Skip to main content
SpringerLink
Log in

Some Effects of Carcinogens on Cell Organelles

  • Chapter
Book cover Etiology: Chemical and Physical Carcinogenesis

Part of the book series: Cancer, A Comprehensive Treatise ((C))

  • 21 Accesses

Abstract

In the first edition of this chapter, several acute and chronic effects of selected hepatocarcinogens on the histology and ultrastructure of rodent liver cells were reviewed briefly. That review covered the period from the emergence of the application of ultrastructural studies to the problem of carcinogenesis in the early 1960s through publications available in 1972. The purpose of this chapter is to present several observations regarding effects of carcinogens on cell ultrastructure that have been published from 1972 through 1979 and to update our present knowledge in this area by relating the more recent publications to those discussed previously.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agrelo, C., 1978, The effect of carcinogens on the nuclear size of HeLa cells, Toxicology 9: 21.

    Article  CAS  PubMed  Google Scholar 

  • Allison, A., 1969, Lysosomes and cancer, in: Lysosomes in Biology and Pathology, Vol. 2 ( J. L. Dingle and H. Fell, eds.), pp. 178–204, American Elsevier, New York.

    Google Scholar 

  • Allison, A., And Mallucci, L., 1964, Lysosomes in dividing cells, with special reference to lymphocytes, Lancet 2: 1371.

    Article  CAS  PubMed  Google Scholar 

  • Althoff, J., Pour, P., Malick, L., And Wilson, R., 1976, Pancreatic neoplasms induced in Syrian golden hamsters. I. Scanning electron microscopic observations, Am. J. Pathol. 83: 517.

    CAS  PubMed  Google Scholar 

  • Anderson, H., Nehring, E., And Wichser, W., 1975, Affatoxin contamination of corn in the field, J. Agric. Food Chem. 23: 775.

    Article  CAS  PubMed  Google Scholar 

  • Anghileri, L., Heidbreden, M., Weiler, G., And Dermietzel, R., 1977, Hepatocarcinogenesis by thioacetamide: Correlations of histological and biochemical changes, and possible role of cell injury, Exp. Cell Biol. 45: 34.

    CAS  PubMed  Google Scholar 

  • Apffel, C., 1978, The endoplasmic reticulum membrane system and malignant neoplasia, in Progress in Experimental Tumor Research, Vol. 22 ( D. Walbach, ed.), pp. 317–362, Karger, Basel.

    Google Scholar 

  • Arstila, A., And Trump, B., 1972, Ethionine induced alterations in the Golgi apparatus and in the endoplasmic reticulum, Virchows Arch. B 10: 344.

    CAS  Google Scholar 

  • Bannasch, P., 1968, The cytoplasm of hepatocytes during carcinogenesis. Electron and light micro-scopical investigations of the nitrosomorpholine-intoxicated rat liver, Recent Results Cancer Res. 19: 1.

    Google Scholar 

  • Bauer, L., Talusan, A., And Muller, E., 1972, Ultrastructural changes produced by the carcinogen, aflatoxin B, in different tissues, Virchows Arch. B 10: 275.

    Google Scholar 

  • Berg, T., And Christoffersen, T., 1974, Early changes induced by 2-acetylaminofluorene in lysosomes in rat liver parenchymal cells, Biochem. Pharmacol. 23: 3323.

    Article  CAS  PubMed  Google Scholar 

  • Bernhard, W., Frayssinet, C., Lafarge, C., And Lebreton, E., 1965, Lesions nucleolaires precoces provoquees par l’aflatoxine dans les cellules hepatiques du rat, C. R. Acad. Sci. 261: 1785.

    CAS  Google Scholar 

  • Borenfreund, E., And Higgins, P., 1979, Aggregates of intermediate type filaments in carcinogen-induced cytoplasmic lesions in rat liver cells, In Vitro 15: 228.

    Google Scholar 

  • Brandes, D., Sloan, K., Anton, E., And Bloedorn, F., 1967, The effects of X-irradiation on the lysosomes of mouse mammary gland carcinoma, Cancer Res. 27: 731.

    CAS  PubMed  Google Scholar 

  • Busch, H., And Smetana, K., 1970, The Nucleolus, Academic Press, New York.

    Google Scholar 

  • Butler, W., 1966, Early hepatic parenchymal changes induced in the rat by aflatoxin B, Am. J. Pathol. 49: 113.

    CAS  PubMed  Google Scholar 

  • Butler, W., And Hard, G., 1976, Chemical carcinogenesis: Early biological responses in induced carcinogenesis in the kidney, in: The Prediction of Chronic Toxicity from Short Term Studies, Proceedings of the European Society of Toxicology, Vol. 17 ( W. Dundan, B. Leonard, and M. Brunaud, eds.), pp. 34–38, American Elsevier, New York.

    Google Scholar 

  • Butler, W., And Lijinsky, W., 1970, Acute toxicity of aflatoxin G1 to the rat, J. Pathol. 102: 209.

    Article  CAS  PubMed  Google Scholar 

  • Butler, W., Greenblatt, M., And Lijinsky, W., 1969, Carcinogenesis in rats by aflatoxins B1, G1 and B2, Cancer Res. 29: 2206.

    CAS  PubMed  Google Scholar 

  • Campbell, T., Sinnhuber, R., Lee, D., Wales, J., And Salamat, L., 1974, Hepatocarcinogenic material in urine specimens from humans consuming aflatoxin, J. Natl. Cancer Inst. 52: 1647.

    CAS  PubMed  Google Scholar 

  • Clifford, J., And Rees, J., 1966, Aflatoxin: A site of action in the rat liver cell, Nature (London) 209: 312.

