Abstract
N-acetylcysteine (NAC), a precursor of intracellular cysteine and glutathione (GSH)) (1), is extensively used in the treatment of patients suffering from respiratory diseases. Moreover, this synthetic aminothiol has been shown to possess a variety of antitoxic properties in humans, animals and in vitro test systems (2).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
P. Moldéus, I. A. Cotgreave, and M. Berggren, Lung protection by a thiol-containing antioxidant: N-acetylcysteine, Respiration 50, 31–42 (1986).
F. M. Muggia, et al., N-acetylcysteune (NAC): a significant chemoprotective adjunct. Seminars in Oncology 10., 1–92 (1983).
D. M. Maron and B. N. Ames, Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173–215 (1983).
S. De Flora, P. Zanacchi, A. Camoirano, C. Bennicelli, and G. Badolati, Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test. Mutat. Res. 133, 161–198 (1984).
D. E. Levin, M. Hollstein, M. F. Christman, E. A. Schwiers, and B. N. Ames, A new Salmonella tester strain (TA102) with A-T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci. USA 79, 7445–7449 (1982).
H. Joenje, Introduction: oxygen metabolism, DNA repair, and the origin of spontaneous genetic instability. In Antimutagenesis and Anticarcinogenesis Mechanisms, 1986 (D. M. Shankel, P. E. Hartman, T. Kada and A. Hollaender, Eds.) pp. 339–341. Plenum Press, New York and London.
S. De Flora, C. Bennicelli, P. Zanacchi, A. Camoirano, A. Morelli, and A. De Flora, In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens. Carcinogenesis 5, 505–510 (1984).
M. Wilpart, P. Mainguet, D. Geeroms, and M. Roberfroid, Desmutagenic effects of N-acetylcysteine on direct and indirect mutagens. Mutat. Res. 142, 169–177 (1985).
S. De Flora, et al., manuscripts in preparation.
S. De Flora, C. Bennicelli, D. Serra, A. Izzotti, and C. F. Cesarone, Role of glutathione and N-acetylcysteine as inhibitors of mutagenesis and carcinogenesis. In Absorption and Utilization of Amino Acids (M. Friedman, Ed.). CRC Press, Inc., Boca Raton, FL (in press).
S. De Flora, Detoxification of genotoxic compounds as a threshold mechanism limiting their carcinogenicity. Toxicol. Pathol. 12, 337–343 (1984).
S. De Flora, C. Bennicelli, A. Camoirano, and P. Zanacchi, Genotoxicity of nitrosated ranitidine. Carcinogenesis 4, 255–260 (1983).
S. De Flora, A. Camoirano, C. Basso, M. Astengo, P. Zanacchi, and C. Bennicelli, Bacterial genotoxicity of nitrosated famotidine. Mutagenesis 1, 125–130 (1986).
S. De Flora, C. Bennicelli, A. Camoirano, D. Serra, M. Romano, G. A. Rossi, A. Morelli, and A. De Flora, In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 6, 1735–1745 (1985).
S. De Flora, M. Romano, C. Basso, M. Bagnasco, C. F. Cesarone, G. A. Rossi, and A. Morelli, Modulation of detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or Aroclor. Anticancer Res. 6, 1009–1012 (1986).
S. De Flora, M. Astengo, D. Serra, and C. Bennicelli, Inhibition of urethan-induced lung tumors in mice by dietary N-acetyl-cysteine. Cancer Lett. 32, 235–241 (1986).
C. F. Cesarone, L. Scarabelli, M. Orunesu, M. Bagnasco, A. Izzotti, and S. De Flora, Protective effects of thiols on carcinogenesis induced in rats by 2-acetylaminof luorene. This volume.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
De Flora, S. et al. (1987). Inhibition of Mutagenesis and Carcinogenesis by N-Acetylcysteine. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_56
Download citation
DOI: https://doi.org/10.1007/978-1-4615-6462-1_56
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-6464-5
Online ISBN: 978-1-4615-6462-1
eBook Packages: Springer Book Archive