Abstract
A new disease, severe atypical respiratory syndrome (SARS), emerged in China in late 2002 and developed into the first epidemic of the 21st century. The disease was caused by an unknown animal coronavirus (CoV) that had crossed the species barrier through close contact of humans with infected animals, and was identified as the etiological agent for SARS. This new CoV not only became readily transmissible between humans but also was also more pathogenic. The disease spread across the world rapidly due to the air travel, and infected 8096 people and caused 774 deaths in 26 countries on 5 continents. The disease is characterized by flu-like symptoms, including high fever, malaise, cough, diarrhea, and infiltrates visible on chest radiography. The overall mortality was about 10%, but varied profoundly with age; the course of disease seemed to be milder in the pediatric age group and resulted rarely in a fatal outcome, but the mortality in the elderly was as high as 50%. Aggressive quarantine measures taken by the health authorities have successfully contained and terminated the disease transmission. As a result there are no SARS cases recorded recently. Nevertheless there is a possibility that the disease may emerge in the population with high vigor. Significant progress has been made in understanding the disease biology, pathogenesis, development of animal models, and design and evaluation of different vaccines, and these are the focus of this chapter.
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Keywords
- Severe Acute Respiratory Syndrome
- Infectious Bronchitis Virus
- Fusion Peptide
- Mouse Hepatitis Virus
- Replicase Gene
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Peiris, J.S., Lai, S.T., Poon, L.L., Guan, Y., Yam, L.Y., Lim, W., Nicholls, J., Yee, W.K., Yan, W.W., Cheung, M.T., Cheng, V.C., Chan, K.H., Tsang, D.N., Yung, R.W., Ng, T.K., and Yuen, K.Y. 2003, Lancet, 361, 1319.
Donnelly, C.A., Ghani, A.C., Leung, G.M., Hedley, A.J., Fraser, C., Riley, S., Abu-Raddad, L.J., Ho, L.M., Thach, T.Q., Chau, P., Chan, K.P., Lam, T.H., Tse, L.Y., Tsang, T., Liu, S.H., Kong, J.H., Lau, E.M., Ferguson, N.M., and Anderson, R.M. 2003, Lancet, 361, 1761.
Hon, K.L., Leung, C.W., Cheng, W.T., Chan, P.K., Chu, W.C., Kwan, Y.W., Li, A.M., Fong, N.C., Ng, P.C., Chiu, M.C., Li, C.K., Tam, J.S., and Fok, T.F. 2003, Lancet, 361, 1701.
Peiris, J.S., Chu, C.M., Cheng, V.C., Chan, K.S., Hung, I.F., Poon, L.L., Law, K.I., Tang, B.S., Hon, T.Y., Chan, C.S., Chan, K.H., Ng, J.S., Zheng, B.J., Ng, W.L., Lai, R.W., Guan, Y., and Yuen, K.Y. 2003, Lancet, 361, 1767.
Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R.A., Berger, A., Burguiere, A.M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J.C., Muller, S., Rickerts, V., Sturmer, M., Vieth, S., Klenk, H.D., Osterhaus, A.D., Schmitz, H., and Doerr, H.W. 2003, N. Engl. J. Med., 348, 1967.
Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., Tong, S., Urbani, C., Comer, J.A., Lim, W., Rollin, P.E., Dowell, S.F., Ling, A.E., Humphrey, C.D., Shieh, W.J., Guarner, J., Paddock, C.D., Rota, P., Fields, B., DeRisi, J., Yang, J.Y., Cox, N., Hughes, J.M., LeDuc, J.W., Bellini, W.J., and Anderson, L.J. 2003, N. Engl. J. Med., 348, 1953.
Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Somasundaran, M., Sullivan, J.L., Luzuriaga, K., Greenough, T.C., Choe, H., and Farzan, M. 2003, Nature, 426, 450.
Fouchier, R.A., Kuiken, T., Schutten, M., Van Amerongen, G., Van Doornum, G.J., Van Den Hoogen, B.G., Peiris, M., Lim, W., Stohr, K., and Osterhaus, A.D. 2003, Nature, 423, 240.
Pearson, H., Clarke, T., Abbott, A., Knight, J., and Cyranoski, D. 2003, Nature, 424, 121.
WHO 2004, Update 3: Announcement of suspected SARS case in southern China; Investigation of source of infection for confirmed case begins tomorrow.
Snijder, E.J., Bredenbeek, P.J., Dobbe, J.C., Thiel, V., Ziebuhr, J., Poon, L.L., Guan, Y., Rozanov, M., Spaan, W.J., and Gorbalenya, A.E. 2003, J. Mol. Biol., 331, 991.
Ruan, Y.J., Wei, C.L., Ee, L.A., Vega, V.B., Thoreau, H., Yun, S.T.S., Chia, J.M., Ng, P., Chiu, K.P., Lim, L., Tao, Z., Peng, C.K., Ean, L.O.L.E., Lee, N.M., Sin, L.Y., Ng, L.F.P., Chee, R.e., Stanton, L.W., Long, P.M., and Liu, E.T. 2003, Lancet, 361, 1779.
Guan, Y., Zheng, B.J., He, Y.Q., Liu, X.L., Zhuang, Z.X., Cheung, C.L., Luo, S.W., Li, P.H., Zhang, L.J., Guan, Y.J., Butt, K.M., Wong, K.L., Chan, K.W., Lim, W., Shortridge, K.F., Yuen, K.Y., Peiris, J.S., and Poon, L.L. 2003, Science, 302, 276.
Martina, B.E., Haagmans, B.L., Kuiken, T., Fouchier, R.A., Rimmelzwaan, G.F., Van Amerongen, G., Peiris, J.S., Lim, W., and Osterhaus, A.D. 2003, Nature, 425, 915.
WHO. 2003, Wkly. Epidemiol. Rec., 78, 86.
Marra, M.A., Jones, S.J., Astell, C.R., Holt, R.A., Brooks-Wilson, A., Butterfield, Y.S., Khattra, J., Asano, J.K., Barber, S.A., Chan, S.Y., Cloutier, A., Coughlin, S.M., Freeman, D., Girn, N., Griffith, O.L., Leach, S.R., Mayo, M., McDonald, H., Montgomery, S.B., Pandoh, P.K., Petrescu, A.S., Robertson, A.G., Schein, J.E., Siddiqui, A., Smailus, D.E., Stott, J.M., Yang, G.S., Plummer, F., Andonov, A., Artsob, H., Bastien, N., Bernard, K., Booth, T.F., Bowness, D., Czub, M., Drebot, M., Fernando, L., Flick, R., Garbutt, M., Gray, M., Grolla, A., Jones, S., Feldmann, H., Meyers, A., Kabani, A., Li, Y., Normand, S., Stroher, U., Tipples, G.A., Tyler, S., Vogrig, R., Ward, D., Watson, B., Brunham, R.C., Krajden, M., Petric, M., Skowronski, D.M., Upton, C., and Roper, R.L. 2003, Science, 300, 1399.
Rota, P.A., Oberste, M.S., Monroe, S.S., Nix, W.A., Campagnoli, R., Icenogle, J.P., Penaranda, S., Bankamp, B., Maher, K., Chen, M.H., Tong, S., Tamin, A., Lowe, L., Frace, M., DeRisi, J.L., Chen, Q., Wang, D., Erdman, D.D., Peret, T.C., Burns, C., Ksiazek, T.G., Rollin, P.E., Sanchez, A., Liffick, S., Holloway, B., Limor, J., McCaustland, K., Olsen-Rasmussen, M., Fouchier, R., Gunther, S., Osterhaus, A.D., Drosten, C., Pallansch, M.A., Anderson, L.J., and Bellini, W.J. 2003, Science, 300, 1394.
Holmes, K.V. 2003, N. Engl. J. Med., 348, 1948.
Eickmann, M., Becker, S., Klenk, H.D., Doerr, H.W., Stadler, K., Censini, S., Guidotti, S., Masignani, V., Scarselli, M., Mora, M., Donati, C., Han, J., Song, H.C., Abrignani, S., Covacci, A., and Rappuoli, R. 2003, Science, 302, 1504.
Eickmann, M., Becker, S., Klenk, H.D., Doerr, H.W., Stadler, K., Censini, S., Guidotti, S., Masignani, V., Scarselli, M., Mora, M., Donati, C., Han, J.H., Song, H.C., Abrignani, S., Covacci, A., and Rappuoli, R. 2003, Science, 302, 1504.