    Article  CAS  Google Scholar 

  • Cloyd, M., And Bigner, D., 1977, Surface morphology of normal and neoplastic rat cells, Am. J. Pathol. 88: 29.

    CAS  PubMed  Google Scholar 

  • Collard, J., And Temmink, J., 1976, Surface morphology and agglutinability with concanavalin A in normal and transformed murine fibroblasts, J. Cell Biol. 68: 101.

    Article  CAS  PubMed  Google Scholar 

  • Date, P., Gothoskar, S., And Bhide, S., 1976, Effect of partial hepatectomy on tumor incidence and metabolism of mice fed thioacetamide, J. Natl. Cancer Inst. 56: 493.

    CAS  PubMed  Google Scholar 

  • Derenzini, M., And Moyne, G., 1978, The nucleolar origin of certain perichromatin-like granules: A study with alpha-amanitin, J. Ultrastruct. Res. 62: 213.

    Article  CAS  PubMed  Google Scholar 

  • Dobre, M., Moraru, I., Cotutiu, C., And Motoc, F., 1976, Nuclear inclusions and other ultrastruc-tural aspects in the liver of animals treated with N-2-acetylaminofluorene, Pathol. Eur. 11: 63.

    CAS  Google Scholar 

  • Emmelot, P., 1973, Biochemical properties of normal and neoplastic cell surfaces: A review, Eur. J. Cancer 9: 319.

    Article  CAS  PubMed  Google Scholar 

  • Emmelot, P., And Benedetti, E., 1961, Some observations on the effect of liver carcinogens on the fine structure and function of the endoplasmic reticulum of rat liver, in: Protein Biosynthesis ( R. Harris, ed.), pp. 99–123, Academic Press, New York.

    Google Scholar 

  • Epstein, S., Ito, N., Merkow, L., And Farber, E., 1967, Cellular analysis of liver carcinogenesis: The induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism, Cancer Res. 27: 1702.

    CAS  PubMed  Google Scholar 

  • Farber, E., 1963, Ethionine carcinogenesis, Adv. Cancer Res. 7: 383.

    Article  CAS  PubMed  Google Scholar 

  • Firminger, H., And Mulay, A., 1952, Histochemical and morphologic differentiation of induced tumors of the liver in rats, J. Natl. Cancer Inst. 13: 19.

    CAS  PubMed  Google Scholar 

  • Flaks, B., 1970, Changes in the fine structure of rat hepatocytes during the early phases of chronic 2-acetylaminofluorene intoxication, Chem. Biol. Interact. 2: 129.

    Article  CAS  PubMed  Google Scholar 

  • Flaks, B., 1971, Fine structure of rat hepatocytes during the late phase of chronic 2-acetylaminofluorene intoxication, Chem. Biol. Interact. 3: 157.

    Article  CAS  PubMed  Google Scholar 

  • Fouts, J., And Rogers, L., 1965, Morphological changes in the liver accompanying stimulation of microsomal drug metabolizing enzyme activity by phenobarbital, chlordane, benzpyrene or methylcholanthrene in rats, J. Pharmacol. Exp. Ther. 147: 112.

    CAS  PubMed  Google Scholar 

  • Frasca, J., Auerbach, O., Parks, V., And Jamieson, J., 1968a, Electron microscopic observations of the bronchial epithelium of dogs. I. Control dogs, Exp. Mol. Pathol. 9: 363.

    Article  CAS  PubMed  Google Scholar 

  • Frasca, J., Auerbach, O., Parks, V., And Jamieson, J., 1968, Electron microscopic observations of the bronchial epithelium of dogs. II. Smoking dogs, Exp. Mol. Pathol. 9: 380.

    Article  CAS  PubMed  Google Scholar 

  • Friedell, G., Jacobs, J., Nagy, G., And Cohen, S., 1977, The pathogenesis of bladder cancer, Am. J. Pathol. 89: 431.

    CAS  PubMed  Google Scholar 

  • Friend, D., And Farquhar, M., 1967, Functions of coated vesicles during protein absorption in the rat vas deferens, J. Cell Biol. 35: 357.

    Article  CAS  PubMed  Google Scholar 

  • Fuller, G., Spooncer, W., King, A., Schade, J., And Mackey, B., 1977, Survey of aflatoxins in California tree nuts, J. Am. Oil Chem. Soc. 54: 231A.

    Article  CAS  Google Scholar 

  • Harris, C., Sporn, M., Kaufman, D., Smith, J., Baker, M., And Saffiotti, U., 1971, Acute ultrastructural effects of benzo(a)pyrene and ferric oxide on the hamster tracheobronchial epithelium, Cancer Res. 31: 1977.

    Google Scholar 

  • Harris, C., Sporn, M., Kaufman, D., Smith, J., Jackson, F., And Saffiotti, U., 1972, Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene—ferric oxide, J. Natl. Cancer Inst. 48: 743.

    CAS  PubMed  Google Scholar 

  • Harris, C., Kaufman, D., Sporn, M., Smith, J., Jackson, F., And Saffiotti, U., 1973a, Ultrastructural effects of N-methyl-N-nitrosourea on the tracheobronchial epithelium of the Syrian golden hamster, Int. J. Cancer 12: 259.

    Article  CAS  PubMed  Google Scholar 

  • Harris, C., Kaufman, D., Sporn, M., Boren, H., Jackson, F., Smith, J., Pauley, J., Dedick, P., And Saffiotti, U., 1973, Localization of benzo(a)pyrene-5H and alterations in nuclear chromatin caused by benzo(a)pyrene—ferric oxide in the hamster respiratory epithelium, Cancer Res. 33: 2842.

