Abstract
Patients undergoing bone marrow transplantation for hematologic disorders are severely immunocompromised by the intensive chemotherapy and total body irradiation used in preparation for the transplant. Interstitial pneumonia occurs as a complication in approximately 40% of all bone marrow transplant recipients and is fatal in 70% of cases (1–3). Cytomegalovirus (CMV) is the most common pathogen associated with the interstitial pneumonia and can be identified in 50–70% of cases.
Supported by grants CA-23175, from the National Cancer Institute and by grant RR-865 from the Public Health Service. Dr. Champlin is a recipient of a New Investigator Research Award, National Institute of Arthritis, Diabetes and Kidney Disease. Dr. Gale is the Meyerhoff Visiting Scientist of the Weizman Institute of Science.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Winston DJ, Bryson YJ, Ho WG, Territo MD, Golde DW, Gale RP. Interstitial pneumonia and cytomegalovirus infection after bone marrow transplantation. In: Gale RP, Fox GE, eds. Biology of bone marrow transplantation, New York, Academic Press, 1980: 83–95.
Winston DJ, Ho WG, Champlin RE, Gale RP. Treatment and prevention of interstitial pneumonia associated with bone marrow transplantation. In: Gale RP, Fox GE, eds. Recent advances in bone marrow transplantation. UCLA Symposia on Molecular and Cellular Biology, Vol. 7, New York: Alan R. Liss Inc. (in press).
Meyers JD, Flournoy N, Thomas ED. Nonbacterial pneumonia after allogeneic marrow transplantation - A review of ten years’ experience. Rev Infect Dis 1982; 4: 1119–32.
Kraemer KG, Neiman PE, Reeves WC, Thomas ED. Prophylactic adenine arabinoside following marrow transplantation. Transplant Proc 1978; 10: 237–40.
Meyers JD, McGuffin RW, Neiman PE, Singer JW, Thomas ED. Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. J Infect Dis 1980; 141: 555–62.
Saral R, Burns WH, Laskin OL, Santos GW, Lietman PS. Acyclovir prophylaxis of herpes-simplex-virus infections: A randomized double blind controlled trial in bone marrow transplant recipients. N Engl J Med 1981; 305: 63–7.
Meyers JD, McGuffin RW, Bryson YJ, Cantell K, Thomas ED. Treatment of cytomegalovirus pneumonia after marrow transplant with combined vidarabine and human leukocyte interferon. J Infect Dis 1982; 146: 80–4.
Wade JC, Hintz M, McGuffin RW, Springmeyer SC, Connor JD, Meyers JD. Treatment of cytomegalovirus pneumonia with high dose acyclovir. Am J Med (Suppl) 1982; 73: 249–56.
Winston DJ, Pollard RB, Ho WG, et al. Cytomegalovirus immune plasma in bone marrow transplant recipients. Am Intern Med 1982; 97: 11–8.
Winston DJ, Ho WG, Ramussen LE, et al. Use of intravenous immune globulin in patients receiving bone marrow transplants. J Clin Immunol (Suppl) 1982; 2: 425–75.
Gale RP. Current status of bone marrow transplantation in acute leukemia. Transplant Proc 1979; 9: 1920–3.
Gale RP, Ho WG, Feig SA, Champlin RE. Prevention of graft rejection following bone marrow transplantation. Blood 1981; 57: 9–12.
Feig SA, Champlin R, Arenson E, et al. Improved survival following bone marrow transplantation in aplastic anemia. Br J Haematol 1983; 54: 509–17.
Casey HL. Adaptation of laboratory branch complement-fixation method to micro technique. Public monograph no 74 Washington DC: Government Printing Office, 1965.
Howell CL, Miller MJ, Martin WJ. Comparison of rates of virus isolation from leukocyte populations separated from blood by conventional and ficoll-paque/macrodex methods. J Clin Microbiol 1979; 10: 533–7.
Meyers JD, Leszczynski J, Zaia JA, et al. Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation. Ann Intern Med 1983; 98: 442–6.
O’Reilly RJ, Reich L, Gold J, et al. A randomized trial of intravenous hyperimmune globulin for the prevention of cytomegalovirus (CMV) infections following marrow transplantation - Preliminary results. Transplant Proc 1983; 15: 1405–11.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Ho, W.G., Winston, D.J., Champlin, R.E., Gale, R.P. (1984). CMV Infection and its Prevention with Specific Immunoglobulins. In: Smit Sibinga, C.T., Das, P.C., Opelz, G. (eds) Transplantation and Blood Transfusion. Developments in Hematology and Immunology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3840-6_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3840-6_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3842-0
Online ISBN: 978-1-4613-3840-6
eBook Packages: Springer Book Archive