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Sequential Events in Chemical Carcinogenesis

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Book cover Etiology: Chemical and Physical Carcinogenesis

Part of the book series: Cancer, A Comprehensive Treatise ((C))

Abstract

It has become increasingly evident that the vast majority of if not all cancers develop slowly as a multistep process in which discrete focal new cell populations appear sequentially as possible precursor lesions for the next step (Foulds, 1969, 1975; Farber, 1973a; Farber and Cameron, 1980; Farber and Sporn, 1976; Medline and Farber, 1980). The multistep patterns appear to occur in most known instances of cancer induced by chemicals and radiations and by some viruses (Foulds, 1975; Farber and Cameron, 1980; Peto, 1977). The field has been reviewed by Foulds (1969, 1975) in extenso and more recently by Farber and Cameron (1980) and there is no need for an additional comprehensive review at this time. However, it does appear to be appropriate to consider analytically and critically some of the component processes in chemical carcinogenesis and to discuss some emerging general principles that seem to be pertinent to the further study of mechanisms of cancer development with chemicals.

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Authors and Affiliations

  1. Departments of Pathology and Biochemistry, University of Toronto, Toronto, Ontario, Canada

    Emmanuel Farber

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  1. Emmanuel Farber
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Editors and Affiliations

  1. Department of Anatomic and Research Pathology, M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

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Farber, E. (1982). Sequential Events in Chemical Carcinogenesis. In: Becker, F.F. (eds) Etiology: Chemical and Physical Carcinogenesis. Cancer, A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6598-7_13

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  • DOI: https://doi.org/10.1007/978-1-4615-6598-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6600-7

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