Xiao, X., Chakraborti, S., Dimitrov, A.S., Gramatikoff, K., and Dimitrov, D.S. 2003, Biochem. Biophys. Res. Commun., 312, 1159.
Wang, P., Chen, J., Zheng, A., Nie, Y., Shi, X., Wang, W., Wang, G., Luo, M., Liu, H., Tan, L., Song, X., Wang, Z., Yin, X., Qu, X., Wang, X., Qing, T., Ding, M., and Deng, H. 2004, Biochem. Biophys. Res. Commun., 315, 439.
WHO 2003, Consultation on needs and opportunities for SARS vaccine research and development.
Bosch, B.J., van der Zee, R., de Haan, C.A., and Rottier, P.J. 2003, J. Virol., 77, 8801.
Dimitrov, D.S. 2003, Cell., 115, 652.
Prabakaran, P., Xiao, X., and Dimitrov, D.S. 2004, Biochem. Biophys. Res. Commun., 314, 235.
Babcock, G.J., Esshaki, D.J., Thomas, W.D., Jr., and Ambrosino, D.M. 2004, J. Virol., 78, 4552.
Wong, S.K., Li, W., Moore, M.J., Choe, H., and Farzan, M. 2004, J. Biol. Chem., 279, 3197.
Xiang, S.H., Wang, L., Abreu, M., Huang, C.C., Kwong, P.D., Rosenberg, E., Robinson, J.E., and Sodroski, J. 2003, Virology, 315, 124.
Liu, S., Xiao, G., Chen, Y., He, Y., Niu, J., Escalante, C.R., Xiong, H., Farmar, J., Debnath, A.K., Tien, P., and Jiang, S. 2004, Lancet, 363, 938.
Tripet, B., Howard, M.W., Jobling, M., Holmes, R.K., Holmes, K.V., and Hodges, R.S. 2004, J Biol Chem., 279, 20836.
Chan, D.C., Fass, D., Berger, J.M., and Kim, P.S. 1997, Cell, 89, 263.
Xu, Y., Liu, Y.J., and Yu, Q. 2004, J. Biol. Chem., 279, 41179.
Delmas, B., and Laude, H. 1990, J. Virol., 64, 5367.
Wiley, D.C., Skehel, J.J., and Waterfield, M. 1977, Virology, 79, 446.
Wyatt, R., Kwong, P.D., Desjardins, E., Sweet, R.W., Robinson, J., Hendrickson, W.A., and Sodroski, J.G. 1998, Nature, 393, 705.
Doms, R.W., Keller, D.S., Helenius, A., and Balch, W.E. 1987, J. Cell Biol., 105, 1957.
Li, F., Li, W., Farzan, M., and Harrison, S.C. 2006, Adv. Exp. Med. Biol., 581, 229.
van Kooyk, Y., and Geijtenbeek, T.B. 2003, Nat. Rev. Immunol., 3, 697.
Marzi, A., Gramberg, T., Simmons, G., Moller, P., Rennekamp, A.J., Krumbiegel, M., Geier, M., Eisemann, J., Turza, N., Saunier, B., Steinkasserer, A., Becker, S., Bates, P., Hofmann, H., and Pohlmann, S. 2004, J. Virol., 78, 12090.
Yang, Z.Y., Huang, Y., Ganesh, L., Leung, K., Kong, W.P., Schwartz, O., Subbarao, K., and Nabel, G.J. 2004, J. Virol., 78, 5642.
Towler, P., Staker, B., Prasad, S.G., Menon, S., Tang, J., Parsons, T., Ryan, D., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., and Pantoliano, M.W. 2004, J. Biol. Chem., 279, 17996.
Hofmann, H., Geier, M., Marzi, A., Krumbiegel, M., Peipp, M., Fey, G.H., Gramberg, T., and Pohlmann, S. 2004, Biochem. Biophys. Res. Commun., 319, 1216.
Kuiken, T., Fouchier, R.A., Schutten, M., Rimmelzwaan, G.F., van Amerongen, G., van Riel, D., Laman, J.D., de Jong, T., van Doornum, G., Lim, W., Ling, A.E., Chan, P.K., Tam, J.S., Zambon, M.C., Gopal, R., Drosten, C., van der Werf, S., Escriou, N., Manuguerra, J.C., Stohr, K., Peiris, J.S., and Osterhaus, A.D. 2003, Lancet, 362, 263.
Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., and Murphy, B. 2004, J. Virol., 78, 3572.
Tipnis, S.R., Hooper, N.M., Hyde, R., Karran, E., Christie, G., and Turner, A.J. 2000, J. Biol. Chem., 275, 33238.
Crackower, M.A., Sarao, R., Oudit, G.Y., Yagil, C., Kozieradzki, I., Scanga, S.E., Oliveira-dos-Santos, A.J., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, C.M., Manoukian, A.S., Chappell, M.C., Backx, P.H., Yagil, Y., and Penninger, J.M. 2002, Nature, 417, 822.
Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., and van Goor, H. 2004, J. Pathol., 203, 631.
Ding, Y., Wang, H., Shen, H., Li, Z., Geng, J., Han, H., Cai, J., Li, X., Kang, W., Weng, D., Lu, Y., Wu, D., He, L., and Yao, K. 2003, J. Pathol., 200, 282.
Nicholls, J.M., Poon, L.L., Lee, K.C., Ng, W.F., Lai, S.T., Leung, C.Y., Chu, C.M., Hui, P.K., Mak, K.L., Lim, W., Yan, K.W., Chan, K.H., Tsang, N.C., Guan, Y., Yuen, K.Y., and Peiris, J.S. 2003, Lancet, 361, 1773.
To, K.F., Tong, J.H., Chan, P.K., Au, F.W., Chim, S.S., Chan, K.C., Cheung, J.L., Liu, E.Y., Tse, G.M., Lo, A.W., Lo, Y.M., and Ng, H.K. 2004, J. Pathol., 202, 157.
Leung, W.K., To, K.F., Chan, P.K., Chan, H.L., Wu, A.K., Lee, N., Yuen, K.Y., and Sung, J.J. 2003, Gastroenterology, 125, 1011.
Lew, T.W., Kwek, T.K., Tai, D., Earnest, A., Loo, S., Singh, K., Kwan, K.M., Chan, Y., Yim, C.F., Bek, S.L., Kor, A.C., Yap, W.S., Chelliah, Y.R., Lai, Y.C., and Goh, S.K. 2003, JAMA, 290, 374.
Hofmann, H., Hattermann, K., Marzi, A., Gramberg, T., Geier, M., Krumbiegel, M., Kuate, S., Uberla, K., Niedrig, M., and Pohlmann, S. 2004, J. Virol., 78, 6134.
Smith, A.E., and Helenius, A. 2004, Science, 304, 237.
Simmons, G., Reeves, J.D., Rennekamp, A.J., Amberg, S.M., Piefer, A.J., and Bates, P. 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 4240.
de Haan, C.A., Stadler, K., Godeke, G.J., Bosch, B.J., and Rottier, P.J. 2004, J. Virol., 78, 6048.
Bisht, H., Roberts, A., Vogel, L., Bukreyev, A., Collins, P.L., Murphy, B.R., Subbarao, K., and Moss, B. 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 6641.
Eckert, D.M., and Kim, P.S. 2001, Annu. Rev. Biochem., 70, 777.
Kilby, J.M., and Eron, J.J. 2003, N. Engl. J. Med., 348, 2228.
Huang, Q., Yu, L., Petros, A.M., Gunasekera, A., Liu, Z., Xu, N., Hajduk, P., Mack, J., Fesik, S.W., and Olejniczak, E.T. 2004, Biochemistry (Mosc). 43, 6059.
Boots, A.M., Kusters, J.G., van Noort, J.M., Zwaagstra, K.A., Rijke, E., van der Zeijst, B.A., and Hensen, E.J. 1991, Immunology, 74, 8.
Bergmann, C., McMillan, M., and Stohlman, S. 1993, J. Virol., 67, 7041.
Thiel, V., Ivanov, K.A., Putics, A., Hertzig, T., Schelle, B., Bayer, S., Weissbrich, B., Snijder, E.J., Rabenau, H., Doerr, H.W., Gorbalenya, A.E., and Ziebuhr, J. 2003, J. Gen. Virol., 84, 2305.
Yang, Z.Y., Wyatt, L.S., Kong, W.P., Moodie, Z., Moss, B., and Nabel, G.J. 2003, J. Virol., 77, 799.
Ziebuhr, J. 2004, Curr. Opin. Microbiol., 7, 412.
Yang, Z.Y., Kong, W.P., Huang, Y., Roberts, A., Murphy, B.R., Subbarao, K., and Nabel, G.J. 2004, Nature, 428, 561.
Buchholz, U.J., Bukreyev, A., Yang, L., Lamirande, E.W., Murphy, B.R., Subbarao, K., and Collins, P.L. 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 9804.
Gao, W., Tamin, A., Soloff, A., D’Aiuto, L., Nwanegbo, E., Robbins, P.D., Bellini, W.J., Barratt-Boyes, S., and Gambotto, A. 2003, Lancet, 362, 1895.
Li, G., Chen, X., and Xu, A. 2003, N. Engl. J. Med., 349, 508.
Wang, Y.D., Li, Y., Xu, G.B., Dong, X.Y., Yang, X.A., Feng, Z.R., Tian, C., and Chen, W.F. 2004, Clin. Immunol., 113, 145.
Soo, Y.O., Cheng, Y., Wong, R., Hui, D.S., Lee, C.K., Tsang, K.K., Ng, M.H., Chan, P., Cheng, G., and Sung, J.J. 2004, Clin. Microbiol. Infect., 10, 676.
Keller, M.A., and Stiehm, E.R. 2000, Clin. Microbiol. Rev., 13, 602.
Sui, J., Li, W., Murakami, A., Tamin, A., Matthews, L.J., Wong, S.K., Moore, M.J., Tallarico, A.S., Olurinde, M., Choe, H., Anderson, L.J., Bellini, W.J., Farzan, M., and Marasco, W.A. 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 2536.
ter Meulen, J., Bakker, A.B., van den Brink, E.N., Weverling, G.J., Martina, B.E., Haagmans, B.L., Kuiken, T., de Kruif, J., Preiser, W., Spaan, W., Gelderblom, H.R., Goudsmit, J., and Osterhaus, A.D. 2004, Lancet, 363, 2139.
Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M.R., Murphy, B.R., Rappuoli, R., and Lanzavecchia, A. 2004, Nat. Med., 10, 871.
Yang, L.T., Peng, H., Zhu, Z.L., Li, G., Huang, Z.T., Zhao, Z.X., Koup, R.A., Bailer, R.T., and Wu, C.Y. 2006, Clin. Immunol., 120, 171.
Rowe, T., Gao, G., Hogan, R.J., Crystal, R.G., Voss, T.G., Grant, R.L., Bell, P., Kobinger, G.P., Wivel, N.A., and Wilson, J.M. 2004, J Virol, 78, 11401.
McAuliffe, J., Vogel, L., Roberts, A., Fahle, G., Fischer, S., Shieh, W.J., Butler, E., Zaki, S., St Claire, M., Murphy, B., and Subbarao, K. 2004, Virology, 330, 8.
Roberts, A., Kretzschmar, E., Perkins, A.S., Forman, J., Price, R., Buonocore, L., Kawaoka, Y., and Rose, J.K. 1998, J. Virol., 72, 4704.
Ladman, B.S., Pope, C.R., Ziegler, A.F., Swieczkowski, T., Callahan, C.J., Davison, S., and Gelb, J., Jr. 2002, Avian Dis., 46, 938.
Pratelli, A., Tinelli, A., Decaro, N., Martella, V., Camero, M., Tempesta, M., Martini, M., Carmichael, L.E., and Buonavoglia, C. 2004, Vet. Microbiol., 99, 43.
Zhou, J., Wang, W., Zhong, Q., Hou, W., Yang, Z., Xiao, S.Y., Zhu, R., Tang, Z., Wang, Y., Xian, Q., Tang, H., and Wen, L. 2005, Vaccine, 23, 3202.
He, Y., Zhou, Y., Siddiqui, P., and Jiang, S. 2004, Biochem. Biophys. Res. Commun., 325, 445.
Stadler, K., Roberts, A., Becker, S., Vogel, L., Eickmann, M., Kolesnikova, L., Klenk, H.D., Murphy, B., Rappuoli, R., Abrignani, S., and Subbarao, K. 2005, Emerg. Infect. Dis., 11, 1312.
