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Numerical Sex-Chromosome Anomalies in Mammals: Their Spontaneous Occurrence and Use in Mutagenesis Studies

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Chemical Mutagens

Part of the book series: Chemical Mutagens

Abstract

Mutagenesis testing in intact mammals is increasingly becoming a prerequisite to any decision making that involves risk estimates. While the production of dominant lethals has been widely used as a convenient indicator of chromosomal damage, the interpretation of comparative experiments employing this method may be complex, especially when females are exposed and mutagenic effects must be distinguished from physiological ones acting via the mother. For this reason, other simple methods for measuring inherited chromosomal damage in the intact mammal have been developed.

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  1. Biology Division, Oak Ridge National Laboratory, 37830, Oak Ridge, Tennessee, USA

    Liane Brauch Russell

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  1. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

  2. University of Tennessee, Knoxville, Tennessee, USA

    Alexander Hollaender

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Russell, L.B. (1976). Numerical Sex-Chromosome Anomalies in Mammals: Their Spontaneous Occurrence and Use in Mutagenesis Studies. In: Hollaender, A. (eds) Chemical Mutagens. Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0892-8_3

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  • DOI: https://doi.org/10.1007/978-1-4684-0892-8_3

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