Skip to main content
  • 59 Accesses

Abstract

In 1998, 539,000 percutaneous transluminal coronary angioplasty (PTCA) procedures were performed in the United States, an increase of 248% since 1987 [1]. Most of these interventions were followed by stenting. The advent of stents has revolutionized interventional cardiology; however, the Achilles’ heel of stenting is in-stent restenosis (ISR). In this chapter, the patterns, predictors, and treatment options for ISR are outlined.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Referenzen

  1. Heart and Stroke Statistical Update. In: American Heart Association; 2001.

    Google Scholar 

  2. Kimura T, Tamura T, Yokoi H, et al.: Long-term clinical and angiographic follow-up after placement of Palmaz-Schatz coronary stent: a single center experience.J Interv Cardiol 1994, 7:129–139.

    CAS  PubMed  Google Scholar 

  3. Mehran R, Dangas G, Abizaid AS, et al.: Angiographic patterns of in-stent restenosis: classification and implications for long-term outcome. Circulation 1999, 100:1872–1878.

    CAS  PubMed  Google Scholar 

  4. Mintz GS, Popma JJ, Hong MK, et al.: Intravascular ultrasound to discern device-specific effects and mechanisms of restenosis. Am J Cardiol 1996, 78:18–22.

    CAS  PubMed  Google Scholar 

  5. van Beusekom HM, van der Giessen WJ, van Suylen R, et al.: Histology after stenting of human saphenous vein bypass grafts: observations from surgically excised grafts 3 to 320 days after stent implantation. J Am Coll Cardiol 1993, 21:45–54.

    PubMed  Google Scholar 

  6. Anderson PG, Bajaj RK, Baxley WA, et al.: Vascular pathology of balloon-expandable flexible coil stents in humans. J Am Coll Cardiol 1992, 19:372–381.

    CAS  PubMed  Google Scholar 

  7. Gordon PC, Gibson CM, Cohen DJ, et al.: Mechanisms of restenosis and redilation within coronary stents—quantitative angiographic assessment. J Am Coll Cardiol 1993, 21:1166–1174.

    CAS  PubMed  Google Scholar 

  8. Hoffmann R, Mintz GS, Dussaillant GR, et al.: Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study. Circulation 1996, 94:1247–1254.

    CAS  PubMed  Google Scholar 

  9. Abizaid A, Kornowski R, Mintz GS, et al.: The influence of diabetes mellitus on acute and late clinical outcomes following coronary stent implantation. J Am Coll Cardiol 1998, 32:584–589.

    CAS  PubMed  Google Scholar 

  10. Carrozza JP Jr, Kuntz RE, Fishman RF, et al.: Restenosis after arterial injury caused by coronary stenting in patients with diabetes mellitus. Ann Intern Med 1993, 118:344–349.

    PubMed  Google Scholar 

  11. Dauerman HL, Bairn DS, Cutlip DE, et ah: Mechanical debulking versus balloon angioplasty for the treatment of diffuse in-stent restenosis. Am J Cardiol 1998, 82:277–284.

    CAS  PubMed  Google Scholar 

  12. Kereiakes D, Linnemeier TJ, Bairn DS, et al.: Usefulness of stent length in predicting in-stent restenosis (the Multi-Link stent trials). Am J Cardiol 2000, 86:336–341.

    CAS  PubMed  Google Scholar 

  13. Lee SG, Lee CW, Hong MK, et al.: Predictors of diffuse-type in-stent restenosis after coronary stent implantation. Catheter Cardiovasc Interv 1999,47:406–409,410.

    CAS  PubMed  Google Scholar 

  14. Sheiban I, Leonardo F, Rosano GM, et al.: Predictors of long-term clinical outcome in patients undergoing multiple vessel stenting for coronary artery disease. Ital Heart J 2000, 1:480–486.

    CAS  PubMed  Google Scholar 

  15. Kastrati A, Schomig A, Elezi S, et al.: Predictive factors of restenosis after coronary stent placement.J Am Coll Cardiol 1997, 30:1428–1436.

    CAS  PubMed  Google Scholar 

  16. Gruberg L, Hong MK, Mintz GS, et al.: Optimally deployed stents in the treatment of restenotic versus de novo lesions. Am J Cardiol 2000, 85:333–337.

    CAS  PubMed  Google Scholar 

  17. Klugherz BD, Meneveau NF, Kolansky DM, et al.: Predictors of clinical outcome following percutaneous intervention for in-stent restenosis. Am J Cardiol 2000, 85:1427–1431.

    CAS  PubMed  Google Scholar 

  18. Kasaoka S, Tobis JM, Akiyama T, et al.: Angiographic and intravascular ultrasound predictors of in-stent restenosis.J Am Coll Cardiol 1998, 32:1630–1635.

    CAS  PubMed  Google Scholar 

  19. Gupta A, Kerkar PG, Vajifdar BU, et al.: Restenosis after coronary stenting— incidence and predictors.J Assoc Physicians India 2001, 49:336–342.

    CAS  PubMed  Google Scholar 

  20. Ribichini F, Steffenino G, Dellavalle A, et al.: Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme: a major risk factor and a marker of risk for coronary stent restenosis. Circulation 1998, 97:147–154.

    CAS  PubMed  Google Scholar 

  21. Mintz GS, Popma JJ, Pichard AD, et al.: Intravascular ultrasound predictors of restenosis after percutaneous transcatheter coronary revascularization. J Am Coll Cardiol 1996, 27:1678–1687.

    CAS  PubMed  Google Scholar 

  22. Brito FSJr, Caixeta AM, Rati MA, et al.: Patient-related and angiographic predictors of restenosis after excimer laser coronary angioplasty.J Invasive Cardiol 1998, 10:162–168.

    PubMed  Google Scholar 

  23. Ellis SG, Savage M, Fischman D, et al.: Restenosis after placement of Palmaz-Schatz stents in native coronary arteries. Initial results of a multicenter experience. Circulation 1992, 86:1836–1844.

    CAS  PubMed  Google Scholar 

  24. Kini A, Marmur JD, Dangas G, et al.: Angiographic patterns of in-stent restenosis and implications on subsequent revascularization. Catheter Cardiovasc Interv 2000, 49:23–29.

    CAS  PubMed  Google Scholar 

  25. Choussat R, Klersy C, Black AJ, et al.: Long-term (8 years or longer) outcome after Palmaz-Schatz stent implantation. Am J Cardiol 2001, 88:10–16.

    CAS  PubMed  Google Scholar 

  26. Kornowski R, Mehran R, Satler LF, et al.: Procedural results and late clinical outcomes following multivessel coronary stenting.J Am Coll Cardiol 1999, 33:420–426.

    CAS  PubMed  Google Scholar 

  27. DeServi S, Mariani G, Bossi I, et al.: One-year outcome in multivessel coronary disease patients undergoing coronary stenting. Catheter Cardiovasc Interv 1999, 48:343–349.

    PubMed  Google Scholar 

  28. Hoffmann R, Mintz GS, Mehran R, et al.: Intravascular ultrasound predictors of angiographic restenosis in lesions treated with Palmaz-Schatz stents. J Am Coll Cardiol 1998, 31:43–49.

    CAS  PubMed  Google Scholar 

  29. Finci L, Ferraro M, Nishida T, et al.: Coronary stenting beyond standard indications. Immediate and follow-up results. Ital Heart J 2000, 1:739–748.

    CAS  PubMed  Google Scholar 

  30. Sheiban I, Albiero R, Marsico F, et al.: Immediate and long-term results of “T” stenting for bifurcation coronary lesions. Am J Cardiol 2000, 85:1141–1144, A9.

    CAS  PubMed  Google Scholar 

  31. Bauters C, Hubert E, Prat A, et al.: Predictors of restenosis after coronary stent implantation. J Am Coll Cardiol 1998, 31:1291–1298.

    CAS  PubMed  Google Scholar 

  32. Jeong MH, Kim SH, Ahn YK, et al.: Predictive factors for the second restenosis after coronary interventions. Catheter Cardiovasc Interv 2000, 50:34–39.

    CAS  PubMed  Google Scholar 

  33. Kastrati A, Schomig A, Elezi S, et al.: Prognostic value of the modified American College of Cardiology/American Heart Association stenosis morphology classification for long-term angiographic and clinical outcome after coronary stent placement. Circulation 1999, 100:1285–1290.

    CAS  PubMed  Google Scholar 

  34. Kastrati A, Schomig A, Elezi S, et al.: Prognostic value of the modified American College of Cardiology/American Heart Association stenosis morphology classification for long-term angiographic and clinical outcome after coronary stent placement. Circulation 1999, 100:1285–1290.

    CAS  PubMed  Google Scholar 

  35. Kastrati A, Dirschinger J, Boekstegers P, et al.: Influence of stent design on 1-year outcome after coronary stent placement: a randomized comparison of five stent types in 1, 147 unselected patients. Catheter Cardiovasc Interv 2000, 50:290–297.

    CAS  PubMed  Google Scholar 

  36. Kobayashi Y, DeGregorio J, Kobayashi N, et al.: Stented segment length as an independent predictor of restenosis.J Am Coll Cardiol 1999, 34:651–659.

    CAS  PubMed  Google Scholar 

  37. Kornowski R, Bhargava B, Fuchs S, et al.: Procedural results and late clinical outcomes after percutaneous interventions using long (25 mm or greater) versus short (20 mm or less) stents.J Am Coll Cardiol 2000, 35:612–618.

    CAS  PubMed  Google Scholar 

  38. Kastrati A, Elezi S, Dirschinger J, et al.: Influence of lesion length on restenosis after coronary stent placement. Am J Cardiol 1999, 83:1617–1622.

    CAS  PubMed  Google Scholar 

  39. Kastrati A, Schomig A, Dirschinger J, et al.: A randomized trial comparing stenting with balloon angioplasty in small vessels in patients with symptomatic coronary artery disease. Circulation 2000, 102:2593–2598.

    CAS  PubMed  Google Scholar 

  40. Kastrati A, Mehilli J, Dirschinger J, et al.: Restenosis after coronary placement of various stent types. Am J Cardiol 2001, 87:34–39.

    CAS  PubMed  Google Scholar 

  41. Park SW, Park HK, Hong MK, et al.: Comparison of slotted tube versus coil stent implantation for ostial left anterior descending coronary artery stenosis: initial and late clinical outcomes.J Korean Med Sci 1998, 13:483–487.

    CAS  PubMed Central  PubMed  Google Scholar 

  42. Carrozza JP Jr, Hosley SE, Cohen DJ, et al.: In vivo assessment of stent expansion and recoil in normal porcine coronary arteries: differential outcome by stent design. Circulation 1999, 100:756–760.

    PubMed  Google Scholar 

  43. Ho DS, Liu MW, Iyer S, et al.: Sizing the Gianturco-Roubin coronary flexible coil stent. Cathet Cardiovasc Diagn 1994, 32:242–248.

    CAS  PubMed  Google Scholar 

  44. Vrints CJ, Cools F, Bosmans J, et al.: Acute luminal gain after stenting: comparison of Gianturco-Roubin and Palmaz-Schatz stents.J Invasive Cardiol 1996, 8:135–143.

    PubMed  Google Scholar 

  45. Maclsaac AI, Ellis SG, Muller DW, et al.: Comparison of three coronary stents: clinical and angiographic outcome after elective placement in 134 consecutive patients. Cathet Cardiovasc Diagn 1994, 33:199–204.

    Google Scholar 

  46. Silber S, Seidel N, Muehling H, et al.: In-stent restenosis using newer stent designs available in Germany (abstract). J Am Coll Cardiol 1998, 1033–1106.

    Google Scholar 

  47. Yokoi H, Kimura T, Hamasaki N, et al.: Coronary stenting for STRESS/ BENESTENT equivalent lesions: Comparison of four different types of stent. J Am Coll Cardiol 1998, 1137–1164.

    Google Scholar 

  48. Kastrati A, Schomig A, Dirschinger J, et al.: Increased risk of restenosis after placement of gold-coated stents: results of a randomized trial comparing gold-coated with uncoated steel stents in patients with coronary artery disease. Circulation 2000, 101:2478–2483.

    CAS  PubMed  Google Scholar 

  49. Kastrati A, Mehilli J, Dirschinger J, et al.: Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO) trial. Circulation 2001, 103:2816–2821.

    CAS  PubMed  Google Scholar 

  50. Kuntz RE, Gibson CM, Nobuyoshi M, et al.: Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy. J Am Coll Cardiol 1993, 21:15–25.

    CAS  PubMed  Google Scholar 

  51. Hong MK, Park SW, Mintz GS, et al.: Intravascular ultrasonic predictors of angiographic restenosis after long coronary stenting. Am J Cardiol 2000, 85:441–45.

    CAS  PubMed  Google Scholar 

  52. Hasdai D, Garratt KN, Grill DE, et al.: Effect of smoking status on the long-term outcome after successful percutaneous coronary revascularization. N Engl J Med 1997, 336:755–761.

    CAS  PubMed  Google Scholar 

  53. Jolly N, Ellis SG, Franco I, et al.: Coronary artery stent restenosis responds favorably to repeat interventions. Am J Cardiol 1999, 83:1565–1568, A7.

    CAS  PubMed  Google Scholar 

  54. Koch W, Kastrati A, Mehilli J, et al.: Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene is not associated with restenosis after coronary stent placement. Circulation 2000, 102:197–202.

    CAS  PubMed  Google Scholar 

  55. Kastrati A, Schomig A, Seyfarth M, et al.: PIA polymorphism of platelet glycoprotein Ilia and risk of restenosis after coronary stent placement. Circulation 1999, 99:1005–1010.

    CAS  PubMed  Google Scholar 

  56. Hoffmann R, Mintz GS: Coronary in-stent restenosis—predictors, treatment and prevention. Eur Heart J 2000, 21:1739–1749.

    CAS  PubMed  Google Scholar 

  57. Carrozza JP, Jr.: In-stent restenosis: should an old device treat a new problem? J Am Coll Cardiol 2000, 35:1577–1579.

    PubMed  Google Scholar 

  58. Bairn DS, Levine MJ, Leon MB, et al.: Management of restenosis within the Palmaz-Schatz coronary stent (the U.S. multicenter experience). Am J Cardiol 1993, 71:364–366.

    Google Scholar 

  59. Reimers B, Moussa I, Akiyama T, et al.: Long-term clinical follow-up after successful repeat percutaneous intervention for stent restenosis.J Am Coll Cardiol 1997, 30(1):186–192.

    CAS  PubMed  Google Scholar 

  60. Bossi I, Klersy C, Black AJ, et al.: In-stent restenosis: long-term outcome and predictors of subsequent target lesion revascularization after repeat balloon angioplasty. J Am Coll Cardiol 2000, 35:1569–1576.

    CAS  PubMed  Google Scholar 

  61. Mehran R, Mintz GS, Popma JJ, et al.: Mechanisms and results of balloon angioplasty for the treatment of in-stent restenosis. Am J Cardiol 1996, 78:618–622.

    CAS  PubMed  Google Scholar 

  62. Eltchaninoff H, Koning R, Tron C, et al.: Balloon angioplasty for the treatment of coronary in-stent restenosis: immediate results and 6-month angiographic recurrent restenosis rate. J Am Coll Cardiol 1998, 32(4):980–984.

    CAS  PubMed  Google Scholar 

  63. Mehran R, Dangas G, Abizaid A, et al.: Treatment of focal in-stent restenosis with balloon angioplasty alone versus stenting: Short- and long-term results. Am Heart J 2001, 141:610–614.

    CAS  PubMed  Google Scholar 

  64. Shiran A, Mintz GS, Waksman R, et al.: Early lumen loss after treatment of in-stent restenosis: an intravascular ultrasound study. Circulation 1998, 98:200–203.

    CAS  PubMed  Google Scholar 

  65. Alfonso F, Cequier A, Zueco J, et al.: Stenting the stent: initial results and long-term clinical and angiographic outcome of coronary stenting for patients with in-stent restenosis. Am J Cardiol 2000, 85:327–332.

    CAS  PubMed  Google Scholar 

  66. Alfonso F: RIBS: Repeat stenting shows benefits in large but not small vessels. In: American College of Cardiology 50th Annual Scientific Sessions; 2000; Orlando, FL.

    Google Scholar 

  67. Radke PW, Klues HG, Haager PK, et al.: Mechanisms of acute lumen gain and recurrent restenosis after rotational atherectomy of diffuse in-stent restenosis: a quantitative angiographic and intravascular ultrasound study.J Am Coll Cardiol 1999, 34:33–39.

    CAS  PubMed  Google Scholar 

  68. Mehran R, Dangas G, Mintz GS, et al.: In-stent restenosis: “The great equalizer” —8 disappointing clinical outcomes with all interventional strategies. In: American College of Cardiology 48th Annual Scientific Session; 1999; New Orleans, LA. Abstract 63A.

    Google Scholar 

  69. Sharma SK, Kini A, King T, et al.: Randomized trial of rotational atherectomy versus balloon angioplasty for diffuse in-stent restenosis. Final results (abstract). Circulation 2000, 102:11–730.

    Google Scholar 

  70. Ferguson JJ: Meeting highlights: highlights of the 22nd Congress of the European Society of Cardiology. Circulation 2001, 103:E41-E45.

    Google Scholar 

  71. Kobayashi Y, De Gregorio J, Kobayashi N, et al.: Lower restenosis rate with stenting following aggressive versus less aggressive rotational atherectomy. Catheter Cardiovasc Interv 1999, 46:406–414.

    CAS  PubMed  Google Scholar 

  72. Strauss BH, Umans VA, van Suylen RJ, et al.: Directional atherectomy for treatment of restenosis within coronary stents: clinical, angiographic and histologic results. J Am Coll Cardiol 1992, 20:1465–1473.

    CAS  PubMed  Google Scholar 

  73. Mahdi NA, Pathan AZ, Harrell L, et al.: Directional coronary atherectomy for the treatment of Palmaz-Schatz in-stent restenosis. Am J Cardiol 1998, 82:1345–1351.

    CAS  PubMed  Google Scholar 

  74. Meyer T, Schmidt T, Buchwald A, et al.: Stent wire cutting during coronary directional atherectomy. Clinical Cardiology 1993, 16:450–452.

    CAS  PubMed  Google Scholar 

  75. Mehran R, Mintz GS, Satler LF, et al.: Treatment of in-stent restenosis with excimer laser coronary angioplasty: mechanisms and results compared with PTCA alone. Circulation 1997, 96:2183–2189.

    CAS  PubMed  Google Scholar 

  76. Giri S, Ito S, Lansky AJ, et al.: Clinical and angiographic outcome in the laser angioplasty for restenotic stents (LARS) multicenter registry. Catheter Cardiovasc Interv 2001, 52:24–34.

    CAS  PubMed  Google Scholar 

  77. Mehran R, Dangas G, Mintz GS, et al.: Treatment of in-stent restenosis with excimer laser coronary angioplasty versus rotational atherectomy: comparative mechanisms and results. Circulation 2000, 101:2484–2489.

    CAS  PubMed  Google Scholar 

  78. Albiero R, Nishida T, Karvouni E, et al.: Cutting balloon angioplasty for the treatment of in-stent restenosis. Catheter Cardiovasc Interv 2000, 50:452–459.

    CAS  PubMed  Google Scholar 

  79. Freitas Junior JO, Berti SL, Bonfa JG, et al.: Cutting balloon angioplasty for intrastent restenosis treatment. Arq Bras Cardiol 1999, 72:615–620.

    CAS  PubMed  Google Scholar 

  80. Molstad P, Myreng Y, Golf S, et al.: The Barath Cutting Balloon versus conventional angioplasty. A randomized study comparing acute success rate and frequency of late restenosis. Scand Cardiovasc J 1998, 32:79–85.

    CAS  PubMed  Google Scholar 

  81. Muramatsu T, Tsukahara R, Ho M, et al.: Efficacy of cutting balloon angioplasty for in-stent restenosis: an intravascular ultrasound evaluation.J Invasive Cardiol 2001, 13:439–444.

    CAS  PubMed  Google Scholar 

  82. Chevalier B, Royer T, Guyon P, et al.: Treatment of in-stent restenosis: Short and midterm results of a pilot study between balloon and cutting balloon (abstract). J Am Coll Cardiol 1999, 33:63A.

    Google Scholar 

  83. Mizobe M, Oohata K, Osada T: The efficacy of cutting balloon for in-stent restenosis: Compared with conventional balloon angioplasty (abstract). Circulation 1999, 100:1–308.

    Google Scholar 

  84. Adamian M, Marsico F, Briguori C, et al.: Cutting balloon for treatment of in-stent restenosis: A matched comparison with conventional angioplasty and rotational atherectomy (abstract). Circulation 1999, 100:1–305.

    Google Scholar 

  85. Adamian M, Colombo A, Briguori C, et al.: Cutting balloon angioplasty for the treatment of in-stent restenosis: a matched comparison with rotational atherectomy, additional stent implantation and balloon angioplasty.J Am Coll Cardiol 2001, 38:672–679.

    CAS  PubMed  Google Scholar 

  86. Lauer B, Schmidt E, Stellbring S, et al.: Cutting balloon angioplasty for treatment of in-stent restenosis (abstract). Circulation 2000, 102:11–365.

    Google Scholar 

  87. Waksman R, Bhargava B, White L, et al.: Intracoronary beta-radiation therapy inhibits recurrence of in-stent restenosis. Circulation 2000, 101:1895–1898.

    CAS  PubMed  Google Scholar 

  88. Waksman R, White RL, Chan RC, et al.: Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation 2000, 101:2165–2171.

    CAS  PubMed  Google Scholar 

  89. Verin V, Popowski Y, de Bruyne B, et al.: Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. The Dose-Finding Study Group. N Engl J Med 2001, 344:243–249.

    CAS  PubMed  Google Scholar 

  90. Teirstein PS, Massullo V, Jani S, et al.: Catheter-based radiotherapy to inhibit restenosis after coronary stenting. N Engl J Med 1997, 336:1697–1703.

    CAS  PubMed  Google Scholar 

  91. Condado JA, Waksman R, Gurdiel O, et al.: Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans. Circulation 1997, 96:727–732.

    CAS  PubMed  Google Scholar 

  92. Malhotra S, Teirstein PS: The SCRIPPS trial—catheter-based radiotherapy to inhibit coronary restenosis. J Invasive Cardiol 2000, 12:330–332.

    CAS  PubMed  Google Scholar 

  93. Waksman R: Intracoronary gamma radiation for diffuse in-stent restenosis. J Am Coll Cardiol 2000, 36:315–316.

    Google Scholar 

  94. Leon MB, Teirstein PS, Moses JW, et al.: Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. N Engl J Med 2001, 344:250–256.

    CAS  PubMed  Google Scholar 

  95. Teirstein P, Moses JW, Casterella PJ, et al.: Late thrombosis after coronary radiation may be eliminated by longer antiplatelet therapy and reduced stenting: The Scripps III results. J Am Coll Cardiol 2001, 37:60A.

    Google Scholar 

  96. King SB3rd, Williams DO, Chougule P, et al.: Endovascular beta-radiation to reduce restenosis after coronary balloon angioplasty: results of the beta energy restenosis trial (BERT). Circulation 1998, 97:2025–2030.

    PubMed  Google Scholar 

  97. 97.Raizner AE, Oesterle SN, Waksman R, et al.: Inhibition of restenosis with beta-emitting radiotherapy: report of the Proliferation Reduction with Vascular Energy Trial (PREVENT). Circulation 2000, 102:951–958.

    CAS  PubMed  Google Scholar 

  98. Verin V, Urban P, Popowski Y, et al.: Feasibility of intracoronary beta-irradiation to reduce restenosis after balloon angioplasty. A clinical pilot study. Circulation 1997, 95:1138–1144.

    CAS  PubMed  Google Scholar 

  99. 99.Kleiman NS, Califf RM: Results from late-breaking clinical trials sessions at ACCIS 2000 and ACC 2000. American College of Cardiology.J Am Coll Cardiol 2000, 36:310–325.

    CAS  PubMed  Google Scholar 

  100. Loskey W: Late clinical and angiographic outcomes after use of Sr-90 beta radiation for the treatment of in-stent restenosis from the START 90 (Stents and Radiation Therapy 90) trial. Paper presented at: Annual Meeting of the American Heart Association; November 12–15, 2000; New Orleans, LA.

    Google Scholar 

  101. Sianos G, Kay IP, Costa MA, et al.: Geographical miss during catheter-based intracoronary beta-radiation: incidence and implications in the BRIE study. Beta-Radiation In Europe. J Am Coll Cardiol 2001, 38:415–420.

    CAS  PubMed  Google Scholar 

  102. Sousa JE, Costa MA, Abizaid A, et al.: Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation 2001, 103:192–195.

    CAS  PubMed  Google Scholar 

  103. Capper EA, Roshak AK, Bolognese BJ, et al.: Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis.J Pharmacol Exp Ther 2000, 295:1061–1069.

    CAS  PubMed  Google Scholar 

  104. Holmes D, Fitzgerald P, Goldberg S, et al.: The PRESTO (prevention of restenosis with tranilast and its outcomes) protocol: a double-blind, placebo-controlled trial. Am Heart J 2000, 139:23–31.

    CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Denktas, A.E., Mathew, V. (2003). In-stent Restenosis. In: Holmes, D.R., Mathew, V. (eds) Atlas of Interventional Cardiology. Current Medicine Group, London. https://doi.org/10.1007/978-1-4613-1091-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1091-4_6

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-0808-0

  • Online ISBN: 978-1-4613-1091-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics