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Comparison of Calcium Blocking Activities of Adenosine Potentiating Compounds With Calcium Blocking Drugs in Isolated Smooth Muscle and Atria

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 39))

Abstract

It is widely recognized that calcium ions play a vital role in many cell processes and in a variety of muscle tissues (particularly in the function of cardiac tissue and vascular smooth muscle). Since Fleckenstein et al. (1) in 1969 reported the inhibition of myocardial contractility by calcium antagonists, extensive investigation of the pharmacologic properties and the therapeutic applications of these drugs have been carried out in the last decade (2–11). These drugs are also known as “calcium antagonists”, “slow- channel inhibitors”, “calcium channel blockers” or “calcium entry blockers”.

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References

  1. Fleckenstein A, Tritthart B, Fleckenstein B, Herbst A, Grun G: Selective inhibition of myocardial contractility by competitive calcium antagonists (iproveratril, D600, prenylamine). Naunyn-Schmiedeberg’s Arch. Pharmacol., (264): 22 7–228, 1969.

    Google Scholar 

  2. Fleckenstein A: Specific pharmacology of calcium in myocardium, cardiac pacemakers and vascular smooth muscle. Annu. Rev. Pharmacol. Toxicol. (17): 149–166, 1977.

    Article  CAS  PubMed  Google Scholar 

  3. Bailey JC, Elharrar V, Zipes, DP: Slow-channel depolarization: Mechanism and control of arrhythmias. Annu. Rev. Med. 29:417–426, 1978.

    Article  CAS  PubMed  Google Scholar 

  4. Luchi RJ, Chahine RA, Raizner AE Coronary artery spasm. Ann. Int. Med. (91): 5441–449, 1979.

    Article  Google Scholar 

  5. Rahwan RG, Piascik MF, Witiak DT: The role of calcium antagonism in the therapeutic action of drugs. Can. J. Physiol. Pharmcol. (57): 443–460, 1979.

    Article  CAS  Google Scholar 

  6. Henry PD: Calcium ion antagonists: Mechanisms of action and clinical applications. Pract. Cardiol. (5): 145–156, 1979.

    Google Scholar 

  7. Triggle DJ, Swamy VC: Pharmacology of agents that affect calcium. Chest (78): 174–1 79, 1980.

    Google Scholar 

  8. Seminar on Calcium Channel Blockers, Part 1. Am. J. Cardiol. 46: 1045–1067, 1980.

    Google Scholar 

  9. Seminar on Calcium Channel Blockers, Part 2. Am. J. Cardiol. 47: 15 7–184, 1981.

    Google Scholar 

  10. Nayler WG: Calcium antagonists. Eur. Heart J. (1): 225–237, 1980.

    Article  CAS  PubMed  Google Scholar 

  11. Church J, Zsoter TT: Calcium antgonistic drugs: Mechanism of action. Can. J. Physiol. Pharmacol. (58): 254–264, 1980.

    Article  CAS  PubMed  Google Scholar 

  12. Berne RM: Cardiac nucleotides in hypoxia: Possible role in regulation of coronary blood flow. Am. J. Physiol. (204): 317–322, 1963.

    CAS  PubMed  Google Scholar 

  13. Rubio R, Berne RM: Release of adenosine by the normal myocardium in dog and its relationship to the regulation of coronary resistance. Circ. Res. (25): 407–415, 1969.

    Article  CAS  PubMed  Google Scholar 

  14. Berne RM: The role of adenosine in the regulation of coronary blood flow. Clrc. Res. (47): 807–813, 1980.

    Article  CAS  Google Scholar 

  15. Dutta P, Mustafa SJ: Binding of adenosine to the crude plasma membrane fraction isolated from dog coronary and carotid arteries. J. Pharmacol. Exp. Ther. (214): 496–502, 1980.

    CAS  PubMed  Google Scholar 

  16. Mustafa SJ: Cellular and molecular mechanisms of coronary flow regulation by adenosine. Mol. Cell. Biochem. (31): 67–87, 1980.

    Article  CAS  PubMed  Google Scholar 

  17. Lenke D, Brock N, Zechel HJ: Zur pharmakologie von 1,4-Bis (3-(3,4,5- trimethoxybenzoyloxy)-propyl)-perhydro-1,4-diazepin (Dilazep, INN), einer neuen koronaraktiven substanz. Arzneim.-Forsch. (22):639–651, 1972.

    CAS  Google Scholar 

  18. Hockerts T, Bogelmann G: Investigations of the cardiac and circulatory action of 2,6-Bis(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine. Arzneim.-Forsch. (9): 47–49, 1959.

    CAS  Google Scholar 

  19. Schaper WKA, Xhonneux R, Jageneau AHM, Janssen PAJ: The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator. J. Pharmac. (152): 265–274, 1966.

    CAS  Google Scholar 

  20. Sano N, Katsuki S, Kawada M: Enhancement of coronary vasodilator action of adenosine by 1,4-Bis[3(3,4,5-trimenthoxybenzoyloxy)-propyl]- perhydro-1,4-diazepine (Dilazep, INN). Arzneim.-Forsch. 22:1655–1658, 1972.

    CAS  Google Scholar 

  21. Buyniski JP, Losada M, Bierwagen ME, Gardier RW: Cerebral and coronary vascular effects of a symmetrical N,N’-disubstituted hexahydrodiazepine. J. Pharmacol. Exp. Ther. (181): 522–528, 1972.

    CAS  PubMed  Google Scholar 

  22. Katano Y, Takeda K, Otorii T, Horii D, Imai S: Effects of dilazep, dipyridamole and hexobenzine on the heart and coronary circulation. Folia Pharmacol. Jopon. 70:305–314, 1974 (Abs. in English).

    Article  CAS  Google Scholar 

  23. Mustafa SJ: Effects of coronary vasodilator drugs on the uptake and release of adenosine in cardiac cells. Biochem. Pharmacol. 28: 2617–2624, 1979.

    Article  CAS  PubMed  Google Scholar 

  24. Turnheim K, Pittner H, Kolassa N, Kraupp O: Relaxation of coronary artery strips by adenosine and acidosis. Eur. J. Pharmac. (41):217–220, 1977.

    Article  CAS  Google Scholar 

  25. Schrader J, Rubio R, Berne RM: Inhibition of slow action potentials of guinea pig atria muscle by adenosine: A possible effect on Ca2+ influx. J. Mol. Cell. Cardiol. (7): 427–433, 1975.

    Article  CAS  PubMed  Google Scholar 

  26. Fenton RA, Bruttig SP, Rubio R, Berne RM: Effect of adenosine on calcium uptake by intact and cultured vascular smooth muscle. Am. J. Phsyiol. (242):H797–H804, 1982.

    Google Scholar 

  27. Griffith SG, Meghji P, Moody CJ, Burnstock G: 8-phenyltheophylline; A potent P1-purinoceptor antagonist. Eur. J. Pharmacol. (75): 61–64, 1981.

    Article  CAS  PubMed  Google Scholar 

  28. Thyrum PT: Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria. J. Pharmacol. Exp. Ther. 188: 166–179, 1974.

    CAS  PubMed  Google Scholar 

  29. Hashimoto K, Takeda K, Katano Y, Nakagawa Y, Tsukada T, Hashimoto T, Schimamoto N, Sakai K, Otorii T, Imai S: Effects of niludipine (Bay a 7168) on the cardiovascular system; with a note on its calcium- antagonistic effects. Arzneim.-Forsch. 29: 1368–1373, 1979.

    CAS  Google Scholar 

  30. Gross GJ, Diemer MJ, Warltier DC, Hardman HF: Relaxation of potassium-depolarized canine, bovine and porcine large coronary arteries by nitroglycerin, chromonar and two dihydropyridine calcium antagonists. Gen. Pharmac. (12): 199–204, 1981.

    Article  CAS  Google Scholar 

  31. Askar AO, Mustafa SJ: Effect of calcium antagonists on the adenosine induced relaxation of bovine coronary arteries. (Abstr.). Fed. Proc. 41 (3): 1529, 1982.

    Google Scholar 

  32. Nabata H: Effects of calcium-antagonistic coronary vasodilators on myocardial contractility and membrane potentials. Japan. J. Pharmacol. (27): 239–249, 1977.

    Article  CAS  Google Scholar 

  33. Herlihy JT, Bockman EL, Berne RM, Rubio R: Adenosine relaxation of isolated vascular smooth muscle. Am. J. Physiol. (230): 1239–1243, 1976.

    CAS  PubMed  Google Scholar 

  34. Foley DH, Amsterdam EA, Mason DT: Interactions of vasoactive effects of adenosine and potassium ion on isolated feline coronary artery smooth muscle. Circ. Res. (44): 207–215, 1979.

    Article  CAS  PubMed  Google Scholar 

  35. Verhaeghe RH: Action of adenosine and adenine nucleotides on dog’s isolated veins. Am. J. Physiol. (233) H114–H121, 1977.

    PubMed  Google Scholar 

  36. Dutta P, Mustafa SJ, Jones AW: Effect of adenosine on the uptake and efflux of calcium by coronary arteries (Abstr.) Fed. Proc. 39 (3): 530, 1980.

    Google Scholar 

  37. Askar AO, Mustafa SJ: Interaction between calcium entry blockers and adenosine (Abstr.) Pharmacologists 25 (3): 244, 1983.

    Google Scholar 

  38. Imai S, Takeda K: Effect of vasodilators upon the isolated taenia coli of the guinea pig. J. Pharmacol. Exp. Therap. (156): 557–564, 1967.

    CAS  Google Scholar 

  39. Evans DS, Sehenden JA: Adenosine receptors mediating cardiac depression. Life Sei. (31): 2425–2432, 1982.

    Article  CAS  Google Scholar 

  40. Collis MG: Evidence for an A1-adenosine receptor in the guinea pig atrium. Br. J. Pharmac. (78): 207–212, 1983.

    Article  CAS  Google Scholar 

  41. Kucukhuseyin C, Kayaalp SO: Enhancement of the muscle effects of adenosine by lidoflazine and dipyridamole in isolated atria. Arch. Int. Pharmacodyn. (208): 243–250, 1974.

    CAS  PubMed  Google Scholar 

  42. Perez JE, Borda L, Schuchleib R, Henry PD: Inotropic and chronotropic effects of vasodilators. J. Pharmacol. Exp. Ther. (221): 609–613, 1982.

    CAS  PubMed  Google Scholar 

  43. Camilion de Hurtado MC, Cingolani HE: Interaction between calcium and slow channel blocking drugs on atrial rate. Naunyn-Schmiedeberg’s Arch. Pharmacol. 322:65–71, 1983.

    Article  CAS  Google Scholar 

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© 1984 Martinus Nijhoff Publishing, Boston

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Nakagawa, Y., Gudenzi, M., Mustafa, S.J. (1984). Comparison of Calcium Blocking Activities of Adenosine Potentiating Compounds With Calcium Blocking Drugs in Isolated Smooth Muscle and Atria. In: Sperelakis, N., Caulfield, J.B. (eds) Calcium Antagonists. Developments in Cardiovascular Medicine, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3810-9_21

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  • DOI: https://doi.org/10.1007/978-1-4613-3810-9_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3812-3

  • Online ISBN: 978-1-4613-3810-9

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