    CAS  PubMed  Google Scholar 

  • Harris, C., Kaufman, D., Jackson, F., Smith, J., Dedick, P., And Saffiotti, U., 1974a, Atypical cilia in the tracheobronchial epithelium of the hamster during respiratory carcinogenesis, J. Pathol. 114: 17.

    Article  CAS  PubMed  Google Scholar 

  • Harris, J., Price, M., And Willison, M., 1974b, A comparative study on rat liver and hepatoma nuclear membranes, J. Ultrastruct. Res. 48: 17.

    Google Scholar 

  • Harris, C., Frank, A., Van Haaften, C., Kaufman, D., Connor, R., Jackson, F., Barrett, L., Mcdowell, E., And Trump, B., 1976, Binding of [3H]benzo[a]pyrene to Dna in cultured human bronchus, Cancer Res. 36: 1011.

    CAS  PubMed  Google Scholar 

  • Havel, J., And Kane, J., 1973, Drugs and lipid metabolism, Annu. Rev. PharmacoL 13: 287.

    Article  CAS  Google Scholar 

  • Herdson, P., Garvin, P., And Jennings, R., 1964, Reversible biological and fine structural changes produced in rat liver by a thiohydantoin compound, Lab. Invest. 13: 1014.

    CAS  PubMed  Google Scholar 

  • Herrold, K., 1969, Aflatoxin induced lesions in Syrian hamsters, Br. J. Cancer 23: 655.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hess, R., Staubli, W., And Riess, W., 1965, Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat, Nature (London) 208: 856.

    Article  CAS  Google Scholar 

  • Hicks, R., 1976, Changes in differentiation of the urinary bladder during benign and neoplastic hyperplasia, in Progress in Differentiation Research ( N. Muller-Berat, C. Rosenfeld, D. Tarin, and D. Viza, eds.), pp. 339–353, North-Holland, Amsterdam.

    Google Scholar 

  • Hicks, R., And Wakefield, J., 1976, Membrane changes during urothelial hyperplasia and neoplasia, Cancer Res. 36: 2502.

    CAS  PubMed  Google Scholar 

  • Hirao, K., Matsumura, K., Imagawa, A., Enomoto, Y., Hosogi, Y., Kani, T., Fugikawa, K., And

    Google Scholar 

  • Ito, N., 1974, Primary neoplasms in dog liver induced by diethylnitrosamine, Cancer Res. 34: 1870.

    Google Scholar 

  • Hodges, G., Hicks, R., And Spacey, G., 1976, Scanning electron microscopy of cell-surface changes in methylnitrosourea (Mnu)-treated rat bladders in vivo and in vitro, Differentiation 6: 143.

    Article  CAS  Google Scholar 

  • Hruban, Z., Swift, H., Dunn, F., And Lewis, D., 1965, Effect of ß-3-furylalanine on the ultrastructure of the hepatocytes and pancreatic acinar cells, Lab. Invest. 14: 70.

    CAS  PubMed  Google Scholar 

  • Jacobs, J., Arai, M., Cohen, S., And Friedell, G., 1976a, Early lesions in experimental bladder cancer: Scanning electron microscopy of cell surface markers, Cancer Res. 36: 2512.

    CAS  PubMed  Google Scholar 

  • Jacobs, J., Arai, M., Cohen, S., And Friedell, G., 1976b, Light and scanning electron microscopy of exfoliated bladder epithelial cells in rats fed N-[4-(5-nitro-2-furyl)2-thiazolyllformamide, J. Natl. Cancer Inst. 57: 63.

    CAS  PubMed  Google Scholar 

  • Jacobs, J., Arai, M., Cohen, S., And Friedell, G., 1977, A long term study of reversible and progressive urinary bladder cancer lesions in rats fed N-[4-(5-nitro-2-furyl)2-thiazolyl]formamide, Cancer Res. 37: 2817.

    CAS  PubMed  Google Scholar 

  • Kahan, B., Rutzky, L., Kahan, A., Oyasu, R., Wiseman, F., And Legrue, S., 1977, Cell surface changes associated with malignant transformation of bladder epithelium in vitro, Cancer Res. 37: 2866.

    CAS  Google Scholar 

  • Karasaki, S., 1969, The fine structure of proliferating cells in preneoplastic rat livers during azo-dye carcinogenesis, J. Cell BioL 40: 322.

    Article  CAS  PubMed  Google Scholar 

  • Ketterer, B., Holt, S., And Ross-Mansell, P., 1967, The effect of a single intraperitoneal dose of the hepatocarcinogen 4-dimethylaminoazobenzene on the rough-surfaced endoplasmic reticulum of the liver of the rat, Biochem. J. 103: 692.

    CAS  PubMed  Google Scholar 

  • Kim, C., Kim, D., And Lee, Y., 1972, Fine structural changes and autoradiographic studies of rat liver cells induced by aflatoxin B1 and GI, Yonsei Med. J. 13: 1.

    CAS  PubMed  Google Scholar 

  • Kingsbury, J., 1964, Poisonous Plants of the U.S. and Canada, pp. 425–435, Prentice–Hall, Englewood Cliffs, N.J.

    Google Scholar 

  • Koshiba, K., Thirumalachary, C., Daskal, Y., And Busch, H., 1971, Ultrastructural and biochemical studies on ribonucleoprotein particles from isolated nucleoli of thioacetamide-treated rat liver, Exp. Cell Res. 68: 235.

    Article  CAS  PubMed  Google Scholar 

  • Koss, L., 1977, Some ultrastructural aspects of experimental and human carcinoma of the bladder, Cancer Res. 37: 2824.

    CAS  PubMed  Google Scholar 

  • Krishnamachari, K., Nagarajan, V., Bhat, R., And Tilak, T., 1975, Hepatitis due to aflatoxicosis: An outbreak in Western India, Lancet 1: 1061.

    Article  CAS  PubMed  Google Scholar 

  • Lafontaine, J., And Allard, C., 1964, A light and electron microscope study of the morphological changes induced in rat liver cells by the azo dye 2-Me-Dab, J. Cell Biol. 22: 143.

    Article  CAS  PubMed  Google Scholar 

  • Lazarow, P., 1978, Rat liver perixosomes catalyze the /3-oxidation of fatty acids, J. Biol. Chem. 253: 1522.

    CAS  PubMed  Google Scholar 

  • Lee, K., And Goodall, C., 1968, Methylation of ribonucleic acid and deoxyribonucleic acid and tumour induction in livers of hypophysectomized rats treated with dimethylnitrosamine, Biochem. f. 106: 767.

    CAS  Google Scholar 

  • Levitt, M., Harris, C., Squire, R., Springer, S., Wenk, M., Mollelo, C., Thomas, D., Kingsbury, E., And Newkirk, C., 1977, Experimental pancreatic carcinogenesis. I. Morphogenesis of pancreatic adenocarcinoma in the Syrian golden hamster induced by N-nitroso-bis(2-hydroxypropyl)amine, Am. J. Pathol. 88: 5.

    CAS  PubMed  Google Scholar 

  • Lillehoj, E., Kwolek, W., Fennell, D., And Milburn, M., 1975a, Aflatoxin incidence and association with bright greenish-yellow fluorescence and insect damage in a limited survey of freshly harvested high-moisture corn, Cereal Chem. 52: 403.

    Google Scholar 

  • Lillehoj, E., Kwolek, W., Shannon, G., Shotwell, O., And Hesseltine, C., 19756, Aflatoxin occurrence in 1973 field corn. I. A limited survey in the southeastern U.S., Cereal Chem. 52: 603.

    Google Scholar 

  • Lillehoj, E., Fennell, D., And Kwolek, W., 1976, Aspergillus flavus and aflatoxin in Iowa corn before harvest, Science 193: 495.

    CAS  Google Scholar 

  • Lin, J., Liu, C., And Svoboda, D., 1974, Long term effects of aflatoxin B1 and viral hepatitis on marmoset liver. A prelimanry report, Lab. Invest. 30: 267.

    CAS  PubMed  Google Scholar 

  • Linsell, C., And Peers, F., 1977, Aflatoxin and liver cell cancer, Trans. R. Soc. Trop. Med. Hyg. 71:471. Longnecker, D., And Curphey, T., 1975, Adenocarcinoma of the pancreas in azaserine-treated rats, Cancer Res. 35: 2249.

    Google Scholar 

  • Loud, A., 1968, A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells, J. Cell Biol. 37: 27.

    Article  CAS  PubMed  Google Scholar 

  • Louria, D., Finkel, G., Smith, J., And Buse, M., 1974, Aflatoxin-induced tumors in mice, Sabouraudia 12: 371.

    CAS  PubMed  Google Scholar 

  • Magee, P., 1963, Cellular injury and chemical carcinogenesis by N-nitroso compounds, in: Cancer Progress, Vol. 1963 ( R. Raven, ed). pp. 56–66, Butterworths, London.

    Google Scholar 

  • Magee, P., And Barnes, J., 1967, Carcinogenic nitroso compounds, in: Advances in Cancer Research, Vol. 10 ( A. Hadlow and S. Weinhouse, eds.), pp. 163–246, Academic Press, New York.

    Google Scholar 

  • Maini, M., And Stich, H., 1961, Chromosomes of tumor cells. H. Effects of various liver carcinogens on mitosis of hepatic cells, J. Natl. Cancer Inst. 26: 1413.

    CAS  PubMed  Google Scholar 

  • Masters, C., And Holmes, R., 1977, Peroxisomes: New aspects of cell physiology and biochemistry, Physiol. Rev. 57: 816.

    CAS  PubMed  Google Scholar 

  • Masters, C., And Holmes, R., 1979, Peroxisomes—Their metabolic roles in mammalian tissues, Trends Biochem. Sci. 4: 233.

    Article  CAS  Google Scholar 

  • Mclean, E., 1970, The toxic actions of pyrrolizidine (Senecio) alkaloids, Pharmacol. Rev. 22: 429.

    CAS  PubMed  Google Scholar 

  • Meldolesi, J., Clementi, F., Chiesara, E., Conti, F., And Fanti, A., 1967, Cytoplasmic changes in rat liver after prolonged treatment with low doses of ethionine and adenine, Lab. Invest 17: 265.

    CAS  PubMed  Google Scholar 

  • Miyai, K., And Ritchie, A., 1970, Natural resolution of hepatic ultrastructural changes induced by DL-ethionine, Am. J. Pathol. 61: 211.

    CAS  PubMed  Google Scholar 

  • Miyai, K., And Steiner, J., 1965, Fine structure of interphase liver cell nuclei in subacute ethionine intoxication, Exp. Mol. Pathol. 4: 525.

    Article  CAS  PubMed  Google Scholar 

  • Monneron, A., 1969, Experimental induction of helical polysomes in adult rat liver, Lab. Invest. 20: 178.

    CAS  PubMed  Google Scholar 

  • Monneron, A., Liew, C., And Allfrey, V., 1971, Isolation and biological activity of mammalian helical polyribosomes, J. Mol. Biol. 57: 335.

    Article  CAS  PubMed  Google Scholar 

  • Mukherjee, T., Gustafsson, R., Afzelius, B., And Arrhenius, E., 1963, Effects of carcinogenic amines on amino acid incorporation by liver systems. II. A morphological and biochemical study on the effect of dimethylnitrosamine, Cancer Res. 23: 944.

    Google Scholar 

  • Nair, V., Casper, R., Siegel, S., And Bau, D., 1970, Regulation of the diurnal rhythm in hepatic drug metabolism, Fed. Proc. 29:804

    Google Scholar 

  • Nettesheim, P., And Griesemer, R., 1978, Experimental models for studies of respiratory tract carcinogenesis, in: Pathogenesis and Therapy of Lung Cancer (C. Harris, ed.), pp. 75–188, Dekker, New York.

    Google Scholar 

  • Newberne, P., And Wogan, G., 1968, Sequential morphologic changes in aflatoxin B1 carcinogenesis in the rat, Cancer Res. 28:770.

    Google Scholar 

  • Newman, J., And Hicks, R., 1977 Detection of neoplastic and preneoplastic urothelia by combined scanning and transmission electron microscopy of urinary surface on human and rat bladders, Histopathology 1: 125.

    Google Scholar 

  • Nicolson, G., 1976, Transmembrane control of the receptors on normal and tumor cells. I. Cytoplasmic influence over cell surface components, Biochim. Biophys. Acta 457: 57.

    Google Scholar 

  • Nigam, V., 1965, Glycogen metabolism in liver during Dab carcinogenesis, Br. J. Cancer 19: 912.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Novikoff, A., 1976, The endoplasmic reticulum: A cytochemist’s view (a review), Proc. Natl. Acad. Sci. Usa 73: 2781.

    Article  CAS  PubMed  Google Scholar 

  • Novikoff, A., And Shin, W., 1964, The endoplasmic reticulum in the Golgi zone and its relation to microbodies, Golgi apparatus and autophagic vacuoles in rat liver cells, J. Microsc. (Oxford) 3: 187.

    Google Scholar 

  • Noyes, W., 1975, Aflatoxin-induced changes in human hepatocytes in organ culture, Proc. Am. Assoc. Cancer Res. 16: 26.

    Google Scholar 

  • Okazaki, K., Shull, K., And Farber, E., 1968, Effects of ethionine on adenosine triphosphate levels and ionic composition of liver cell nuclei, J. Biol. Chem. 243: 4661.

    CAS  PubMed  Google Scholar 

  • Olason, D., And Smuckler, E., 1976, Changes in hepatic nuclei induced by acetamide and thioacetamide, Arch. Pathol. Lab. Med. 100: 415.

    CAS  PubMed  Google Scholar 

  • Opie, E. L., 1944, The pathogenesis of tumors of the liver produced by butter yellow, J. Exp. Med. 80: 231.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Orrenius, S., And Ericsson, J., 1966, On the relationship of liver glucose-6-phosphatase to the proliferation of endoplasmic reticulum in phenobarbital induction, J. Cell Biol. 31: 243.

    Article  CAS  PubMed  Google Scholar 

  • Paul, J., Ross, W., And Montgomery, P., JR., 1971, Ulstrastructural nucleolar segregation and carcinogenicity among the 4-nitroquinoline-1-oxides, J. Natl. Cancer Inst. 47: 367.

    CAS  PubMed  Google Scholar 

  • Peers, F., Gilman, G., And Linsell, C., 1976, Dietary aflatoxine and human liver cancer. A study in Swaziland, Int. J. Cancer 17: 167.

    Article  CAS  PubMed  Google Scholar 

  • Pitot, H., 1964, Altered template stability: The molecular mark of malignancy? Perspect. Biol. Med. 8: 50.

    CAS  PubMed  Google Scholar 

  • Pokrovsky, A., Kravchenko, L., And Tutelyan, V., 1972, Comparative study of the effect of aflatoxin and some antitumour antibiotics on rat liver lysosomes in vivo and in vitro, Biochem. Pharmacol. 21: 2489.

    Article  CAS  Google Scholar 

  • Pong, R., And Wogan, G., 1970, Time course and dose—response characteristics of aflatoxin B1 effects on rat liver polymerase and ultrastructure, Cancer Res. 30: 294.

    CAS  PubMed  Google Scholar 

  • Porter, K., And Bruni, C., 1959, An electron microscope study of the early effects of 3’-Me-Dab on rat liver cells, Cancer Res. 19: 997.

    CAS  PubMed  Google Scholar 

  • Porter, K., Prescott, D., And Frye, J., 1973, Changes in surface morphology of Chinese hamster ovary cells during the cell cycle, J Cell Biol. 57: 815.

    Google Scholar 

  • Pour, P., Kruger, F., Chem, D., Althoff, J., Cardesa, A., And Mohr, U., 1974, Cancer of the pancreas induced in the Syrian golden hamster, Am. J. Pathol. 76: 349.

    CAS  PubMed  Google Scholar 

  • Pour, P., Kruger, F., Althoff, J., Cardesa, A., And Mohr, U., 1975, A new approach for induction of pancreatic neoplasms, Cancer Res. 35: 2259.

    Google Scholar 

  • Purchase, I., And Vorster, L., 1968, Aflatoxin in commercial milk samples, S. Afr. Med. J 42:219.

    Google Scholar 

  • Rao, M., And Reddy, J., 1978, Malignant tumors in rats fed lasiocarpine, Br. J. Cancer 37: 289.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rao, M., And Reddy, J., 1979, Transplantable acinar cell carcinoma of the rat pancreas. Morphologic and biochemical characterization, Am. J Pathol. 94: 333.

    CAS  Google Scholar 

  • Rao, M., Svoboda, D., And Reddy, J., 1974, The ultrastructural effects of aflatoxin B1 in the rat pancreas, Virchows Arch. B 17: 149.