Podda, A., Del Giudice, G. 2004, New Generation Vaccines, M. Levine, Kaper, J.B., Rappuoli, R., Liu, M., Good, M.F. (Ed.), Marcel Dekker, New York, 225.
Takasuka, N., Fujii, H., Takahashi, Y., Kasai, M., Morikawa, S., Itamura, S., Ishii, K., Sakaguchi, M., Ohnishi, K., Ohshima, M., Hashimoto, S., Odagiri, T., Tashiro, M., Yoshikura, H., Takemori, T., and Tsunetsugu-Yokota, Y. 2004, Int. Immunol., 16, 1423.
Tang, L., Zhu, Q., Qin, E., Yu, M., Ding, Z., Shi, H., Cheng, X., Wang, C., Chang, G., Fang, F., Chang, H., Li, S., Zhang, X., Chen, X., Yu, J., Wang, J., and Chen, Z. 2004, DNA Cell Biol., 23, 391.
Zhang, C.H., Lu, J.H., Wang, Y.F., Zheng, H.Y., Xiong, S., Zhang, M.Y., Liu, X.J., Li, J.X., Wan, Z.Y., Yan, X.G., Qi, S.Y., Cui, Z., and Zhang, B. 2005, Vaccine, 23, 3196.
Purcell, R.H., D’Hondt, E., Bradbury, R., Emerson, S.U., Govindarajan, S., and Binn, L. 1992, Vaccine, 10 Suppl 1, S148.
Sauzet, J.P., Perlaza, B.L., Brahimi, K., Daubersies, P., and Druilhe, P. 2001, Infect. Immun., 69, 1202.
Sedegah, M., Weiss, W., Sacci, J.B., Jr., Charoenvit, Y., Hedstrom, R., Gowda, K., Majam, V.F., Tine, J., Kumar, S., Hobart, P., and Hoffman, S.L. 2000, J. Immunol., 164, 5905.
Ulmer, J.B., Donnelly, J.J., Parker, S.E., Rhodes, G.H., Felgner, P.L., Dwarki, V.J., Gromkowski, S.H., Deck, R.R., DeWitt, C.M., Friedman, A., et al. 1993, Science, 259, 1745.
Robinson, H.L., and Torres, C.A. 1997, Semin. Immunol., 9, 271.
Jin, H., Xiao, C., Chen, Z., Kang, Y., Ma, Y., Zhu, K., Xie, Q., Tu, Y., Yu, Y., and Wang, B. 2005, Biochem. Biophys. Res. Commun., 328, 979.
Dunachie, S.J., and Hill, A.V. 2003, J. Exp. Biol., 206, 3771.
McShane, H., Brookes, R., Gilbert, S.C., and Hill, A.V. 2001, Infect. Immun., 69, 681.
Zhu, M.S., Pan, Y., Chen, H.Q., Shen, Y., Wang, X.C., Sun, Y.J., and Tao, K.H. 2004, Immunol. Lett., 92, 237.
Kim, T.W., Lee, J.H., Hung, C.F., Peng, S., Roden, R., Wang, M.C., Viscidi, R., Tsai, Y.C., He, L., Chen, P.J., Boyd, D.A., and Wu, T.C. 2004, J. Virol., 78, 4638.
Shi, S.Q., Peng, J.P., Li, Y.C., Qin, C., Liang, G.D., Xu, L., Yang, Y., Wang, J.L., and Sun, Q.H. 2006, Mol. Immunol., 43, 1791.
Huang, J., Ma, R., and Wu, C.Y. 2006, Vaccine, 24, 4905.
Woo, P.C., Lau, S.K., Tsoi, H.W., Chen, Z.W., Wong, B.H., Zhang, L., Chan, J.K., Wong, L.P., He, W., Ma, C., Chan, K.H., Ho, D.D., and Yuen, K.Y. 2005, Vaccine, 23, 4959.
Zhang, M.Y., Xiao, X., Sidorov, I.A., Choudhry, V., Cham, F., Zhang, P.F., Bouma, P., Zwick, M., Choudhary, A., Montefiori, D.C., Broder, C.C., Burton, D.R., Quinnan, G.V., Jr., and Dimitrov, D.S. 2004, J. Virol., 78, 9233.
