Abstract
CD8+ T cells control infection by the neurotropic JHM strain of mouse hepatitis virus (JHMV) by eliminating infectious virus and reducing CNS pathology (Stohlman et al. 1995). Virus-specific CTL in BALB/c mice (H-2d) respond almost exclusively to a single immunodominant epitope in the nucleocapsid (N) protein (Bergmann et al. 1993). During acute JHMV infection, CD8+ T cells account for up to 40% of CNS mononuclear cells (MNC) (Bergmann et al. 1999). Following viral clearance, virus specific CD8+ T cells remain in CNS for several weeks (Bergmann et al. 1999).
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Marten, N.W., Hohman, M., Stohlman, S.A., Atkinson, R.D., Hinton, D.R., Bergmann, C.C. (2001). Acute CNS Infection is Insufficient to Mediate Chronic T Cell Retention. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_52
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DOI: https://doi.org/10.1007/978-1-4615-1325-4_52
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