    CAS  Google Scholar 

  • Reddy, J., And Qureshi, S., 1979, Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-a-p-chlorophenoxyisobutyrate (clofibrate) in rats, Br. J. Cancer 40: 476.

    Google Scholar 

  • Reddy, J., And Rao, M., 1977a, Malignant tumors in rats fed nafenopin, a hepatic peroxisome proliferator, J. Natl. Cancer Inst. 59: 1645.

    CAS  PubMed  Google Scholar 

  • Reddy, J., And Rao, M., 1977b, Transplantable pancreatic carcinoma of the rat, Science 198: 78.

    Article  CAS  PubMed  Google Scholar 

  • Reddy, J., And Rao, M., 1978, Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat, Br. J. Cancer 38:537.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Reddy, J., And Svoboda, D., 1968, The relationship of nucleolar segregation to ribonucleic acid synthesis following the administration of selected hepatocarcinogens, Lab. Invest. 19:132.

    Google Scholar 

  • Reddy, J., And Svoboda, D., 1972, Effect of lasiocarpine on aflatoxin B1 carcinogenicity in rat liver, Arch. Pathol. 93: 55.

    CAS  PubMed  Google Scholar 

  • Reddy, J., Chiga, M., And Svoboda, D., 1969, Initiation of the division cycle of rat hepatocytes following a single injection of thioacetamide, Lab. Invest. 20: 405.

    CAS  Google Scholar 

  • Reddy, J., Chiga, M., Bunyaratvej, S., And Svoboda, D., 1970, Microbodies in experimentally altered cells. Viii. Cpib-induced hepatic microbody proliferation in the absence of significant catalase synthesis, J. Cell Biol. 44: 226.

    Article  CAS  PubMed  Google Scholar 

  • Reddy, J., Svoboda, D., And Rao, M., 1974, Susceptibility of an inbred strain of guinea pigs to the induction of pancreatic adenocarcinoma by N-methyl-N-nitrosourea, J. Natl. Cancer Inst. 52: 991.

    CAS  PubMed  Google Scholar 

  • Reddy, J., Rao. M., And Jago, M., 1976a, Rapid development of hyperplastic nodules and cirrhosis in the liver of rats treated concurrently with thioacetamide and the pyrrolizidine alkaloid lasiocarpine, Int. J. Cancer 17: 621.

    CAS  Google Scholar 

  • Reddy, J., Rao, M., And Moody, D., 1976b, Hepatocellular carcinomas in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator, Cancer Res. 36: 1211.

    CAS  PubMed  Google Scholar 

  • Reddy, J., Svoboda, D., And Rao, M., 1976c, Induction of liver tumors by aflatoxin B1 in the tree shrew (Tupaia glis), a nonhuman primate, Cancer Res. 36: 151.

    CAS  PubMed  Google Scholar 

  • Reddy, J., Azarnoff, D., And Hignite, C., 1979a, Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens, Nature (London) 283: 397.

    Article  Google Scholar 

  • Reddy, J., Rao, M., Azarnoff, D., And Sell, S., 1979b, Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643), in rat and mouse liver, Cancer Res. 29: 152.

    Google Scholar 

  • Reddy, J., Rao, M., Warren, J., And Minnick, O., 1979c, Concanavalin A agglutinability and surface microvilli of dissociated normal and neoplastic pancreatic acinar cells of the rat, Exp. Cell Res. 120: 55.

    Article  CAS  PubMed  Google Scholar 

  • Reddy, J., Scarpelli, D., And Rao, M., 1979d, Experimental pancreatic carcinogenesis, in: Advances in Medical Oncology, Research and Education, Vol. 9 ( N. Thatcher, ed.), pp. 99–109, Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Report From The Committee OF Principal Investigators, 1978, A cooperative trial in the primary prevention of ischaemic heart disease using clofibrate, Br. Heart J. 40: 1069.

    Article  Google Scholar 

  • Rubin, E., Hutterer, F., And Lieber, C., 1968, Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes, Science 159: 1469.

    Article  CAS  PubMed  Google Scholar 

  • Ruebner, B., Michas, C., Kanarjama, R., And Bannasch, P., 1976, Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey, J. Natl. Cancer Inst. 57: 1261.

    Google Scholar 

  • Sachs, L., 1974, Regulation of membrane changes, differentiation, and malignancy in carcinogenesis, Harvey Lect. 68: 1.

    CAS  PubMed  Google Scholar 

  • Saffiotti, U., 1969, Experimental respiratory tract carcinogenesis, in: Progress in Experimental Tumor Research, Vol. 11 ( F. Homburger, ed.), pp. 302–333, Karger, Basel.

    Google Scholar 

  • Saffiotti, U., Cefis, F., And Kolb, L., 1968, A method for the experimental induction of bronchogenic carcinoma, Cancer Res. 28: 104.

    CAS  PubMed  Google Scholar 

  • Scott, P., And Kennedy, B., 1975, The analysis of spices and herbs for aflatoxins, Can. Inst. Food Sci. Technol. J. 8: 124.

    CAS  Google Scholar 

  • Scott, R., And Furcht, L., 1976, Membrane pathology of normal and malignant cells—A review, Human Pathol. 7: 519.

    Article  CAS  Google Scholar 

  • Shabad, L., Kolesnichenko, T., And Golub, N., 1975, The effect produced by some carcinogenic nitroso compounds on organ cultures from human embryonic lung and kidney tissues, Int. J. Cancer 16: 768.

    Google Scholar 

  • Shank, R., 1976, The role of aflatoxin in human disease, Adv. Chem. Ser. 149: 51.

    Article  CAS  Google Scholar 

  • Shinozuka, H., And Estes, L., 1977, Activation of intracisternal A particles in mouse liver by diethylnitrosamine, J. Natl. Cancer Inst. 58: 1163.

