Skip to main content

Spinal Cord Plasticity Induced by Peripheral Nerve Injury and Some Consequences for Sensory Dysfunction

  • Chapter
Somatosensory Mechanisms

Part of the book series: Wenner-Gren Center International Symposium Series ((EMISS,volume 12))

  • 42 Accesses

Abstract

When a nerve is out, the CNS loses access to sensory information from a corresponding portion of the periphery. In addition to this loss of input, however, nerve injury also initiates several positive, and less generally appreciated processes. These include the creation of spurious afferent inputs, and the induction of CNS changes which may profoundly distort the neural processing of both spurious and remaining true signals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Brown, A.G. (1981). Organization in the Spinal Cord. Springer Verlag, Berlin

    Book  Google Scholar 

  • Calvin, Wm. H., Devor, M., Howe, J.F., (1982). Can neuralgias arise from minor demyelination? Spontaneous firing, mechanosensitivity and afterdischarge from conducting axons. Expt. Neurol., 75, 755–763

    Article  CAS  Google Scholar 

  • Cronholm, B. (1951). Phantom limbs in amputees. Acta. Psychiat. Neurol. Scand., Suppl. 72, 1–310

    CAS  Google Scholar 

  • DeSantis, M., Duckworth, J.W. (1982). Properties of primary afferent neurons from muscle which are spontaneously active after a lesion of their peripheral processes. Expt. Neurol., 75, 261–274

    Article  Google Scholar 

  • Devor, M,. (1983a). The pathophysiology and anatomy of damaged nerve. In: Textbook of Pain. (eds. P.D. Wall., R. Melzack.,) Churchill Livingston, London, In Press

    Google Scholar 

  • Devor, M. (1983b). Nerve pathophysiology and mechanisms of pain in causalgia. J. Autonom. Nerv. Syst., 7, 371–384

    Article  CAS  Google Scholar 

  • Devor, M. (1983c). Plasticity of spinal cord somatotopy in adult mammals: Involvement of relatively ineffective synapses. In: Nervous System Regeneration. (eds. A.-M. Giuffrida-Stella, B. Haber, G. Hashim, J.R., Perez -Polo) Alan R. Liss, New York, In press

    Google Scholar 

  • Devor, M., Claman, D. (1980). Mapping and plasticity of acid phosphatase afferents in the rat dorsal horn. Brain Res., 190, 17–28

    Article  PubMed  CAS  Google Scholar 

  • Devor, M., Bernstein, J.J. (1982). Abnormal impulse generation in neuromas: Electrophysiology and ultrastructure. In: Abnormal Nerves and Muscles as Impulse Generators. (eds. J. Ochoa and Wm. Culp)Oxford University Press, New York. pp. 363–380

    Google Scholar 

  • Devor, M., Merrill, E., Wall, P.D. (1977). Dorsal horn cells responding to stimulation of distant dorsal roots. J. physiol., 270, 519–531

    PubMed Central  PubMed  CAS  Google Scholar 

  • Devor, M., Schonfeld, O., Seltzer, Z., Wall, P.D. (1979). Two modes of cutaneuus reinnervat1on following peripheral nerve injury. J. Comp. Neurol., 185, 211–220

    Article  PubMed  CAS  Google Scholar 

  • Devor, M., Wall, P.D., (1978). Reorganization of the spinal cord sensory map after peripheral nerve injury. Nature, 276, 75–76

    Article  PubMed  CAS  Google Scholar 

  • Devor, M., Wall, P.D. (1981a). The effect of peripheral nerve injury on receptive fields of cells in the cat spinal cord. J. Comp. Neurol., 199, 277–291

    Article  CAS  Google Scholar 

  • Devor, M., Wall, P.D. (1981b). Plasticity in the spinal cord sensory map following peripheral nerve injury in ruts. J. Neurosof., 1, 679–684

    CAS  Google Scholar 

  • Dostrovsky, J.D., Ball, G.J., Hu, J.W., Sessle, B.J. (1982). Functional changes associated with partial tooth pulp removal in neurons of the trigem1nal spinal tract nucleus, and their clinical implications. In: Anatomical, Physiological and Pharmacological Aspects of Trigeminal Pain. (eds. B. Mattews and R.G. Hill ). Excerpta Medica, Amsterdam. Pp. 293–310

    Google Scholar 

  • Egger, M.D., Freeman, N.C.G., Proshansky, E. (1981). The significance of laminar arrangement. In: Spinal Cord (eds. A.G. Brown and M. Rethelyi) Scottish Academic Press, Edinburgh

    Google Scholar 

  • Goldberger, M.E., Murray, M., (1974). Restitution of function and collateral sprouting in the cat spinal cord: The deafferented animal. J. Comp., Neurol., 158, 37–54

    Article  CAS  Google Scholar 

  • Haber, W.B. (1955). Effects of loss of limb on sensory functions. J. psychol, 40, 115–123

    Article  Google Scholar 

  • Howe, J.F. (1983). Phantom limb pain - a re-afferentation syndrome. Pain, 15, 101–107

    Article  Google Scholar 

  • Jackson, P.C., Diamond, J. (1981). Regenerating axons reclaim sensory targets from collateral nerve sprouts. Science, 214, 926–928

    Article  PubMed  CAS  Google Scholar 

  • Koerber, H.R., Brown, P.B. (1982). Somatotopic organization of hindlimb cutaneous nerve projections to cat dorsal horn. J. Neurophysiol., 48, 418–489

    Google Scholar 

  • Lisney, S.J.W. (1983). Changes in the somatotopic organization of the cat lumbar spinal cord following peripheral nerve transection and regeneration. Brain Res., 259, 31–39

    Article  PubMed  CAS  Google Scholar 

  • Lisney, S.J.W., Devor, M. (1983). Interactions between fibers in damaged peripheral nerve in the rat. In Press

    Google Scholar 

  • Liu, C.N., Chambers, W.W. (1958). Intraspinal sprouting of dorsal root axons. Arch. Neurol. Psychiat., 79, 46–61

    Article  CAS  Google Scholar 

  • Mendell, L.M., Sassoon, E.M., Wall P.D. (1978). Properties of synaptic linkage from long ranging afferents onto dorsal horn neurons in normal and deafferented cats. J. physiol., 285, 299–310

    PubMed Central  PubMed  CAS  Google Scholar 

  • Merrill, E.G., Wall, P.D. (1972) Factors forming the edge of a receptive field. The presence of relatively ineffective afferents. J. Physiol., 226, 825–846

    PubMed Central  PubMed  CAS  Google Scholar 

  • Marzenich, M.M., Kaas, J.H. (l982). Recoganization of mammalian somatosensory cortex following peripheral nerve injury. TINS, Dec., 433–436

    Google Scholar 

  • Pomerantz, B.H., Markus, H., Krushelnycky, D. (1983). Spread of saphenous somatotopic projection map in spinal cord and behavioral effects after chronic sciatic denervation in adult rat. In Press

    Google Scholar 

  • Rodin, B.E., Sampogna, S.L., Kruger, L. (1983). An examination of intraspinal sprouting in dorsal root axons with the tracer horseradish peroxidase. J. Comp. Neurol., 215, 187–198

    Article  PubMed  CAS  Google Scholar 

  • Seltzer, Z., Devor, M., (1979). Ephaptic transmission in chronically damaged peripheral nerves. Neurology, 29, 1061–1064

    Article  PubMed  CAS  Google Scholar 

  • Seltzer, Z., Devor, M., (1983). Effect of nerve section on the spinal distribution of neighboring nerves. In press

    Google Scholar 

  • Teuber, H.L., Krieger, H.P., Rendell, M.B., (1949). Reorganization of sensory function in amputation stumps: Two-point discrimination. Fed. Proc., 8, 156

    Google Scholar 

  • Wall, P.D. (1977). The presence of ineffective synapses and the circumstances which unmask them. Phil. Trans. Roy. Soc. B., 278. 361–372

    Article  CAS  Google Scholar 

  • Wall, P.D. (1982). The effect of peripheral nerve lesions and of neonatal capsaicin in the rat on primary afferent depolarization. J. Physiol., 329, 2l–35

    Google Scholar 

  • Wall, P.D., Devur, M. (1981). The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord. Brain Res., 209, 95–111

    Article  PubMed  CAS  Google Scholar 

  • Wall, P.D., Devor, M. (1983). Sensory impulses originate in dorsal root ganglia in normal and nerve injured rats. In press

    Google Scholar 

  • Wall, P.D., Gutnick, M. (1974). Ongoing activity in peripheral nerves: The physiology and pharmacology of impulses originating from a neuroma. Exp. Neurol., 43, 580–593

    Article  PubMed  CAS  Google Scholar 

  • Wall, P.D., Mills, M., Fitzgerald M., Gibson, S.J., (1982). Chronic blockade of sciatic nerve transmission by tetrodotoxin does not produce central changes in the dorsal horn of the spinal cord of the rat. Neurosci. Lett. 38, 315–320

    Article  Google Scholar 

  • Woolf, C.J.,Wall, P.D. (1982). Chronic peripheral nerve section diminishes the primary afferent A-fiber mediated inhibition of rat dorsal horn neurons. Brain Res., 242, 77–85

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 The Wenner-Gren Center

About this chapter

Cite this chapter

Devor, M. (1984). Spinal Cord Plasticity Induced by Peripheral Nerve Injury and Some Consequences for Sensory Dysfunction. In: von Euler, C., Franzén, O., Lindblom, U., Ottoson, D. (eds) Somatosensory Mechanisms. Wenner-Gren Center International Symposium Series, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2807-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2807-0_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9728-4

  • Online ISBN: 978-1-4613-2807-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics