Abstract
Although the molecular mechanisms involved in carcinogenesis are poorly understood at this time, intermediary events in the development of cancer have been described through the selective actions of discrete chemical agents (1). These processes have been studied in various model systems and have been termed initiation, promotion and progression (2). Initiation appears to involve the modification of cellular DNA, resulting in genotypically altered cells, while promotion encompasses a continuum of events allowing for the selection and clonal expansion of the initiated cells (3). Finally, progression completes the conversion of pre-malignant cells to malignant cells. Substantial evidence supports the involvement of free radical species, especially those derived from molecular oxygen, in multiple aspects of these processes (4).
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References
R.M. Hicks, Pathological and biochemical aspects of tumour promotion. Carcinogenesis 4, 1209–1214 (1983).
S.H. Yuspa, T. Ben, H. Hennings, and U. Lichti, Divergent responses in epidermal basal cells exposed to the tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA). Cancer Res. 42. 2344–2349 (1982).
T.J. Slaga, (Ed.), Mechanisms of Tumor Promotion, Vol. 1–4, CRC Press, Boca Raton, 1984.
T.W. Kensler and B.G. Taffe, Free radicals in tumor promotion. Adv. Free Radical Biol. Med. 2, 347–387 (1986).
J.F. O’Connell, A.J.P. Klein-Szanto, D.M. DiGiovanni, J.W. Fries, and T.J. Slaga, Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res. 46, 2863–2865 (1986).
P. Watts, Peroxides, genes and cancer. Food Chem. Toxicol. 23, 957–960 (1985).
T.J. Slaga, A.J.P. Klein-Szanto, L.L. Triplett, L.P. Yotti, and J.E. Trosko, Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science 213, 1023–1025 (1981).
W.A. Pryor, Free Radicals. McGraw-Hill Book Company, New York, 1966.
S.H. Yuspa, P. Hawley-Nelson, J.R. Stanley, and H. Hennings, Epidermal cell culture. Transplant. Proc. 12S, 114–122 (1976).
C.H. Kennedy, W.A. Pryor, G.W. Winston, and D.F. Church, Hydroperoxide-induced radical formation in liver mitochondria. Biochem. Biophys Res. Commun. 141, 1123–1129 (1986).
B. Kalyanaraman, C. Mottley, and R.P. Mason, A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems. J. Biol. Chem. 258, 3855-3858 (1983).
W.A. Pryor, D.L. Fuller, and J.P. Stanley, Reactivity patterns of the methyl radical. J. Am. Chem. Soc. 94, 1632–1638 (1972).
D.E. Levin, M. Hollstein, M.F. Christman, E.A. Schwiers, and B.N. Ames, A new Salmonella tester strain (TA 102) with A-T base pairs at the site of mutation detects oxidative mutagens. Proc. Natl. Acad. Sci. U.S.A. 79, 7445–7449 (1982).
H.L. Gensler, and G.T. Bowden, Evidence suggesting a dissociation of DNA strand scissions and late-stage promotion of tumor cell phenotype. Carcinogenesis 4, 1507–1511 (1983).
T. Ochi, and P.A. Cerutti, Clastogenic action of hydroperoxy-5,8,11,13-eicosatetraenoic acids on the mouse embryo fibroblasts C3H/10T2. Proc. Natl. Acad. Sci. U.S.A. 84, 990–994 (1987).
H. Sies, P. Graf, and J.M. Estrela, Hepatic calcium efflux during cytochrome P-450 dependent drug oxidations at the endoplasmic reticultun in intact liver. Proc. Natl. Acad. Sci. U.S.A. 78, 3358–3362 (1981).
O. Augusto, L.R. Du Plessis, and C.L.V. Weingrill, Spin trapping of methyl radical in the oxidative metabolism of 1,2-dimethylhydrazine. Biochem. Biophys. Res. Commun. 126, 853–858 (1985).
L.C. Boffa, R.J. Gruss, and V.G. Allfrey, Aberrent and nonrandom methylation of chromosomal DNA-binding-proteins of colonic epithelial cells by 1,2-dimethylhydrazine. Cancer Res. 42. 382–388 (1982).
S. Ichimura, K. Mita, and M. Zama, Essential role of arginine residues in the folding of deoxyribonucleic acid into nucleosome cores. Biochemistry 21. 5329–5334 (1982).
W.K. Paik, P. Dimaria, S. Kim, P.N. Magee, and P.D. Lotlikar, Alkylation of protein by methyl methane sulfonate and 1-methyl-1-nitrosourea in vitro. Cancer Lett. 23, 9–17 (1984).
C. Turberville and V.M. Craddock, Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo. Biochem. J. 124, 725–739 (1971).
R.L. Willson, Organic peroxy free radicals as ultimate agents in oxygen toxicity. In: Oxidative Stress (H. Sies, Ed.) pp. 41–72. Academic Press, London, 1985.
M.E. Hemler, H.W. Cook, and W.E.M. Lands, Prostaglandin biosynthesis can be triggered by lipid peroxides. Arch. Biochem. Biophys. 193, 340–345 (1979).
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Taffe, B.G., Kensler, T.W., Takahashi, N., Mason, R.P. (1987). Activation of Organic Hydroperoxide Tumor Promoters to Free Radicals in Target Cells. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_30
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DOI: https://doi.org/10.1007/978-1-4615-6462-1_30
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