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Nanohybrid Scaffolds for the Treatment of Diabetic Wounds

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Pressure Injury, Diabetes and Negative Pressure Wound Therapy

Part of the book series: Recent Clinical Techniques, Results, and Research in Wounds ((RCTRRW,volume 3))

Abstract

Diabetic wounds are the main cause of mortality in patients with diabetes. Recent reports suggest that even though the pathophysiology of diabetic wound is multifactorial, persistent inflammation with infections and lack of tissue regeneration (tissue management) leads to impaired wound healing in diabetes and leaves these wounds in a chronic nonhealing stage. Hence, the aim of this investigation is to formulate drug (curcumin and doxycycline hyclate)-loaded biomimetic collagen–alginate composite nanohybrid scaffolds which have both anti-inflammatory and antibacterial activities for potential tissue regeneration in diabetic wounds. The prepared novel composite nanohybrid scaffolds satisfied the properties of an ideal diabetic wound dressing in terms of mechanical strength, swelling, porosity, biodegradation, biocompatibility, controlled release, cell adhesion, and proliferation with antibacterial anti-inflammatory properties which are crucial for tissue regeneration in diabetic wounds. Hence, this study suggests that the synergistic combination of curcumin, doxycycline hyclate (anti-inflammatory and antibacterial), chitosan (controlled drug carrier, wound healing), collagen (established wound healer), and alginate (biomaterial for regenerative medicine) is a promising strategy to address various pathological manifestations of diabetic wounds and has better wound healing capability.

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Authors and Affiliations

  1. Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, India

    Veera Venkata Satyanarayana Reddy Karri & Gowthamarajan Kuppusamy

  2. Jagadguru Sri Shivarathreeshwara University, Mysuru, India

    Veera Venkata Satyanarayana Reddy Karri, Gowthamarajan Kuppusamy & Ashish Devidas Wadhwani

  3. Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, Ootacamund, India

    Ashish Devidas Wadhwani

  4. Pharmacokinetic Research and Development, Sun Pharmaceutical Industries Ltd., Part Survey No. 27 C.S No. 1050, Village Tandalja, Baroda, India

    Rajkumar Malayandi

Authors
  1. Veera Venkata Satyanarayana Reddy Karri
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  2. Gowthamarajan Kuppusamy
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  3. Ashish Devidas Wadhwani
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  4. Rajkumar Malayandi
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Correspondence to Veera Venkata Satyanarayana Reddy Karri .

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Editors and Affiliations

  1. Tustin, CA, USA

    Melvin A. Shiffman

  2. Newport Beach, CA, USA

    Mervin Low

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Karri, V.V.S.R., Kuppusamy, G., Wadhwani, A.D., Malayandi, R. (2017). Nanohybrid Scaffolds for the Treatment of Diabetic Wounds. In: Shiffman, M., Low, M. (eds) Pressure Injury, Diabetes and Negative Pressure Wound Therapy. Recent Clinical Techniques, Results, and Research in Wounds, vol 3. Springer, Cham. https://doi.org/10.1007/15695_2017_46

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  • DOI: https://doi.org/10.1007/15695_2017_46

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-10700-0

  • Online ISBN: 978-3-030-10701-7

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