Song, H.C., Seo, M.Y., Stadler, K., Yoo, B.J., Choo, Q.L., Coates, S.R., Uematsu, Y., Harada, T., Greer, C.E., Polo, J.M., Pileri, P., Eickmann, M., Rappuoli, R., Abrignani, S., Houghton, M., and Han, J.H. 2004, J. Virol., 78, 10328.
Olsen, C.W., Corapi, W.V., Ngichabe, C.K., Baines, J.D., and Scott, F.W. 1992, J. Virol., 66, 956.
Yang, Z.Y., Werner, H.C., Kong, W.P., Leung, K., Traggiai, E., Lanzavecchia, A., and Nabel, G.J. 2005, Proc. Natl. Acad. Sci. U. S. A., 102, 797.
Zakhartchouk, A.N., Liu, Q., Petric, M., and Babiuk, L.A. 2005, Vaccine, 23, 4385.
Sin, J.I., Bagarazzi, M., Pachuk, C., and Weiner, D.B. 1999, DNA Cell Biol., 18, 771.
Ioannou, X.P., Gomis, S.M., Karvonen, B., Hecker, R., Babiuk, L.A., and van Drunen Littel-van den Hurk, S. 2002, Vaccine, 21, 127.
Du, L., He, Y., Wang, Y., Zhang, H., Ma, S., Wong, C.K., Wu, S.H., Ng, F., Huang, J.D., Yuen, K.Y., Jiang, S., Zhou, Y., and Zheng, B.J. 2006, Virology, 353, 6.
Monahan, P.E., and Samulski, R.J. 2000, Mol. Med. Today, 6, 433.
Rabinowitz, J.E., and Samulski, J. 1998, Curr. Opin. Biotechnol., 9, 470.
Smith-Arica, J.R., and Bartlett, J.S. 2001, Curr. Cardiol. Rep., 3, 43.
Muruve, D.A. 2004, Hum. Gene Ther., 15, 1157.
Nasz, I., and Adam, E. 2001, Acta Microbiol. Immunol. Hung., 48, 323.
Foley, H.D., McGettigan, J.P., Siler, C.A., Dietzschold, B., and Schnell, M.J. 2000, Proc. Natl. Acad. Sci. U. S. A., 97, 14680.
Foley, H.D., Otero, M., Orenstein, J.M., Pomerantz, R.J., and Schnell, M.J. 2002, J. Virol., 76, 19.
McGettigan, J.P., Sarma, S., Orenstein, J.M., Pomerantz, R.J., and Schnell, M.J. 2001, J. Virol., 75, 8724.
McGettigan, J.P., Naper, K., Orenstein, J., Koser, M., McKenna, P.M., and Schnell, M.J. 2003, J. Virol., 77, 10889.
Morimoto, K., Schnell, M.J., Pulmanausahakul, R., McGettigan, J.P., Foley, H.D., Faber, M., Hooper, D.C., and Dietzschold, B. 2001, J. Immunol. Methods, 252, 199.
Schnell, M.J., Foley, H.D., Siler, C.A., McGettigan, J.P., Dietzschold, B., and Pomerantz, R.J. 2000, Proc. Natl. Acad. Sci. U. S. A., 97, 3544.
Siler, C.A., McGettigan, J.P., Dietzschold, B., Herrine, S.K., Dubuisson, J., Pomerantz, R.J., and Schnell, M.J. 2002, Virology, 292, 24.
Faber, M., Lamirande, E.W., Roberts, A., Rice, A.B., Koprowski, H., Dietzschold, B., and Schnell, M.J. 2005, J. Gen. Virol., 86, 1435.
Schnell, M.J., Mebatsion, T., and Conzelmann, K.K. 1994, EMBO J., 13, 4195.
Orciari, L.A., Niezgoda, M., Hanlon, C.A., Shaddock, J.H., Sanderlin, D.W., Yager, P.A., and Rupprecht, C.E. 2001, Vaccine, 19, 4511.
Dietzschold, B., Faber, M., and Schnell, M.J. 2003, Expert. Rev. Vaccine, 2, 399.
Shoji, Y., Kobayashi, Y., Sato, G., Itou, T., Miura, Y., Mikami, T., Cunha, E.M., Samara, S.I., Carvalho, A.A., Nocitti, D.P., Ito, F.H., Kurane, I., and Sakai, T. 2004, J. Vet. Med. Sci., 66, 1271.
Lafon, M., Lafage, M., Martinez-Arends, A., Ramirez, R., Vuillier, F., Charron, D., Lotteau, V., and Scott-Algara, D. 1992, Nature, 358, 507.
Zhi, Y., Figueredo, J., Kobinger, G.P., Hagan, H., Calcedo, R., Miller, J.R., Gao, G., and Wilson, J.M. 2006, Hum. Gene Ther., 17, 500.
Ba, L., Yi, C.E., Zhang, L., Ho, D.D., and Chen, Z. 2007, Appl. Microbiol. Biotechnol., 76, 1131.
Ishii, K., Hasegawa, H., Nagata, N., Mizutani, T., Morikawa, S., Suzuki, T., Taguchi, F., Tashiro, M., Takemori, T., Miyamura, T., and Tsunetsugu-Yokota, Y. 2006, Virology, 351, 368.
Ishii, K., Hasegawa, H., Nagata, N., Mizutani, T., Morikawa, S., Tashiro, M., Suzuki, T., Taguchi, F., Takemori, T., Miyamura, T., and Tsunetsugu-Yokota, Y. 2006, Adv. Exp. Med. Biol., 581, 593.
Sui, J., Li, W., Roberts, A., Matthews, L.J., Murakami, A., Vogel, L., Wong, S.K., Subbarao, K., Farzan, M., and Marasco, W.A. 2005, J. Virol., 79, 5900.
van den Brink, E.N., Ter Meulen, J., Cox, F., Jongeneelen, M.A., Thijsse, A., Throsby, M., Marissen, W.E., Rood, P.M., Bakker, A.B., Gelderblom, H.R., Martina, B.E., Osterhaus, A.D., Preiser, W., Doerr, H.W., de Kruif, J., and Goudsmit, J. 2005, J. Virol., 79, 1635.
He, Y., Li, J., Du, L., Yan, X., Hu, G., Zhou, Y., and Jiang, S. 2006, Vaccine, 24, 5498.
Bisht, H., Roberts, A., Vogel, L., Subbarao, K., and Moss, B. 2005, Virology, 334, 160.
He, Y., Li, J., and Jiang, S. 2006, Biochem. Biophys. Res. Commun., 344, 106.
Bai, B., Lu, X., Meng, J., Hu, Q., Mao, P., Lu, B., Chen, Z., Yuan, Z., and Wang, H. 2008, Mol. Immunol., 45, 868.
Chang, C.Y., Hong, W.W., Chong, P., and Wu, S.C. 2006, Vaccine, 24, 1132.
Gorbalenya, A.E., Snijder, E.J., and Spaan, W.J. 2004, J. Virol., 78, 7863.
Ho, Y., Lin, P.H., Liu, C.Y., Lee, S.P., and Chao, Y.C. 2004, Biochem. Biophys. Res. Commun., 318, 833.
Mortola, E., and Roy, P. 2004, FEBS Lett., 576, 174.
Huang, Y., Yang, Z.Y., Kong, W.P., and Nabel, G.J. 2004, J. Virol., 78, 12557.
Richmond, J.F., Lu, S., Santoro, J.C., Weng, J., Hu, S.L., Montefiori, D.C., and Robinson, H.L. 1998, J. Virol., 72, p9092.
VanCott, T.C., Mascola, J.R., Kaminski, R.W., Kalyanaraman, V., Hallberg, P.L., Burnett, P.R., Ulrich, J.T., Rechtman, D.J., and Birx, D.L. 1997, J. Virol., 71, 4319.
Hu, H., Lu, X., Tao, L., Bai, B., Zhang, Z., Chen, Y., Zheng, F., Chen, J., Chen, Z., and Wang, H. 2007, Clin. Vaccine Immunol., 14, 894.
Vennema, H., de Groot, R.J., Harbour, D.A., Dalderup, M., Gruffydd-Jones, T., Horzinek, M.C., and Spaan, W.J. 1990, J. Virol., 64, 1407.
Stadler, K., and Rappuoli, R. 2005, Curr. Mol. Med., 5, 677.
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Srivastava, I.K., Kan, E., Srivastava, I.N., Cisto, J., Biron, Z. (2008). Structure, Immunopathogenesis and Vaccines Against SARS Coronavirus. In: Vajdy, M. (eds) Immunity Against Mucosal Pathogens. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8412-6_14
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