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The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir

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HIV-1 Latency

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 417))

Abstract

Latently infected resting memory CD4+ T cells represent a major barrier to HIV-1 eradication. Studies have shown that it will not be possible to cure HIV-1 infection unless these cells are eliminated. Latently infected cells probably do not express viral antigens and thus may not be susceptible to the HIV-1 specific immune response, nevertheless the size and composition of the reservoir is influenced by the immune system. In this chapter, we review the different components of the HIV-1 specific immune response and discuss how the immune system can be harnessed to eradicate the virus.

This work was supported by NIH grants (P30AI094189), 2R56AI080328-05A1 and 1R01AI120024-01.

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Authors and Affiliations

  1. Center for AIDS Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Rebecca T. Veenhuis & Joel N. Blankson

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  1. Rebecca T. Veenhuis
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  2. Joel N. Blankson
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Correspondence to Joel N. Blankson .

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  1. School of Medicine, Emory University, Atlanta, GA, USA

    Guido Silvestri

  2. The Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA

    Mathias Lichterfeld

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Veenhuis, R.T., Blankson, J.N. (2017). The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir. In: Silvestri, G., Lichterfeld, M. (eds) HIV-1 Latency. Current Topics in Microbiology and Immunology, vol 417. Springer, Cham. https://doi.org/10.1007/82_2017_72

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