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Potential of Tribological Properties of Metal Nanomaterials in Biomedical Applications

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Book cover Cell Biology and Translational Medicine, Volume 7

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1237))

Abstract

Metallic nanomaterials show tremendous applications in biomedical devices due to compatible integration into the most of the biological systems as they are nano- structured. Metallic nanomaterials are capable of mimicking all the three major antioxidant enzymes such as catalase (CAT), peroxidase and oxidase, to control the level of reactive oxygen species (ROS) inside the cell as an alternative strategy over conventional one which has biological toxicity and have several adverse effects, if accumulation takes places during the treatment. This anti-oxidant property of metallic nanomaterials demonstrates as a promising candidate for its biomedical application in disease conditions where the excessive level of ROS causes damage to DNA, lipids and protein in several conditions such as diabetes, cancer and neurodegenerative diseases. Tribology is the study of interacting surfaces in motion and the measurement of properties such as friction, wear-tear and abrasion. While designing nano-scale biomedical devices, the consideration of tribology is particularly important because the high surface area ratio enhances problems with friction and wear-tear which can further affects its function as well as longevity.

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Abbreviations

AD:

Alzheimer’s disease

Aβ:

Amyloid beta

CAT:

Catalase

CLP:

Regulation concerning Classification, Labeling and Packaging of Substances and Mixtures

EGF:

Epidermal growth factor

FGH:

fibroblast growth factor

LSPR:

Large Surface Area Plasmon resonance

Mn3O4:

Manganese oxide

PBCA-Ti/Au:

Polybutylcyanoacrylate polymer-Titanium/Aluminum

PDGF:

Platelet-derived growth factor

REACH:

Registration, Evaluation, Authorization and Restrictions of Chemicals

ROS:

Reactive oxygen species

SERs:

Surface-enhanced Raman Scattering

SNC:

Substantial Nigra pars Compacta

SNURs:

Significant New Use Rules

TSCA:

Toxic Substance Control Act

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, India

    Pravin Shende & Drashti Patel

Authors
  1. Pravin Shende
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  2. Drashti Patel
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Correspondence to Pravin Shende .

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Editors and Affiliations

  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Shende, P., Patel, D. (2019). Potential of Tribological Properties of Metal Nanomaterials in Biomedical Applications. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 7. Advances in Experimental Medicine and Biology(), vol 1237. Springer, Cham. https://doi.org/10.1007/5584_2019_440

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