Summary
Various diverse research findings have been summarized to develop the boron-inflammation regulation hypothesis that boron reduces the risk for inflammatory disease by serving as a suppressive signal that down-regulates enzymatic activities typically elevated during the normal inflammatory process. There is in vivo evidence for an immunomodulatory effect of physiologic amounts of dietary boron. Specifically, boron helps control the normal inflammatory process by modulating the response of key immune cells to antigens by an undefined mechanism. Boron may act to regulate the normal inflammatory process by serving as a signal suppressor that down-regulates the activities of specific enzymes involved in the inflammatory process and thus may play a role in modulating the development of inflammatory disease. Suppression, but not elimination, of activities of these enzymes is hypothesized to reduce the incidence and severity of the symptoms of inflammatory disease.
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References
Bachovchin, W.W., Wong, W.Y.L., Farr-Jones, S., Shenvi, A.B., and Kettner, C.A., 1988, Nitrogen-15 NMR spectroscopy of the catalytic-triad histidine of a serine protease in peptide boronic acid inhibitor complexes, Biochem.27:7689–7697.
Bai, Y. and Hunt, C.D., 1995, Dietary boron alleviates adjuvant-induced arthritis (AIA) in rats, FASEB J.9:A576.
Bai, Y., Hunt, C.D., and Newman Jr, S.M., 1997, Dietary boron increases serum antibody (IgG and IgM) concentrations in rats immunized with human typhoid vaccine, Proc. N. D. Acad. Sci.51:181.
Belver, A. and Donaire, J.P., 1983, Partial purification of soluble lipoxygenase of sunflower cotyledons: action of boron on the enzyme and lipid constituents, Z. Pflanzenphysiol Bd.109:309–317.
Berezin, I.V., Vill, K.H., Martinek, K., and Yatsimirshii, A.K., 1967, Reversible inactivation of alpha-chymotrypsin resulting from interaction of Cu++ ions with the imidazole group of a histidine residue, Molek. Biol.1:719–728.
Berry, S.C., Fink, A.L., Shenvi, A.B., and Kettner, C.A., 1988, Interaction of peptide boronic acids with elastase: circular dichroism studies, Proteins: Structure, Function, and Genetics4:205–210.
Fracp, R.L.T., Rennie, G.C., and Newnham, R.E., 1990, Boron and arthritis: the results of a double-blind pilot study, J. Nutr. Med.1:127–132.
Fritz, H., Jochum, M., Geiger, R., Duswald, H.H., Dittmer, H., Kortmann, H., Neumann, S., and Lang, H., 1986, Granulocyte proteinases as mediators of unspecific proteolysis in inflammation: a review, Folia Histochem. Cytobiol.24:99–115.
Gallin, J.I., Goldstein, I.M., and Snyderman, R., 1988, Inflammation: Basic Principles and Clinical Correlates, Ed., Raven Press, New York.
Harris Jr, E.D., 1988, Pathogenesis of rheumatoid arthritis: a disorder associated with dysfunctional immunoregulation, in: Inflammation: Basic Principles and Clinical Correlates, (J.I. Gallin, I.M. Goldstein, and R. Snyderman, eds.), pp. 751–773, Raven Press, New York.
Hausdorf, G., Krüger, K., Küttner, G., Holzhütter, H.-G., Frömmel, C., and Höhne, W.E., 1987, Oxidation of a methionine residue in subtilisin-type proteinases by the hydrogen peroxide/borate system-an active site-directed reaction, Biochim. Biophys. Acta952:20–26.
Hellstrand, K., Asea, A., Dahlgren, C., and Hermodsson, S., 1994, Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites, J. Immunol.153:4940–4947.
Hunt, C.D., Halas, E.S., and Eberhardt, M.J., 1988, Long-term effects of lactational zinc deficiency on bone mineral composition in rats fed a commercially modified Luecke diet, Biol. Trace Elem. Res.16:97–113.
Hunt, C.D. and Idso, J.P., In press, Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress, J. Trace Elem. Exp. Med.
Kavanaugh, A.F. and Kipsky, P.E., 1995, Rheumatoid arthritis, in: Inflammation: Basic Principles and Clinical Correlates, (R.R. Rich, T.A. Fleisher, B.D. Schwartz, W.T. Shearer, and W. Strober, eds.), pp. 1093–1116, Mosby, St. Louis.
Kettner, C., Mersinger, L., and Knabb, R., 1990, The selective inhibition of thrombin by peptides of boroarginine, J. Biol. Chem.265:18289–18297.
Klebanoff, S.J., 1988, Phagocytic cells: products of oxygen metabolism, in: Inflammation: Basic Principles and Clinical Correlates, (J.K. Gallin, I.M. Goldstein, and R. Snyderman, eds.), pp. 391–444, Raven Press, New York.
Lovatt, C.J. and Dugger, W.M., 1984, Boron, in: Biochemistry of the Essential Ultratrace Elements, (E. Frieden, eds.), pp. 389–421, Plenum Press, New York.
Niehaus, G.D., Kimura, R., Traber, L.D., Herndon, D.N., Flynn, J.T., and Traber, D.L., 1990, Administration of a synthetic antiprotease reduces smoke-induced lung injury, J. Appl. Physiol.69:694–699.
Nielsen, F.H., 1989, Dietary boron affects variables associated with copper metabolism in humans, in: 6th International Trace Element Symposium 1989, (M. Anke, W. Baumann, H. Braünlich, C. Brückner, B. Groppel, and M. Grün, eds.), pp. 1106–1111, Karl-Marx-Universitat, Leipzig and Friedrich-Schiller-Universitat, Jena, DDR.
Rajendran, K.G., Burnham, B.S., Sood, C.A., Spielvogel, B.F., Shaw, B.R., and Hall, I.H., 1994, Antiinflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents, J. Pharm. Sci.83:1391–1395.
Shah, S.A. and Vohora, S.B., 1990, Boron enhances anti-arthritic effects of garlic oil, Fitoterapia61:121–126.
Snyder, D.W., Aharony, D., Dobson, P., Tsai, B.S., and Krell, R.D., 1984, Pharmacological and biochemical evidence for metabolism of peptide leukotrienes by guinea-pig airway smooth muscle in vitro, J. Pharmacol. Exp. Ther.231:224–229.
Spielberg, S.P., Butler, J.D., MacDermot, K., and Schulman, J.D., 1979, Treatment of glutathione synthetase deficient fibroblasts by inhibiting gamma-glutamyl transpeptidase activity with serine and borate, Biochem. Biophys. Res. Commun.89:504–511.
Tate, S.S. and Meister, A., 1978, Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase, Proc. Natl. Acad. Sci. USA75:4806–4809.
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Hunt, C.D. (2002). Dietary Boron is a Physiological Regulator of the Normal Inflammatory Response. In: Roussel, A.M., Anderson, R.A., Favier, A.E. (eds) Trace Elements in Man and Animals 10. Springer, New York, NY. https://doi.org/10.1007/0-306-47466-2_327
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DOI: https://doi.org/10.1007/0-306-47466-2_327
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