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Functions of Nuclear Polyphosphoinositides

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Lipid Signaling in Human Diseases

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 259))

Abstract

Despite interest in phosphoinositide (PtdIns) kinases, such as PtdIns 3 kinases (PI3K), as targets for controlling plasma membrane PtdIns levels in disease, the PtdIns have another less well-known site of action in the cell nucleus.

Recent studies show that PtdIns use a variety of strategies to alter DNA responses. Here, we provide an overview of these newly identified forms of gene expression control, which should be considered when studying the therapeutic use of PtdIns-directed compounds. As PI3K is one of the most important clinical targets in recent years, we will focus on two polyphosphoinositides, the PI3K substrate PtdIns(4,5)di-phosphate (PI4,5P2) and its product PtdIns(3,4,5)tri-phosphate (PI3,4,5P3).

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Authors and Affiliations

  1. Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain

    Manuel Olazabal-Morán, Ana González-García & Ana C. Carrera

Authors
  1. Manuel Olazabal-Morán
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  2. Ana González-García
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  3. Ana C. Carrera
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Correspondence to Ana C. Carrera .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH, USA

    Julian Gomez-Cambronero

  2. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA

    Michael A. Frohman

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Olazabal-Morán, M., González-García, A., Carrera, A.C. (2019). Functions of Nuclear Polyphosphoinositides. In: Gomez-Cambronero, J., Frohman, M. (eds) Lipid Signaling in Human Diseases. Handbook of Experimental Pharmacology, vol 259. Springer, Cham. https://doi.org/10.1007/164_2019_219

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