Abstract
Mouse hepatitis virus (MHV-4, JHM) is a neurotropic coronavirus which causes a spectrum of disease ranging from fatal encephalomyelitis to demyelination in susceptible murine hosts (1). Both direct infection of oligodendrocytes and immune-mediated events have been reported to play a role in the pathologic events in the central nervous system (CNS) following MHV-4 infection (2–5). The identification of CD8+ T-cells, NK cells, B-cells and PMN in the CNS of MHV-JHM infected mice suggests that immune mechanisms may be playing a role in the virus-induced disease process (3–9).
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Keywords
- Endothelial Cell
- Cytokine Induction
- Mouse Hepatitis Virus
- Cerebral Endothelial Cell
- Lymphocytic Choriomeningitis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Bailey, O.T., Pappenheimer, A.M., and Cheever, F.S., 1949, J. Exp. Med., 90:195.
Knobler, R.L., Haspel, M.V., and Oldstone, M.B.A., 1981, J. Exp. Med., 153:832.
Knobler, R.L., Tunison, L.A., Lampert, P.W., and Oldstone, M.B.A., 1982, Am. J. Pathol., 109:157.
Wang, F-I., Stohlman, S.A., and Fleming, J.O., 1991, J. Neuroimmunol., 30:31.
Williamson, J.S.P., Sykes, K.C., and Stohlman, S.A., 1991, J. Neuroimmunol., 32:199.
Stohlman, S.A., Brayton, P.R., Harmon, R.C., Stevenson, R.G., Ganges, R.G., and Matsushima, G.K., 1983, Int. J. Cancer., 31:309.
Welsh, R.M., Haspel, M.V., Parker, D.C., and Holmes, K.V., 1986, J. Immunol., 136:1454.
Natuck, R.J., and Welsh, R.M., 1987, J. Immunol., 138:877.
Zimprich, F., Winter, J., Wege, H., and Lassmann, H., 1991, Neuropathol. Applied. Neurobiol., 17:469.
Frei, K., Leist, T.P., Meager, P., Gallo, P., Leppert, D., Zinkernagel, R.M. and Fontana, A., 1988, J. Exp. Med., 168:449.
Frei, K., Malipiero, U.V., Leist, T.P., Zinkernagel, R.M., Schwab, M.E., and Fontana, A., 1989, Eur. J. Immunol., 19:689.
Jirik, F.R., Podor, T.J., Hirano, T., Kishimoto, T., Loskutoff, D.J., Carson, D.A., and Lotz, M., 1989, J. Immunol., 142:144
Lieberman, A.P., Pitha, P.M., Shin, H.S., and Shin, M.L., 1989, PNAS., 86:6348.
Shalaby, M.R., Waage, A., and Esperik, T., 1989, Cell. Immunol., 121:372.
Sironi, M., Brevario, F., Prosperio, P., Biondi, A., Vecchi, A., Van Damme, J., Dejana, E., and Mantovani, A.,1989, J. Immunol., 142:549.
Beneveniste, E.N., Sparacio, S.M., Norris, J.G., Grenett, H.E., and Fuller, G.M., 1990, J. Neuroimmunol., 30:201.
Joseph, J., Knobler, R.L., Lublin, F.D., and Hart, M.N., 1989, J. Neuroimmunol., 22:241.
Joseph, J., Knobler, R.L., Lublin, F.D., and Hart, M.N., 1990, Adv. Exp. Med. Biol., 276:579.
Joseph, J., Knobler, R.L., Lublin, F.D., and Hart, M.N., 1991, J. Neuroimmunol., 33:181.
Houssiau, F.A., Bukasa, K., Sindic, C.J.M., Van Damme, J., and Van Snick, J., 1988, Clin. Exp. Immunol., 71:320.
Breen, E.C., Rezai, A.R., Nakajima, K., Beall, G.N., Mitsuyasu, R.T., Hirano, T., Kishimoto, T., and Martinez-Maza, O., 1990, J. Immunol., 144:480.
Nishimoto, N., Yoshizaki, K., Eiraku, N., Machigashira, K., Tagoh, H., Ogata, A., Kuritani, T., Osame, M., and Kishimoto, T., 1990, J. Neurol. Sci.,97:183.
Cernetti, C., Steinman, R.M., and Granelli-Piperno, A., 1988, PNAS., 85:1605.
Takai, Y., Wong, G.G., Clark, S.C., Burakoff, S.J., and Hermann, S.H., 1988, J. Immunol., 140:508.
Borish, L., Rosenbaum, R., Albury, L., and Clark, S., 1989, Cell. Immunol., 121:280.
Le, J., and Vilcek, J.,1989, Lab. Invest., 61:588.
DeBault, L.E., Henriquez, E., Hart, M.N., and Cancilla, P.A., 1981, In Vitro., 17:480.
Knobler, R.L., Cole, R., de Vellis, J., Lewicki, H., Buchmeier, M., and Oldstone, M.B.A., 1987, In Coronaviruses., M.M.C. Lai and S.A. Stohlman, eds. Plenum, New York, p. 231.
McCarthy, K.D., and deVellis, J., 1980, J. Cell. Biol., 85:890.
Jayaraman, S., Martin, C.A., and Dorf, M.E., 1990, J. Immunol., 144:942.
Maniatis, T., Fritsch, E.F. and Sambrook, J. 1982., Molecular Cloning, a Laboratory Manual.
Williams, R.K., Jiang, G.S., Snyder, S.W., Frana, M.F., and Holmes, K.V., 1990, J. Virol., 64:3817.
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© 1994 Springer Science+Business Media New York
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Joseph, J., Grun, J.L., Lublin, F.D., Knobler, R.L. (1994). Cytokine Induction in Vitro in Mouse Brain Endothelial Cells and Astrocytes by Exposure to Mouse Hepatitis Virus (MHV-4, JHM). In: Laude, H., Vautherot, JF. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 342. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2996-5_70
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DOI: https://doi.org/10.1007/978-1-4615-2996-5_70
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