Conclusions
Our results have shown that nonheme iron status of rats is strongly affected already at the early stage of glial brain tumour growth. The ferritin iron indices increase essentially in the blood, liver, in the brain tumour and in the cortex symmetric to the tumour, i.e. the brain as a whole is enriched in ferritin iron in rats bearing glial brain tumour. A further work implies the estimation of the nonheme iron exchange parameters determined in the blood and brain tissues taken from patients bearing glial brain tumours and evaluation of their diagnostic power as well as testing of iron chelators as antiproliferative agents in the case of glial brain tumours.
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References
Connor, J.R., 1993, Cellular and Regional maintenance of iron homeostasis in the brain: normal and diseased states, in: Iron in central nervous system disorders (P. Riederer and M.B.H. Youdim, eds.), pp. 1–18, Springer-Verlag, New York.
Estrov, Z., Tawa, A., Wang, X.H., Dube, I.D., Sulh, H., Cohen, A., Gelfand, E.W., and Freedman, M.H., 1987, In vitro and in vivo effects of deferoxamine in neonatal acute leukemia, Blood69:757–761.
Huges, N.R., 1972, Serum transferrin and ceruloplasmin concentrations in patients with carcinoma, melanoma, sarcoma and cancers of haematopoietic tissues, Aust. J. Exp. Biol. Med. Sci.50:97–107.
Mykhaylyk, O.M., Razumov, O.N., Dudchenko, A.K., Pankratov, Yu. V., Dobrinsky, Ed. K., Sosnitsky, V.N., and Bakai, Ed. A., 1997, Use of ESR, Mossbauer spectroscopy and SQUID-magnetometry for the characterization of magnetic nanoparticles on the base of metal iron and its implications in vivo, in: Scientific and Clinical Applications of Magnetic Carriers (U. Hafeli, W. Schutt, J. Teller, and M. Zborowski, eds.), pp. 177–204, Plenum Press, New York.
Mykhaylyk, O.M. and Dudchenko, N.A., 1998, Nonheme iron determination in biological samples on evidence derived from electron spin resonance data, in: Metal Ions in Biology and Medicine, Volume 5 (P. Collery, P. Bratter, V.N. de Bratter, L. Khassanova, and J.-C. Etienne, eds.), pp. 3–7, John Libbey Eurotext, Paris.
Recht, L., Torres, C.O., Smith, T.W., Raso, V, and Griffin, T.W., 1990, Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy, J. Neurosurg.72:941–945.
Richardson, D.R. and Milnes, K., 1997, The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone, Blood89:3025–3038.
Stevens, R.G., Jones, D.Y., Micozzi, M.S., and Taylor, PR., 1988, Body iron stores and the risk of cancer, New Eng. J. Med.319:1047–1051.
Vymazal, J.A., Brooks, R.A., Baumgarner, C.A., Tran, V.A., Katz, D.A., Bulte, J.W.A., Bauminger, R.A., and Di Chiro, G.T., 1996, The relation between brain iron and NMR relaxation times: an in vitro study, J. Magn. Reson. Med.35:56–61.
Weinberg, E.D., 1984, Iron withholding: a defence against infection and neoplasia, Physiol. Rev.64:65–102.
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Mykhaylyk, O.M., Dudchenko, N.A., Lebedev, E.A., Shurunov, B.S., Cherchenko, A.P., Zozulya, Y.A. (2002). Peculiarities of Nonheme Iron Metabolism Upon Experimental Modelling of Rat Glial Brain Tumour. Perspectives for Diagnosis and Treatment. In: Roussel, A.M., Anderson, R.A., Favier, A.E. (eds) Trace Elements in Man and Animals 10. Springer, New York, NY. https://doi.org/10.1007/0-306-47466-2_259
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