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Clinical Trials using Monoclonal Antibodies

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Anticarcinogenesis and Radiation Protection

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Abstract

Early attempts at passive immunotherapy by administering natural antisera derived from recovered cancer patients to patients with active disease failed to result in significant antitumor responses. Many of the limitations of this serotherapy were remedied by the revolutionary innovation described by Kohler and Milstein (1) of monoclonal antibody production by means of hybridoma technology. Large quantities of homogeneous, highly specific antibody to a defined antigenic determinant became available for clinical trials. Most monoclonal antibodies (mAbs) used to date to treat cancer patients have been murine mAbs. Recently, clinical grade human mAbs have been generated in sufficient quantity to permit investigation.

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Authors and Affiliations

  1. Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, 21701, Frederick, Maryland, USA

    John W. Smith & Dan L. Longo

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  1. John W. Smith
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  2. Dan L. Longo
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Editors and Affiliations

  1. Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

    Peter A. Cerutti

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  3. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

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© 1987 Plenum Press, New York

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Smith, J.W., Longo, D.L. (1987). Clinical Trials using Monoclonal Antibodies. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_71

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  • DOI: https://doi.org/10.1007/978-1-4615-6462-1_71

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6464-5

  • Online ISBN: 978-1-4615-6462-1

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