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Mechanisms of Resistance to Targeted Therapies in Chronic Myeloid Leukemia

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Book cover Mechanisms of Drug Resistance in Cancer Therapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 249))

Abstract

Patients with newly diagnosed chronic myeloid leukemia (CML) usually received as first-line treatment a first- or second-generation tyrosine kinase inhibitor (TKI). Although initial responses are high, therapy fails in up to 40% of patients and initial response is lost within 2 years in approximately 25% of patients. In the last few years, intensive efforts have been spent to explain treatment failure, and different mechanisms of resistance have been identified, ranging from BCR-ABL1 kinase domain mutations to lack of adherence to therapy. In this review, we briefly summarize the clinical efficacy of approved TKIs and describe the main mechanisms of TKI resistance.

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Authors and Affiliations

  1. Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII Bergamo, Bergamo, Italy

    Federico Lussana, Tamara Intermesoli, Paola Stefanoni & Alessandro Rambaldi

  2. Department of Oncology and Hematology, Università degli Studi di Milano, Milan, Italy

    Alessandro Rambaldi

Authors
  1. Federico Lussana
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  2. Tamara Intermesoli
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  3. Paola Stefanoni
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  4. Alessandro Rambaldi
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Corresponding author

Correspondence to Tamara Intermesoli .

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Editors and Affiliations

  1. Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy

    Mario Mandalà

  2. Department of Oncology, INSERM Res Unit 932, Institut Curie, Paris Cedex 05, France

    Emanuela Romano

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Lussana, F., Intermesoli, T., Stefanoni, P., Rambaldi, A. (2018). Mechanisms of Resistance to Targeted Therapies in Chronic Myeloid Leukemia. In: Mandalà, M., Romano, E. (eds) Mechanisms of Drug Resistance in Cancer Therapy. Handbook of Experimental Pharmacology, vol 249. Springer, Cham. https://doi.org/10.1007/164_2017_81

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