Skip to main content
SpringerLink
Log in

Conclusions and Clinical Implications

  • Chapter
Soft Tissue Ossification

  • 23 Accesses

Abstract

The study of diseases which are characterized by soft tissue ossification has both pathological and physiological importance. Once the pathogenesis in these diseases is understood, this should provide a rational basis for both treatment and prophylaxis—areas which up to now have been generally unsatisfactory. Moreover, insight into the pathogenesis of ectopic ossification will no doubt lead to an understanding of the physiological situation in which the soft tissues do not ossify. This in turn will lead towards the broader goal of an understanding of the regulation of other aspects of normal bone production.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ashton BA, Allen TD, Howlett CR, Eaglesom CC, Hattori A, Owen M (1980) Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop 151: 294–307

    PubMed  Google Scholar 

  • Bassett CAL, Pilla AA, Pawluk RJ (1977) A non-operative salvage of surgically-resistant pseudarthrosis and non-unions by pulsing electromagnetic fields. A preliminary report. Clin Orthop 124: 128–143

    PubMed  Google Scholar 

  • Brewerton DA, James DCO (1975) The histocompatibility antigen (HLA B27) and disease. Semin Arthritis Rheum 4: 191–207

    Article  CAS  PubMed  Google Scholar 

  • Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DCO, Sturrock RD (1973) Ankylosing spondylitis and HLA B27. Lancet I: 904–907

    Article  Google Scholar 

  • Cole JP (1937) A study of Osgood-Schlatter disease. Surg Gynecol Obstet 65: 55–67

    Google Scholar 

  • Connor JM (1981) A national investigation into the clinical, genetic and pathogenetic aspects of fibrodysplasia ossificans progressiva. MD thesis, University of Liverpool

    Google Scholar 

  • DeLee JG, Ferrari A, Charnley J (1976) Ectopic bone following low friction arthroplasty of the hip. Clin Orthop 121: 53–59

    PubMed  Google Scholar 

  • Evans EB (1978) Musculoskeletal changes complicating burns. In: Epps CH Jr (ed) Complications in orthopaedic surgery. JB Lippincott, Philadelphia Toronto

    Google Scholar 

  • Friedenberg ZB, Harlow MC, Brighton CT (1971) Healing of nonunion of the medial malleolus by means of direct current—a case report. J Trauma 11: 883–885

    Article  CAS  PubMed  Google Scholar 

  • Garrett AC (1860) Electrophysiology and electrotherapeutic. Boston

    Google Scholar 

  • Glowacki J, Kaban LB, Murray JE, Folkman J, Mulliken JB (1981) Application of the biological principle of induced osteogenesis for craniofacial defects. Lancet I: 959–962

    Article  Google Scholar 

  • Gray DH, Speak KS (1979) The control of bone induction in soft tissues. Clin Orthop 143: 245–250

    PubMed  Google Scholar 

  • Hartshorne E (1841) Pseudarthrosis. Am J Med Sci 1: 121–156

    Article  Google Scholar 

  • Hunter T, Dubo HIC, Hildahl CR, Smith NJ, Schroeder ML (1980) Histocompatibility antigens in patients with spinal cord injury or cerebral damage complicated by heterotopic ossification. Rheumatol Rehabil 19: 97–99

    Article  CAS  PubMed  Google Scholar 

  • Irving JT, LeBolt SC, Schneider EL (1981) Ectopic bone and ageing. Clin Orthop 154: 249–253

    PubMed  Google Scholar 

  • Jonck LM, Eriksson C (1975) Some factors affecting bone formation. A review. S Afr Med J 49: 1747–1753

    CAS  PubMed  Google Scholar 

  • Lambert JR, Wright V, Rajah SM, Moll JMH (1976) Histocompatibility antigens in psoriatic arthritis. Ann Rheum Dis 35: 526–530

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Larson JM, Michalski JP, Collacott EA, Eltorai D, McCombs CC, Madorsky JB (1981) Increased prevalence of HLA B27 in patients with ectopic ossification following traumatic cord injury. Rheumatol Rehabil 20: 193–197

    Article  CAS  PubMed  Google Scholar 

  • McKusick VA (1980) The anatomy of the human genome. J Hered 71: 370–391

    CAS  PubMed  Google Scholar 

  • Mattingly PC, Mowat AG (1980) HLA antigens in patients with ectopic ossification after total hip replacement. J Rheumatol 7: 582

    CAS  PubMed  Google Scholar 

  • Minaire P, Beteul H, Pilonchery G (1978) Système HLA chez les blessĂ©s mĂ©dullaires atteints de para-ostĂ©o-arthropathies neurogènes. Nouv Presse Med 7: 3044

    CAS  PubMed  Google Scholar 

  • Montgomery WW, van Orman P (1967) The inhibitory effect of adipose tissue on osteogenesis. Ann Otol Rhinol Laryngol 76: 988–997

    CAS  PubMed  Google Scholar 

  • Morris RI, Metzger AL, Bluestone R, Terasaki DI (1974) HL-A-W27—A useful discriminator in the arthropathies of inflammatory bowel disease. N Engl J Med 290: 1117–1119

    Article  CAS  PubMed  Google Scholar 

  • Perry JD, Wolf H, Festenstein H, Storey GO (1979) Ankylosing hyperostosis: A study of HLA A, B and C antigens. Ann Rheum Dis 38: 72–73

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Riska EB, Michelsson JE (1979) Treatment of para-articular ossification after total hip replacement by excision and use of free fat transplants. Acta Orthop Scand 50: 751–754

    Article  CAS  PubMed  Google Scholar 

  • Scheidegger S (1939) Heterotope Knochenbildung (Beitrag zur Frage der Metaplasie). Schweiz Z Allg Pathol Bakteriol 2: 153–174

    CAS  Google Scholar 

  • Shapiro RF, Utsinger PD, Wiesner KB, Resnick D, Bryan BL, Castles JJ (1976) The association of HLA B27 with Forestier’s disease (vertebral ankylosing hyperostosis). J Rheumatol 3: 4–8

    CAS  PubMed  Google Scholar 

  • Spadaro JA (1977) Electrically stimulated bone growth in animals and man. Clin Orthop 122:325–332

    PubMed  Google Scholar 

  • Tama L (1966) Heterotopic bone formation in abdominal surgical scars. A report of two cases in brothers. JAMA 197: 219–221

    Article  CAS  PubMed  Google Scholar 

  • Tanner JM, Whitehouse RH, Hughes PCR, Vince FP (1971) Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children, with growth hormone deficiency, low birth weight, inherited smallness, Turner’s syndrome and other complaints. Arch Dis Child 46: 745–782

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Tredget T, Godberson CV, Bose B (1977) Myositis ossificans due to hockey injury. Can Med Assoc J 116: 65–66

    CAS  PubMed Central  PubMed  Google Scholar 

  • Weiss S, Grosswasser Z, Ohri A, Mizrahi Y, Orgad S, Efter T, Gazit E (1979) Histocompatibility (HLA) antigens in heterotopic ossification associated with neurological injury. J Rheumatol 6: 88–91

    CAS  PubMed  Google Scholar 

  • Zachmann M, Ferrandez A, MĂĽrset G, Prader A (1975) Estrogen treatment of excessively tall girls. Helv Paediatr Acta 30: 11–30

    CAS  PubMed  Google Scholar 

  • Zachmann M, Ferrandez A, MĂĽrset G, Gnehm HE, Prader A (1976) Testosterone treatment of excessively tall boys. J Pediatr 88: 116–123

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, Scotland

    J. M. Connor BSc, MB, ChB, MD, MRCP (Consultant in Medical Genetics)

Authors
  1. J. M. Connor BSc, MB, ChB, MD, MRCP
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Connor, J.M. (1983). Conclusions and Clinical Implications. In: Soft Tissue Ossification. Springer, London. https://doi.org/10.1007/978-1-4471-1343-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1343-0_9

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1345-4

  • Online ISBN: 978-1-4471-1343-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation