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Metallothioneins

Their Cellular Function and Relationship with Zinc

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Trace Elements in Man and Animals 10

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References

  • Abdel-Mageed, A. and Agrawal, K.C., 1997, Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells. Cancer Gene Ther., 4:199–207.

    CAS  PubMed  Google Scholar 

  • Abdel-Mageed, A.B. and Agrawal, K.C., 1998, Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response. Cancer Res., 58:2335–2338.

    CAS  PubMed  Google Scholar 

  • Beattie, J.H., Black, D.J., Duncan, J.S., Wood, A.M., and Trayhurn, P., 1996, Cold-induced expression of the metallothionein-1 gene in brown adipose tissue of rats. Am. J. Physiol, 270:R971–R977.

    CAS  PubMed  Google Scholar 

  • Beattie, J.H., Wood, A.M., and Duncan, J.S., 1999, Rat metallothionein-2 contains N α-acetylated and unacetylated isoforms. Electrophoresis, (In Press).

    Google Scholar 

  • Beattie, J.H., Wood, A.M., Newman, A.M., Bremner, I., Choo, K.H.A., Michalska, A.E., Duncan, J.S., and Trayhurn, P., 1998, Obesity and hyperleptinemia in metallothionein (-I and-II) null mice. Proc. Natl. Acad. Sci. U.S.A., 95:358–363.

    Article  CAS  Google Scholar 

  • Bittel, D. and Andrews, G.K., 1998a, The Zn-fingers of MTF-1 contain a mechanism for sensing intracellular free Zn (Abstract). International Conference on Metal-binding Proteins in Biology, Banff, Alberta, Canada, p. 46.

    Google Scholar 

  • Bittel, D., Dalton, T., Samson, S.A., Gedamu, L., and Andrews, G.K., 1998b, The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem., 273:7127–7133.

    Article  CAS  Google Scholar 

  • Chu, W.A., Moehlenkamp, J.D., Bittel, D., Andrews, G.K., and Johnson, J.A., 1999, Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1. J. Biol. Chem., 274:5279–5284.

    Article  CAS  Google Scholar 

  • Erickson, J.C., Hollopeter, G., Thomas, S.A., Froelick, G.J., and Palmiter, R.D., 1997, Disruption of the metailothionem-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci., 17:1271–1281.

    Article  CAS  Google Scholar 

  • Gasull, T. and Hidalgo, J., 1996, Evidence for a high molecular weight cytosolic factor that binds brain and liver metallothionein. Neurochem. Res., 21:969–974.

    Article  CAS  Google Scholar 

  • Gunes, C., Heuchel, R., Georgiev, O., Muller, K.H., Lichtlen, P., Bluthmann, H., Marino, S., Aguzzi, A., and Schaffner, W, 1998, Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J., 17:2846–2854.

    Article  CAS  Google Scholar 

  • Jasani, B. and Schmid, K.W., 1997, Significance of metallothionein overexpression in human tumours [In Process Citation]. Histopathology, 31:211–214.

    Article  CAS  Google Scholar 

  • Jiang, L.J., Maret, W., and Vallee, B.L., 1998, The glutathioneredox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase [In Process Citation], Proc. Natl. Acad. Sci. U.S.A., 95:3483–3488.

    Article  CAS  Google Scholar 

  • Kelly, E.J., Sandgren, E.P., Brinster, B.L., and Palmiter, R.D., 1997, A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes. Proc. Natl. Acad. Sci. U.S.A., 94:10045–10050.

    Article  CAS  Google Scholar 

  • Klaassen, C.D. and Liu, J., 1998, Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity [In Process Citation]. J. Toxicol. Sci., 23 Suppl 2:97–102:97–102.

    Article  CAS  Google Scholar 

  • Koizumi, S., Suzuki, K., Ogra, Y, Yamada, H., and Otsuka, F., 1999, Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene. Eur. J. Biochem., 259:635–642.

    Article  CAS  Google Scholar 

  • Kondo, Y., Rusnak, J.M., Hoyt, D.G., Settineri, C.E., Pitt, B.R., and Lazo, J.S., 1997, Enhanced apoptosis in metallothionein null cells. Mol. Pharmacol, 52:195–201.

    Article  CAS  Google Scholar 

  • Lazo, J.S., Kondo, Y., Dellapiazza, D., Michalska, A.E., Choo, K.H.A., and Pitt, B.R., 1995, Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem., 270:5506–5510.

    Article  CAS  Google Scholar 

  • Lee, D.K., Carrasco, J., Hidalgo, J., and Andrews, G.K., 1999, Identification of a signal transducer and activator of transcription, (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochem. J, 337:59–65.

    Article  CAS  Google Scholar 

  • Liu, J., Liu, Y., Michalska, A.E., Choo, K.H.A., and Klaassen, C.D., 1996a, Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol, 136:260–268.

    Article  CAS  Google Scholar 

  • Liu, J., Liu, Y.P., Michalska, A.E., Choo, K.H.A., and Klaassen, CD., 1996b, Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol, 136:260–268.

    Article  CAS  Google Scholar 

  • Mahon, P., Partridge, K., Beattie, J.H., Glover, L.A., and Hesketh, J.E., 1997, The 3′ untranslated region plays a role in the targeting of metallothionein-I mRNA to the perinuclear cytoplasm and cytoskeletal-bound polysomes. Biochim. Biophys. Acta, 1358:153–162.

    Article  CAS  Google Scholar 

  • Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L., and Palmiter, R.D., 1994, Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. U.S.A., 91:584–588.

    Article  CAS  Google Scholar 

  • Michalska, A.E. and Choo, K.H.A., 1993, Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A., 90:8088–8092.

    Article  CAS  Google Scholar 

  • Moffatt, P. and Seguin, C., 1998, Expression of the gene encoding metallothionein-3 in organs of the reproductive system [In Process Citation]. DNA Cell Biol., 17:501–510.

    Article  CAS  Google Scholar 

  • Murphy, B.J., Andrews, G.K., Bittel, D., Discher, D.J., McCue, J., Green, C.J., Yanovsky, M., Giaccia, A., Sutherland, R.M., Laderoute, K.R., and Webster, K.A., 1999, Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res., 59:1315–1322.

    CAS  PubMed  Google Scholar 

  • Pitt, B.R., Schwarz, M., Woo, E.S., Yee, E., Wasserloos, K., Tran, S., Weng, W., Mannix, R.J., Watkins, S.A., Tyurina, Y.Y., Tyurin, V.A., Kagan, V.E., and Lazo, J.S., 1997, Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am. J. Physiol, 273:L856–L865.

    CAS  PubMed  Google Scholar 

  • Quaife, C.J., Kelly, E.J., Masters, B.A., Brinster, R.L., and Palmiter, R.D., 1998, Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice [Full text delivery]. Toxicol. Appl. Pharmacol., 148:148–157.

    Article  CAS  Google Scholar 

  • Samson, S.L. and Gedamu, L., 1998, Molecular analyses of metallothionein gene regulation. Prog. Nucleic Acid Res. Mol. Biol., 59:257–288.

    Article  CAS  Google Scholar 

  • Sato, M., Apostolova, M.D., Hamaya, M., Yamaki, J., Choo, K.H.A., Michalska, A.E., Kodama, N., and Tohyama, C., 1996, Susceptibility of metallothionein-null mice to paraquat. Environ. Toxicol. Pharmacol., 1:221–225.

    Article  CAS  Google Scholar 

  • Sewell, A.K., Jensen, L.T., Erickson, J.C., Palmiter, R.D., and Winge, D.R., 1995, Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties. Biochemistry, 34:4740–4747.

    Article  CAS  Google Scholar 

  • Studer, R., Vogt, C.P., Cavigelli, M., Hunziker, P.E., and Kagi, J.H., 1997, Metallothionein accretion in human hepatic cells is linked to cellular proliferation. Biochem. J., 328:63–67.

    Article  CAS  Google Scholar 

  • Thornalley, P.J. and Vasak, M., 1985, Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta, 827:36–44.

    Article  CAS  Google Scholar 

  • Tohyama, C., Suzuki, J.S., Hemelraad, J., Nishimura, N., and Nishimura, H., 1993, Induction of metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy. Hepatology, 18:1193–1201.

    Article  CAS  Google Scholar 

  • Tsujikawa, K., Imai, T., Kakutani, M., Kayamori, Y., Mimura, T., Otaki, N., Kimura, M., Fukuyama, R., and Shimizu, N., 1991, Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes. FEBS Lett., 283:239–242.

    Article  CAS  Google Scholar 

  • Uchida, Y. and Ihara, Y., 1995, The N-terminal portion of growth inhibitory factor is sufficient for biological activity. J. Biol.Chem., 270:3365–3369.

    Article  CAS  Google Scholar 

  • Vasconcelos, H., Tam, S.C., Beattie, J.H., and Hesketh, J., 1995, Evidence for differences in the posttranscriptional regulation of rat metallothionein isoforms. Biochem. J., 314:665–671.

    Google Scholar 

  • Whitacre, C.M., 1996, Application of Western blotting to the identification of metallothionein binding proteins. Anal. Biochem., 234:99–102.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Trace Element and Gene Expression Group, Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, UK

    John H. Beattie & Ian Bremner

Authors
  1. John H. Beattie
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  2. Ian Bremner
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Editors and Affiliations

  1. Joseph Fourier University, Grenoble, France

    A. M. Roussel  & A. E. Favier  & 

  2. Beltsville Human Nutrition Research Center, Beltsville, Maryland, USA

    R. A. Anderson

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© 2002 Kluwer Academic Publishers

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Beattie, J.H., Bremner, I. (2002). Metallothioneins. In: Roussel, A.M., Anderson, R.A., Favier, A.E. (eds) Trace Elements in Man and Animals 10. Springer, New York, NY. https://doi.org/10.1007/0-306-47466-2_301

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  • DOI: https://doi.org/10.1007/0-306-47466-2_301

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