Abstract
Skin as the outer layer covers the body. Wounds can affect this vital organ negatively and disrupt its functions. Wound healing as a biological process is initiated immediately after an injury. This process consists of three stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors such as infection, obesity and diabetes mellitus can interfere with these stages and impede the normal healing process which results in chronic wounds. Financial burden on both patients and health care systems, negative biologic effect on the patient’s general health status and reduction in quality of life are a number of issues which make chronic wounds as a considerable challenge. During recent years, along with advances in the biomedical sciences, various surgical and non-surgical therapeutic methods have been suggested. All of these suggested treatments have their own advantages and disadvantages. Recently, cell-based therapies and regenerative medicine represent promising approaches to wound healing. Accordingly, several types of mesenchymal stem cells have been used in both preclinical and clinical settings for the treatment of wounds. Adipose-derived stromal cells are a cost-effective source of mesenchymal stem cells in wound management which can be easily harvest from adipose tissues through the less invasive processes with high yield rates. In addition, their ability to secrete multiple cytokines and growth factors, and differentiation into skin cells make them an ideal cell type to use in wound treatment. This is a concise overview on the application of adipose-derived stromal cells in wound healing and their role in the treatment of chronic wounds.
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Abbreviations
- AMPs::
-
Antimicrobial peptides
- ASCs::
-
Adipose-derived stromal Cells
- bFGF::
-
Basic fibroblast growth factor
- BM-MSCs::
-
Bone marrow-derived mesenchymal stem cells
- DFU::
-
Diabetic foot ulcer
- ECM::
-
Extracellular Matrix
- EGF::
-
Epidermal growth factor
- FGF2::
-
Fibroblast growth factor-2
- GAGs::
-
Glycosaminoglycans
- HBOT::
-
Hyperbaric oxygen therapy
- HBSs::
-
Hypertrophic burn scars
- HGF::
-
Epidermal growth factor
- HTSs::
-
Hypertrophic scars
- IGF::
-
Insulin-like growth factor
- IL-1α::
-
Interleukin 1 alpha
- IL-6::
-
Interleukin 6
- KGF::
-
Keratinocyte growth factor
- MMPs::
-
Matrix metalloproteinases
- MSC::
-
Mesenchymal stromal cells
- NPWT::
-
Negative pressure wound therapy
- NRGs::
-
Neuregulins
- PDGF::
-
Platelet-derived growth factor
- PMNs::
-
Polymorphonuclear leukocytes
- PU::
-
Pressure ulcer
- SDF1::
-
Stromal-derived factor 1
- SSI::
-
Surgical site infection
- SVF::
-
Stromal vascular fraction
- TGF-β::
-
Transforming growth factor beta
- TIMPs::
-
Tissue inhibitor of metalloproteinases
- TNF-α::
-
Tumor necrosis factor
- VEGF::
-
Vascular endothelial growth factor
- VLU::
-
Venous leg ulcers
- VPF::
-
Vascular permeability factor
- CAL::
-
Cell-Assisted Lipotransfer
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The authors would like to acknowledge Dr. Mohsen khorshidi, Dr. Salman Radkarim, Rasta Arjmand, and Maryam Afshari for their kind support.
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Goodarzi, P. et al. (2018). Adipose Tissue-Derived Stromal Cells for Wound Healing. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 4. Advances in Experimental Medicine and Biology(), vol 1119. Springer, Cham. https://doi.org/10.1007/5584_2018_220
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