Biomatrices for Heart Regeneration and Cardiac Tissue Modelling In Vitro

Kulvinskiene, I.; Aldonyte, R.; Miksiunas, R.; Mobasheri, A.; Bironaite, Daiva

doi:10.1007/5584_2020_564

I. Kulvinskiene⁷,
R. Aldonyte⁷,
R. Miksiunas⁷,
A. Mobasheri^7,8,9 &
…
Daiva Bironaite⁷

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1298))

1099 Accesses
1 Citations

Abstract

Cardiac muscle is the hardest working muscle in the body, pumping approximately 70 g of blood with every heartbeat, circulating 9500 l of blood daily and contracting over 3 billion times during the average human’s life. Heart failure – a heterogeneous syndrome – is a major and increasing health care problem worldwide and a leading cause of hospitalization and morbidity in elderly. Adequate heart tissue regeneration in human is lacking. Challenges to engineer heart tissue and employ it in vitro or in regenerative medicine remain to be solved. First of all, cardiac tissue bioengineering requires robust and powerful cells capable of differentiating into cardiomyogenic lineages in combination with effective, safe and highly specialized biomaterials, hydrogels and/or scaffolds for recreating the native extracellular microenvironment. Advances in stem cell and biomaterial science already provided an increasing array of cell resources, their cultivation technologies and biomatrices for efficient and safe cardiac tissue reconstruction. In order to develop new cardiac tissue mimicking technologies in vitro, it is necessary to analyze the advantages and drawbacks of already established biosystems. Therefore, in this paper, we provide a comprehensive overview of recently employed cells, 2D and 3D biomatrices for cardiac tissue engineering and review the current state-of-the-art in this field as well as future directions.

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Abbreviations

ADSC:: adipose tissue-derived stem cells
AuNRs:: albumin electrospun fibers and gold nanorods
BMP4:: bone morphogenetic protein 4
CDC:: cardiosphere-derived cells
CM:: cardiomyocytes
CNT:: carbon nanotubes
CPCs:: cardiac progenitor cells
CPS:: cardio progenitor spheres
CVD:: cardiovascular diseases
EBs:: embryonic bodies
ECM:: extracellular matrix
ESCs:: embryonic stem cells
GAG:: glycosaminoglycan
G-CSF:: granulocyte colony-stimulating factor
GSK3:: glycogen synthase kinase 3
HF:: heart failure
hFFs:: human foreskin fibroblasts
HGF:: hepatocyte growth factor
IC:: intracoronary infusion
IGF-1:: insulin-like growth factor
IM:: intramyocardially
iPSC:: induced pluripotent stem cells
LVEF:: left ventricular ejection fraction
MEF:: mouse embryonic fibroblast
MRI:: magnetic resonance imaging
MSC:: mesenchymal stem/stromal cells
Nrg:: Neuregulin-1
PCL:: polyɛ-caprolactone
PCL:: poly-ε-caprolactone
PDGFRα:: platelet-derived growth factor receptor-alpha
PFHy:: polyethylene glycol-fibrinogen hydrogel
PGA:: poly(glycolic acid) or poly-glycolide
pHLIP:: pH low insertion peptide
PIPAAm:: poly N-isopropylacrylamide
PLA:: poly-lactic acid
PSC:: pluripotent stem cells
RCVI:: retrograde coronary venous infusion
Sca − 1:: stem cell antigen-1
SDF-1:: stromal-derived growth factor 1
TESI:: transendocardial injection
TGF-β:: transforming growth factor β
VEGF:: vascular endothelial growth factor

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Acknowledgements

This work was supported by the project: Studies of the regenerative potential and mechanoptosis of the human heart primary cardiospheres, (No. S-MIP-17-13).

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Authors and Affiliations

Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
I. Kulvinskiene, R. Aldonyte, R. Miksiunas, A. Mobasheri & Daiva Bironaite
Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine University of Oulu, Oulu, Finland
A. Mobasheri
Department of Orthopedics and Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
A. Mobasheri

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I. Kulvinskiene
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R. Aldonyte
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R. Miksiunas
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A. Mobasheri
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Daiva Bironaite
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Correspondence to Daiva Bironaite .

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Ottawa Hospital Research Institute, Ottawa, ON, Canada
Kursad Turksen

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Kulvinskiene, I., Aldonyte, R., Miksiunas, R., Mobasheri, A., Bironaite, D. (2020). Biomatrices for Heart Regeneration and Cardiac Tissue Modelling In Vitro. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 10. Advances in Experimental Medicine and Biology(), vol 1298. Springer, Cham. https://doi.org/10.1007/5584_2020_564

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DOI: https://doi.org/10.1007/5584_2020_564
Published: 27 June 2020
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-60011-2
Online ISBN: 978-3-030-60012-9
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