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Mechanisms of Drug Resistance in Cancer Therapy pp 109–128Cite as

Mechanisms of Resistance to Immune Checkpoint Antibodies

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 249))

Abstract

Immunotherapy using checkpoint inhibitors has changed the way we treat several aggressive cancers such as melanoma, non-small cell lung and head & neck cancers, among others, with durable responses achieved in the metastatic setting. However, unfortunately, the vast majority of patients do not respond to checkpoint inhibition therapy and a minority of patients, who do respond to treatment, develop secondary resistance and experience relapse by mechanisms still inadequately understood. Emerging evidence shows that alterations in multiple signaling pathways are involved in primary and/or secondary resistance to checkpoint inhibition. In this review we discuss how selected cancer-cell autonomous cues may influence the outcome of cancer immunotherapy, particularly immune checkpoint inhibition.

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Acknowledgment

EP work is funded by SiRIC Curie (Grant INCA-DGOS-4654).

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Authors and Affiliations

  1. Translational Immunotherapy Siric Team, Institut Curie, PSL Research University, INSERM U932, Paris, 75005, France

    Rodrigo N. Ramos & Eliane Piaggio

  2. Center of Cancer Immunotherapy, Institut Curie, PSL Research University, Paris, 75005, France

    Rodrigo N. Ramos, Eliane Piaggio & Emanuela Romano

  3. Centre d’Investigation Clinique Biothérapie CICBT 1428, Institut Curie, PSL Research University, Paris, 75005, France

    Eliane Piaggio & Emanuela Romano

  4. Department of Oncology, Institut Curie, PSL Research University, Office 2A-5, 26, Rue d’Ulm, Paris, 75005, France

    Emanuela Romano

Authors
  1. Rodrigo N. Ramos
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  2. Eliane Piaggio
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  3. Emanuela Romano
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Correspondence to Emanuela Romano .

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Editors and Affiliations

  1. Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy

    Mario Mandalà

  2. Department of Oncology, INSERM Res Unit 932, Institut Curie, Paris Cedex 05, France

    Emanuela Romano

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Ramos, R.N., Piaggio, E., Romano, E. (2017). Mechanisms of Resistance to Immune Checkpoint Antibodies. In: Mandalà, M., Romano, E. (eds) Mechanisms of Drug Resistance in Cancer Therapy. Handbook of Experimental Pharmacology, vol 249. Springer, Cham. https://doi.org/10.1007/164_2017_11

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