    CAS  PubMed  Google Scholar 

  • Shinozuka, H., And Farber, E., 1969, Reformation of nucleoli after ethionine-induced fragmentation in the absence of significant protein synthesis, J. Cell Biol. 41: 280.

    Article  CAS  PubMed  Google Scholar 

  • Shinozuka, H., Goldblatt, P., And Farber, E., 1968, The disorganization of hepatic cell nucleoli induced by ethionine and its reversal by adenine, J. Cell Biol. 36: 313.

    Article  CAS  PubMed  Google Scholar 

  • Shinozuka, H., Reid, I., Shull, K., Liang, H., And Farber, E., 1970, Dynamics of liver cell injury and repair. I. Spontaneous reformation of the nucleolus and polyribosomes in the presence of extensive cytoplasmic damage induced by ethionine, Lab. Invest 23: 253.

    CAS  PubMed  Google Scholar 

  • Shinozuka, H., Popp, J., And Konishi, Y., 1976, Ultrastructures of atypical acinar cell nodules in rat pancreas induced by 4-hydroxyaminoquinoline-1-oxide, Lab. Invest. 34: 501.

    CAS  PubMed  Google Scholar 

  • Simard, A., And Bernhard, W., 1966, Le phenomene de la segregation nucleolaire: specificite d’action de certains antimetabolites, Int. J. Cancer 1: 463.

    Article  CAS  PubMed  Google Scholar 

  • Simard, A., And Daoust, R., 1966, Dna synthesis and neoplastic transformation in rat liver parenchyma, Cancer Res. 26: 1665.

    CAS  PubMed  Google Scholar 

  • Slater, T., And Greenbaum, A., 1965, Changes in lysosomal enzymes in acute experimental liver injury, Biochem. J. 96: 484.

    CAS  PubMed  Google Scholar 

  • Smith, E., Nosanchuk, J., Schnitzer, B., And Swarm, R., 1968, Fatty inclusions and microcysts, Arch. Pathol. 85: 175.

    CAS  PubMed  Google Scholar 

  • Sporn, M., Dingman, C., Phelps, H., And Wogan, G., 1966, Aflatoxin B1: Binding to Dna in vitro and alteration of Rna metabolism in vivo, Science 151: 1539.

    CAS  Google Scholar 

  • Springer, E., Smith, H., And Hackett, A., 1979, Quantitative ultrastructure of the cytoplasmic organelles of human carcinoma and non-malignant epithelial cell lines, In Vitro 15: 228

    Google Scholar 

  • Steiner, J., Miyai, K., And Phillips, M., 1964, Electron microscopy of membrane-particle arrays in liver cells of ethionine-intoxicated rats, Am. J. Pathol. 44: 169.

    CAS  PubMed  Google Scholar 

  • Suzangar, M., Emami, A., And Barnett, R., 1977, Aflatoxin contamination of village milk in Isfahan, Iran, Trop. Sci. 18: 155.

    Google Scholar 

  • Svoboda, D., 1964, Fine structure of hepatomas induced in rats with p-dimethylaminoazobenzene, J. Natl. Cancer Inst. 33: 315.

    CAS  PubMed  Google Scholar 

  • Svoboda, D., And Azarnoff, D., 1966, Response of hepatic microbodies to a hypolipidemic agent, ethyl chlorophenoxyisobutyrate (Cpib), J. Cell Biol. 30: 442.

    Article  CAS  PubMed  Google Scholar 

  • Svoboda, D., And Azarnoff, D., 1979, Tumors in male rats fed ethyl chlorophenoxyisobutyrate, a hypolipidemic drug, Cancer Res. 39: 3419.

    CAS  PubMed  Google Scholar 

  • Svoboda, D., And Higginson, J., 1968, A comparison of ultrastructural changes in rat liver due to chemical carcinogens, Cancer Res. 28: 1703.

    CAS  PubMed  Google Scholar 

  • Svoboda, D., And Reddy, J., 1972, Malignant tumors in rats given lasiocarpine, Cancer Res. 32:908. Svoboda, D., And Soga, J., 1966, Early effects of pyrrolizidine alkaloids on the fine structure of rat liver cells, Am. J. Pathol. 48: 347.

    Google Scholar 

  • Svoboda, D., Grady, H., And Higginson, J., 1966, Aflatoxin B1 injury in rat and monkey liver, Am. J Pathol. 49: 1023.

    CAS  PubMed  Google Scholar 

  • Svoboda, D., Reddy, J., And Bunyaratvej, S., 197la, Hepatic megalocytosis in chronic lasiocarpine poisoning. Some functional studies, Am. J. Pathol. 65: 399.

    Google Scholar 

  • Svoboda, D., Reddy, J., And Liu, C., 1971 b, Multinucleate giant cells in livers of marmosets given aflatoxin B1, Arch. Pathol. 91: 452.

    Google Scholar 

  • Tatematsu, M., Cohen, S., Fukishima, S., Shinohara, Y., And Ito, N., 1977, Vascular changes during rat urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, Gann 68: 127.

    CAS  PubMed  Google Scholar 

  • Terao, K., And Nakano, M., 1974, Cholangiofibrosis induced by short-term feeding of 3’-methyl-4(dimethylamino)azobenzene: An electron microscopic observation, Gann 65: 249.

    CAS  PubMed  Google Scholar 

  • Tilak, T., 1975, Induction of cholangiocarcinoma following treatment of a rhesus monkey with aflatoxin, Food Cosmet. Toxicol. 13: 247.

    Article  CAS  PubMed  Google Scholar 

  • Timme, A., And Fowle, L., 1963, Effects of p-dimethylaminoazobenzene on the fine structure of rat liver cells, Nature (London) 200: 694.

    Article  CAS  Google Scholar 

  • Tuite, J., And Caldwell, R., 1971, Infection of corn seed with Helminthosporium maydis and other fungi in 1970, Plant Dis. Rep. 55: 387.

    Google Scholar 

  • Van Rensburg, S., Van Der Watt, J., Purchase, I., Coutinho, L., And Markham, R., 1974, Primary liver cancer rate and aflatoxin intake in a high cancer area, S. Afr. Med. J. 48: 2508A.

    CAS  PubMed  Google Scholar 

  • Vesselinovitch, S., Mihailovich, N., Wogan, G., Lombard, L., And Rao, K., 1972, Aflatoxin B, a hepatocarcinogen in the infant mouse, Cancer Res. 32: 2289.

    CAS  PubMed  Google Scholar 

  • Volman, H., 1978, A morphologic and morphometric study of the mitochondria in several hepatoma cell lines and in isolated hepatocytes, Virchows Arch. B 26: 249.

    CAS  Google Scholar 

  • Walborg, E., JR., Starling, J., Davis, E., Hixson, D., And Allison, J., 1979, Plasma membrane alterations during carcinogenesis, in: Carcinogens: Identification and Mechanisms of Action 31st

    Google Scholar 

  • Annual Symposium on Fundamental Cancer Research (A. C. Griffin and C. R. Shaw eds.), pp. 381–398, Raven Press, New York.

    Google Scholar 

  • Ward, J., Sontag, J., Weisburger, E., And Brown, C., 1975, Effect of life-time exposure to aflatoxin B1 in rats, J. Natl. Cancer Inst. 55: 107.

    CAS  PubMed  Google Scholar 

  • Warren, J., Simmon, V., And Reddy, J., 1980, Properties of hypolipidemic peroxisome proliferators in the lymphocyte [H]thymidine and Salmonella mutagenesis assays, Cancer Res. 40: 36.

    CAS  PubMed  Google Scholar 

  • Weibel, E., Staubli, W., Gnagi, R., And Hess, F., 1969, Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver, J. Cell Biol. 42: 68.

    Article  CAS  PubMed  Google Scholar 

  • Weinstein,.R., Merk, F., And Alroy, J., 1976, The structure and function of intercellular junctions in cancer, Adv. Cancer Res. 23: 23.

    Article  Google Scholar 

  • Williams, D., And Rabin, B., 1971, Disruption by carcinogens of the hormone dependent association of membranes with polysomes, Nature (London) 232: 102.

    Article  CAS  Google Scholar 

  • Williams, G., And Hultin, T., 1973, Ribosomes of mouse liver following administration of dimethylnitrosamine, Cancer Res. 33: 1796.

    CAS  PubMed  Google Scholar 

  • Willingham, M., And Pastan, I., 1975, Cyclic Amp modulates microvillus formation and agglutin-ability in transformed and normal mouse fibroblasts, Proc. Natl. Acad. Sci. Usa 72: 1263.

    Article  CAS  PubMed  Google Scholar 

  • Wilson, D., And Flowers, R., 1978, Unavoidable low level aflatoxin contamination of peanuts, J. Am. Oil Chem. Soc. 55: 111A.

    Article  CAS  Google Scholar 

  • Winslow, D., Roscoe, J., And Rowles, P., 1978, Changes in surface morphology associated with ethylnitrosourea-induced malignant transformation of cultured rat brain cells studied by electron microscopy, Br. J. Exp. Pathol. 59: 530.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wogan, G., And Paglialunga, S., 1974, Carcinogenicity of synthetic aflatoxin M1 in rats, Food Cosmet. Toxicol. 12: 381.

    Article  CAS  PubMed  Google Scholar 

  • Wogan, G., Paglialunga, S., And Newberne, P., 1974, Carcinogenic effects of low dietary levels of aflatoxin B1 in rats, Food Cosmet. Toxicol. 12: 681.

    Article  CAS  PubMed  Google Scholar 

  • Wong, J., And Hsieh, D., 1976, Mutagenicity of aflatoxine related to their metabolism and carcinogenic potential, Proc. Natl. Acad. Sci. Usa 73: 2241.

    Article  CAS  PubMed  Google Scholar 

  • Yasuzumi, G., Sugihara, R., Ito, N., Konishi, Y., And Hiasa, Y., 1970, Fine structure of nuclei as revealed by electron microscopy. Vii. Hyperplastic liver nodules in rat induced by 3’-methyl-4dimethylaminoazobenzene, 2-fluorenylacetamide and DL-ethionine, Exp. Cell Res. 63: 83.

    Article  CAS  PubMed  Google Scholar 

  • Zuretti, M., And Baccino, F., 1975, Biochemical and structural changes of rat liver lysosomes by ethionine, Exp. Mol. Pathol. 22: 271.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Oncology, University of Kansas College of Health Sciences, Kansas City, Kansas, USA

    Donald J. Svoboda

  2. Department of Pathology, Northwestern University Medical School, Chicago, Illinois, USA

    Janardan K. Reddy

Authors
  1. Donald J. Svoboda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Janardan K. Reddy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Anatomic and Research Pathology, M.D. Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston, Texas, USA

    Frederick F. Becker

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer Science+Business Media New York

About this chapter

Cite this chapter

Svoboda, D.J., Reddy, J.K. (1982). Some Effects of Carcinogens on Cell Organelles. In: Becker, F.F. (eds) Etiology: Chemical and Physical Carcinogenesis. Cancer, A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6598-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-6598-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6600-7

  • Online ISBN: 978-1-4615-6598-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation