Abstract
Earlier studies have suggested that glial cells may influence neuronal signalling in the brain. In particular, uptake and metabolism by glial cells may terminate the actions of the catechol aminergic transmitters released from neurons (Henn and Hamberger, 1971; Pelton et al., 1981; Kimelberg and Pelton, 1983). Thus, regulation of glial transport and metabolic activities may provide a mechanism for modulating neurotransmission. Ascorbic acid is stored within catecholaminergic neurons and is secreted with neurotransmitters (O’Neill et al., 1984; Kratzing et al., 1985). One function for ascorbic acid is the retardation of oxidative processes that degrade and inactivate catecholamines; in other words, ascorbic acid may serve as a chemical preservative for catecholamines within neurons and in extracellular fluid. However, because the termination of the neurophysiological actions of catecholamines also is effected by cellular uptake, it is of interest to know if ascorbic acid alters the catecholamine uptake process.
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© 1988 The Humana Press Inc.
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Wilson, J.X., Walz, W. (1988). Catecholamine Uptake into Cultured Mouse Astrocytes. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_28
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_28
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