Skip to main content

Inhibition of Mutagenesis and Carcinogenesis by N-Acetylcysteine

  • Chapter

Abstract

N-acetylcysteine (NAC), a precursor of intracellular cysteine and glutathione (GSH)) (1), is extensively used in the treatment of patients suffering from respiratory diseases. Moreover, this synthetic aminothiol has been shown to possess a variety of antitoxic properties in humans, animals and in vitro test systems (2).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. P. Moldéus, I. A. Cotgreave, and M. Berggren, Lung protection by a thiol-containing antioxidant: N-acetylcysteine, Respiration 50, 31–42 (1986).

    PubMed  Google Scholar 

  2. F. M. Muggia, et al., N-acetylcysteune (NAC): a significant chemoprotective adjunct. Seminars in Oncology 10., 1–92 (1983).

    PubMed  CAS  Google Scholar 

  3. D. M. Maron and B. N. Ames, Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173–215 (1983).

    PubMed  CAS  Google Scholar 

  4. S. De Flora, P. Zanacchi, A. Camoirano, C. Bennicelli, and G. Badolati, Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test. Mutat. Res. 133, 161–198 (1984).

    PubMed  Google Scholar 

  5. D. E. Levin, M. Hollstein, M. F. Christman, E. A. Schwiers, and B. N. Ames, A new Salmonella tester strain (TA102) with A-T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci. USA 79, 7445–7449 (1982).

    Article  PubMed  CAS  Google Scholar 

  6. H. Joenje, Introduction: oxygen metabolism, DNA repair, and the origin of spontaneous genetic instability. In Antimutagenesis and Anticarcinogenesis Mechanisms, 1986 (D. M. Shankel, P. E. Hartman, T. Kada and A. Hollaender, Eds.) pp. 339–341. Plenum Press, New York and London.

    Google Scholar 

  7. S. De Flora, C. Bennicelli, P. Zanacchi, A. Camoirano, A. Morelli, and A. De Flora, In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens. Carcinogenesis 5, 505–510 (1984).

    Article  PubMed  Google Scholar 

  8. M. Wilpart, P. Mainguet, D. Geeroms, and M. Roberfroid, Desmutagenic effects of N-acetylcysteine on direct and indirect mutagens. Mutat. Res. 142, 169–177 (1985).

    Article  PubMed  CAS  Google Scholar 

  9. S. De Flora, et al., manuscripts in preparation.

    Google Scholar 

  10. S. De Flora, C. Bennicelli, D. Serra, A. Izzotti, and C. F. Cesarone, Role of glutathione and N-acetylcysteine as inhibitors of mutagenesis and carcinogenesis. In Absorption and Utilization of Amino Acids (M. Friedman, Ed.). CRC Press, Inc., Boca Raton, FL (in press).

    Google Scholar 

  11. S. De Flora, Detoxification of genotoxic compounds as a threshold mechanism limiting their carcinogenicity. Toxicol. Pathol. 12, 337–343 (1984).

    Article  PubMed  Google Scholar 

  12. S. De Flora, C. Bennicelli, A. Camoirano, and P. Zanacchi, Genotoxicity of nitrosated ranitidine. Carcinogenesis 4, 255–260 (1983).

    Article  PubMed  Google Scholar 

  13. S. De Flora, A. Camoirano, C. Basso, M. Astengo, P. Zanacchi, and C. Bennicelli, Bacterial genotoxicity of nitrosated famotidine. Mutagenesis 1, 125–130 (1986).

    Article  PubMed  Google Scholar 

  14. S. De Flora, C. Bennicelli, A. Camoirano, D. Serra, M. Romano, G. A. Rossi, A. Morelli, and A. De Flora, In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 6, 1735–1745 (1985).

    Article  PubMed  Google Scholar 

  15. S. De Flora, M. Romano, C. Basso, M. Bagnasco, C. F. Cesarone, G. A. Rossi, and A. Morelli, Modulation of detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or Aroclor. Anticancer Res. 6, 1009–1012 (1986).

    PubMed  Google Scholar 

  16. S. De Flora, M. Astengo, D. Serra, and C. Bennicelli, Inhibition of urethan-induced lung tumors in mice by dietary N-acetyl-cysteine. Cancer Lett. 32, 235–241 (1986).

    Article  PubMed  Google Scholar 

  17. C. F. Cesarone, L. Scarabelli, M. Orunesu, M. Bagnasco, A. Izzotti, and S. De Flora, Protective effects of thiols on carcinogenesis induced in rats by 2-acetylaminof luorene. This volume.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

De Flora, S. et al. (1987). Inhibition of Mutagenesis and Carcinogenesis by N-Acetylcysteine. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_56

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-6462-1_56

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6464-5

  • Online ISBN: 978-1-4615-6462-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics