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Behavioral Neurobiology of Psychedelic Drugs pp 313–332Cite as

Experimental Psychosis Research and Schizophrenia—Similarities and Dissimilarities in Psychopathology

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 36))

Abstract

The aim of experimental psychopathology is to delineate overlapping functional disorders of psychoneurobiologically-defined systems where a set of common symptoms may correspond to a variety of nosological entities. According to the vulnerability model of psychosis, experimental research needs to go beyond categories such as “schizophrenia”. Prospective studies of the effects of psychoactive substances in normal control subjects offer several methodological advantages over routine clinical reviews of schizophrenic patients, especially in terms of standardization. Carefully designed studies utilizing a model psychosis paradigm are a step toward symptom-oriented research. Combining psychological and neurobiological techniques, the experimental psychopathological approach can provide us with a valuable tool for psychiatric research.

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Author information

Authors and Affiliations

  1. Christophsbad, Klinik für Psychiatrie und Psychotherapie, Faurndauer Straße 6-28, D-73035, Göppingen, Germany

    Leo Hermle

  2. Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zurich, Lenggstrasse 31, P.O Box 1931, 8032, Zurich, Switzerland

    Rainer Kraehenmann

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  1. Leo Hermle
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  2. Rainer Kraehenmann
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Correspondence to Leo Hermle .

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Editors and Affiliations

  1. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    Adam L. Halberstadt

  2. Psychiatric University Hospital, Heffter Research Center Zurich, University of Zurich, Zurich, Switzerland

    Franz X. Vollenweider

  3. Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, NC, USA

    David E. Nichols

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Hermle, L., Kraehenmann, R. (2016). Experimental Psychosis Research and Schizophrenia—Similarities and Dissimilarities in Psychopathology. In: Halberstadt, A.L., Vollenweider, F.X., Nichols, D.E. (eds) Behavioral Neurobiology of Psychedelic Drugs. Current Topics in Behavioral Neurosciences, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2016_460

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