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Boron-Doped Diamond and Graphitic Multiarrays for Neurotransmitter Sensing

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Carbon-Based Nanosensor Technology

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 17))

Abstract

Synaptic transmission is based on quantal release of neurotransmitters. Alterations of the molecular mechanisms and components governing exocytosis are at the basis of several neurological and neurodegenerative diseases. The aim of this chapter is to provide an overview on the most recent advances of boron-doped diamond (BDD) and graphitic multiarrays in monitoring quantal release of oxidizable neurotransmitters with submillisecond time resolution.

In Sect. 1, diamond technology for realizing planar and flexible implantable arrays is detailed, as well as the electrochemical, Raman, and optical characterization of the materials. Section 2 is mainly dedicated to unravel the advantages of using high-density and low-density micro- and ultramicroarrays to perform multisite detection of quantal exocytosis, demonstrating their suitability to resolve subcellular exocytosis and to detect release from many cells simultaneously. The physiological relevance of the amperometric spike and its correspondence with the exocytotic event is described. Section 3 is focused on the great potentiality of emerging sensors based on quantum detection and their application in biosensing for imaging with atomic resolution.

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Authors and Affiliations

  1. Institute of Electron Devices and Circuits, Ulm University, Ulm, Germany

    Alberto Pasquarelli

  2. Physics Department, University of Turin, Turin, Italy

    Federico Picollo

  3. Nanostructured Interfaces and Surfaces Inter-departmental Centre, University of Turin, Turin, Italy

    Federico Picollo & Valentina Carabelli

  4. Istituto Nazionale di Fisica Nucleare (INFN) – Sezione di Torino, Turin, Italy

    Federico Picollo

  5. Department of Drug Science and Technology, University of Turin, Turin, Italy

    Valentina Carabelli

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  1. Alberto Pasquarelli
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  2. Federico Picollo
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  3. Valentina Carabelli
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Correspondence to Valentina Carabelli .

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Editors and Affiliations

  1. Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany

    Christine Kranz

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Pasquarelli, A., Picollo, F., Carabelli, V. (2018). Boron-Doped Diamond and Graphitic Multiarrays for Neurotransmitter Sensing. In: Kranz, C. (eds) Carbon-Based Nanosensor Technology. Springer Series on Chemical Sensors and Biosensors, vol 17. Springer, Cham. https://doi.org/10.1007/5346_2018_24

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