Abstract
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with the autoimmune component. It is characterised by discrete, multifocus lesions of myelin degradation. All phenotypes of lymphocytes and activated macrophages are represented in the inflammatory infiltrates. Myelin basic protein reactive T cells, macrophages and microglia produce a wide range of factors, wich may influence oligodendrocyte function during the demyelinating process. The complex of pro inflammatory cytokines is, probably, the major factor of demyelination (1,3,7).
Chapter PDF
Similar content being viewed by others
Keywords
- Multiple Sclerosis
- Peripheral Blood Mononuclear Cell
- Multiple Sclerosis Patient
- Myelin Basic Protein
- Cytokine mRNA Expression
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Brosnan C. F., Raine C. S., 1996, Mechanisms of immune injury in multiple sclerosis. Brain Pathol. 6 (3): 243–257.
Gaidul K. V., Chernukhin I. V., Khaldoianidi S. K., Svinarchuk F. P., e.a. 1995, Functional activity of T-, B-lymphocytes and macrophages during suppression of expression of the env gene from an endogenous retrovirus genome. Mol. Biol., Moscow, 29 (3):612–618.
Hermans G., Stinissen P., Hauben L., Van den Berg-Loonen E., e.a. 1997. Cytokine profile of myelin basic protein - reactive T cells in multiple sclerpsis and healthy individuals. Ann. Neurol. 42: 18–27.
Krieg A. M., Steinberg A.D. 1990, Retroviruses and autoimmunity. J. Autoimmunity 3: 137–166.
Kreig A.M., Steinberg A.D. 1992, Endogenous retroviruses: potential etiologic agents in autoimmunity. FASEB J. 6:2537–2544.
Larsson E., Kato N., Cohen M. 1989, Human endogenous proviruses. Current topics in microbiology and immunology, Volume 148. Berlin: Springer - Verlag, 115–132.
Ledeen R.W., Chakraborty G. 1998, Neurochemical Researh, Volume 23 (3): 277–289.
Maniatis T., Fritsch E. R., Sambrook J. 1982, Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, New York.
Nielsen L., Larsen A. M., Munk M., Vestergaard B. F. 1997, Human herpesvirus-6 immunoglobulin G antibodies in patients with multiple sclerosis. Acta Neurol. Scand. Suppl. 169: 76–78.
Rasmussen H.B., Clausen J. 1997, Possible involvement of endogenous retroviruses in the development of autoimmune disorders, especially multiple sclerosis. Acta Neurol. Scand. Suppl. 169: 32–37.
Rasmussen H. B., Geny C., Deforges L., Perron H., e. a.1997, Expression of endogenous retroviruses in blood mononucleal cells and brain tissue from multiple sclerosis patients. Acta Neurol. Scand., Suppl. 168:38–44.
Rubin L.A., Siminovitch K.A., Shi M.N., Cohen M. 1991, A novel retroviral gene assotiation with rheumatoid arthritis. Arthritis Rheum. Suppl. 34:60.
Simon J., Neubert W. J. 1996, The pathogenesis of multiple sclerosis: reconsideration of the role of viral agents and defence mechanisms. Med. Hypotheses 46 (6): 537–543.
Stoye J., Coffin J. 1985, Endogenous retroviruses. In: Weiss R., Teich N., Varmus H., Coffin J., ed. RNA tumor viruses, Volume 2. Cold Spring Harbor
Talbot P. J., Paquette J.S., Ciurli C. e. a. 1996, Myelin basic protein and human coronavirus 229E cross - reactive T cells in multiple sclerosis. Ann. Neurol. 39 (2): 233–240.
Turbeville M. A., Rhodes J. C., Hyams D. M., e.a. 1996, Expression of a putative immunosuppressive protein in human tumors and tissues. Pathobiology 64 (5): 233–238.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Goldina, I.A. et al. (2001). Proinflammatory Cytokines mRNA Expression in Dependence of Suppressive Epitope of Retroviral Transmembrane p15E Peptide Activation at Multiple Sclerosis Patients. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_92
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0667-6_92
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5185-6
Online ISBN: 978-1-4615-0667-6
eBook Packages: Springer Book Archive