous system of many strains of rats while MHV-3 does not. MHV-A59 and MHV-S causes chronic demyelinating disease in mice. MHV-1 causes hepatitis in weanling VS mice.
Chapter PDF
Similar content being viewed by others
Keywords
- Demyelinating Disease
- Central Nervous System Infection
- Nucleocapsid Protein
- Synthetic Oligonucleotide
- Murine Hepatitis Virus
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
M. Piazza, Analogies Between Human and Animal Viral Hepatitis, in: “Experimental Viral Hepatitis,” Charles C. Thomas, Springfield (1969).
J. O. Fleming, S. A. Stohlman, R. C. Harman, M. M. C. Lai, J. A. Frelinger, and L. P. Weiner, Antigenic Relationship of Murine Coronavirus. Analysis Using Monoclonal Antibodies to JHM (MHV-4) Virus, Virology, 131: 296 (1983).
M. J. Buchmeier, H. A. Lewicki, P. J. Talbot, R. L. Knobler, Murine Hepatitis Virus-4 (Strain JHM)-Induced Neurologic Disease Is Modulated In Vivo by Monoclonal Antibodies, Virology, 132: 261 (1984).
J. Armstrong, S. Smeekens, and P. Rottier, Sequence of the Nucleocapsid Gene from Murine Coronavirus MHV-A59, Nuc. Acid Res., 11: 883 (1983).
M. A. Skinner, and S. G. Siddell, Coronavirus JHM: Nucleotide Sequence of the mRNA that Encodes Nucleocepsid Protein, Nuc. Acid Res., 11: 5045 (1983).
D. Parham, A. Tereba, P. J. Talbot, D. P. Jackson, V. L. Morris, Analysis of JHM Central Nervous System Infections in Rats, Arch Neurol., 43: 702 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Kooi, C., Wallace, T., Lee Chan, E.C.M., Morris, V.L. (1987). Are Differences in Biological Properties of MHV Associated with Differences in Specific Regions of their Nucleocapsid mRNA?. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_31
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1280-2_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1282-6
Online ISBN: 978-1-4684-1280-2
eBook Packages: Springer Book Archive