Abstract
Repeated exposure of mice to UVB (280 to 320 nm) radiation results in the development of a state of tumor-specific suppression that renders the host Incapable of mounting an effective immunological rejection response to antigenic determinants expressed by UV-induced skin tumor cells (1,2). In this system, normal mice can reject transplanted UV-induced tumor cells, whereas UV-treated mice cannot. The objective of this research was to determine if UVB irradiation influences mouse skin tumorigcnesis induced by an initiation-promotion protocol.
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References
M.L. Kripke, The Immunology of skin cancer. In Immunology and Cancer, The University of Texas M.D. Anderson Symposium on Fundamental Cancer Research, Vol. 38, 1986 (M.L. Kripke and P. Frost, Eds.) pp. 113–120, University of Texas Press, Austin, Texas.
C.W. Spellman and R.A. Daynes, Ultraviolet light induced murine suppressor lymphocytes dictate specificity of anti-ultraviolet tumor immune responses. Cell. Immunol. 38, 25–34 (1978).
W.J. Conover, Practical Nonparametric Statistics, 1980, John Wiley and Sons, New York.
N. Breslow, A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship. Biometrlka 57, 579–594 (1970).
L.K. Roberts and R.A. Daynes, Modification of the immunogenic properties of chemically Induced tumors arising in hosts treated concomitantly with ultraviolet light. J. Immunol. 125, 438–447 (1980).
P.T. Strickland, D. Creasla and M.L. Kripke, Enhancement of two-stage skin carcinogenesis by exposure of distant skin to UV radiation. J. Natl. Cancer Inst. 74, 1129–1134 (1985).
M.S. Fisher and M.L. Kripke, Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-Irradiated mice. Science 216, 1133–1134 (1982).
M.L. Kripke, Latency, histology, and antigenicity of ttamors induced by ultraviolet light in three inbred mouse strains. Cancer Res. 37, 1395–1400 (1977).
L.K. Roberts and R.A. Daynes, Modifications of the immunogenic properties of chemically induced tumors arising in hosts treated concomitantly with ultraviolet light. J. Immunol. 438–444 (1980).
A.W. Wood, R.L. Chang, M.T. Huang, M. Uskokovlc and A.H. Conney, 1α,25-dihydroxyvitamin D3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin. Biochem. Biophys. Res. Comm. 116, 605–611 (1983).
A.W. Wood, R.L. Chang, M.T. Huang, E. Baggiolini, J.J. Partridge, M. Uskokovlc and A.H. Conney, Stimulatory effect of 1α,25-dihydroxjrvitamin D3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene. Biochem. Biophys. Res. Comm. 130, 924–931 (1985).
K. Chida, H. Hashiba, M. Fukushima, T. Suda and T. Kurokl, Inhibition of tumor promotion in mouse skin by 1α,25-dihydroxyvitamin D3. Cancer Res. 45, 5426–5430 (1985).
A.K. Verma, E.A. Conrad and R.K. Boutwell, Differential effects of retinóle acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen. Cancer Res. 42, 3519–3525 (1982).
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© 1987 Plenum Press, New York
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Gensler, H.L. (1987). UVB Prevention of Mouse Skin Tumor Induction by the Initiation-Promotion Protocol. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_32
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DOI: https://doi.org/10.1007/978-1-4615-6462-1_32
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