Abstract
Mouse hepatitis virus (MHV) RNA synthesis, including replication of viral genome and transcription of subgenomic mRNAs, has been shown to be regulated by several viral RNA elements, including 5’-untranslated region (5’-UTR), cis- and trans-acting leader RNA, intergenic (IG) sequence, and 3’-UTR (Lai and Cavanagh 1997). Biochemical evidence suggests that these regulatory sequences likely interact with each other either directly or indirectly, probably through protein-RNA and protein-protein interactions involving both viral and cellular proteins (Zhang and Lai 1995). Several cellular proteins have been found to bind these regulatory sequences by UV-crosslinking experiments (Furuya and Lai 1993, Huang and Lai 1999); three of these proteins have been identified to be heterogeneous nuclear ribonucleoprotein Al (hnRNP A1) (Li et al 1997), polypyrimidine-tractbinding protein (PTB) (Huang and Lai 1999, Li et al 1999), and poly(A)-binding protein (PABP) (Spagnolo and Hogue 2000).
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Shi, S.T., Huang, P., Li, HP., Lai, M.M.C. (2001). Regulation of Mouse Hepatitis Virus RNA synthesis by Heterogeneous Nuclear Ribonucleoprotein Al. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_63
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DOI: https://doi.org/10.1007/978-1-4615-1325-4_63
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